Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human ARFGAP1 protein, GST-tagged

Cat.No. : ARFGAP1-750H
Product Overview : Human ARFGAP1 full-length ORF ( AAH28233, 1 a.a. - 414 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 71.28 kDa
AA Sequence : MASPRTRKVLKEVRVQDENNVCFEC GAFNPQWVSVTYGIWICLECSGRHR GLGVHLSFVRSVTMDKWKDIELEKM KAGGNAKFREFLESQEDYDPCWSLQ EKYNSRAAALFRDKVVALAEGREWS LESSPAQNWTPPQPRTLPSMVHRVS GQPQSVTASSDKAFEDWLNDDLGSY QGAQGNRYVGFGNTPPPQKKEDDFL NNAMSSLYSGWSSFTTGASRFASAA KEGATKFGSQASQKFWGHKQQPEPA SELGHSLNENVLKPAQEKVKEGKIF DDVSSGVSQLASKGVGSKGWRDVTT FFSGKAEGPLDSPSEGHSYQNSGLD HFQNSNIDQSFWETFGSAEPTKTRK SPSSDSWTCADTSTERRSSDSWEVW GSASTNRNSNSDGGEGGEGTKKAVP PAVPTDDGWDNQNW
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 [ Homo sapiens ]
Official Symbol : ARFGAP1
Synonyms : ARFGAP1; ADP-ribosylation factor GTPase activating protein 1; ADP ribosylation factor 1 GTPase activating protein , ARF1GAP; ADP-ribosylation factor GTPase-activating protein 1; bA261N11.3; FLJ10767; ARF1 GAP; ARF GAP 1; GAP protein; ARF1-directed GTPase-activating protein; ADP-ribosylation factor 1 GTPase activating protein; ADP-ribosylation factor 1 GTPase-activating protein; ARF1GAP; HRIHFB2281; MGC39924;
Gene ID : 55738
mRNA Refseq : NM_018209
Protein Refseq : NP_060679
MIM : 608377
UniProt ID : Q8N6T3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (15)

Ask a question
What are the physiological roles of ARFGAP1? 11/07/2022

ARFGAP1 plays a critical role in membrane trafficking pathways within cells. It regulates the formation and budding of transport vesicles from the Golgi apparatus, involved in the retrograde transport of molecules between the Golgi and endosomes, and in the recycling of membrane proteins. ARFGAP1 also contributes to the maintenance of Golgi morphology and function.

How does ARFGAP1 contribute to cancer progression? 03/13/2022

Dysregulation of ARFGAP1 has been associated with cancer progression. It can affect the trafficking of molecules involved in cell growth, proliferation, and invasion, leading to the promotion of tumor development and metastasis. Additionally, ARFGAP1 may interact with other proteins involved in cell cycle control and cell signaling pathways implicated in cancer.

Can ARFGAP1 act as a tumor suppressor or an oncogene? 10/27/2021

The role of ARFGAP1 as a tumor suppressor or an oncogene is context-dependent and can vary depending on the type of cancer. In some cancers, ARFGAP1 expression is downregulated or lost, suggesting a potential tumor suppressor role. On the other hand, in certain cancer types, increased ARFGAP1 expression has been associated with cancer progression and poor prognosis, indicating an oncogenic role. Further studies are needed to fully elucidate the underlying mechanisms and determine the precise role of ARFGAP1 in different cancer contexts.

Can ARFGAP1 interact with other signaling pathways? 02/15/2021

Yes, ARFGAP1 has been shown to interact with other signaling pathways. For example, it has been implicated in the regulation of the Wnt signaling pathway by modulating the stability of Dvl2 protein, a key component of the pathway. ARFGAP1 may also interact with other cellular signaling pathways, although further research is necessary to fully understand these interactions.

Can ARFGAP1 be a potential therapeutic target? 02/11/2021

ARFGAP1 has shown promise as a potential therapeutic target, especially in diseases associated with abnormal vesicular trafficking, such as certain types of cancer. By modulating ARFGAP1 activity or targeting its interacting proteins, it may be possible to disrupt pathological cellular processes and inhibit disease progression. However, more research is necessary to better understand the precise mechanisms of ARFGAP1 involvement in various diseases and to develop effective and specific therapeutic strategies.

Are there any known genetic mutations or diseases linked to ARFGAP1? 09/04/2020

Yes, mutations in the ARFGAP1 gene have been linked to certain forms of central centrifugal cicatricial alopecia and some cases of hereditary spastic paraplegia, which are neurological disorders affecting movement and sensation.

What are the interacting partners of ARFGAP1? 07/09/2020

ARFGAP1 interacts with various components of the COPI (coat protein complex I) and COPII (coat protein complex II) vesicular trafficking complexes, as well as with other proteins involved in intracellular transport, such as clathrin and Rab GTPases.

Are there any drugs that target ARFGAP1? 06/22/2020

Currently, there are no approved drugs specifically targeting ARFGAP1. However, research is ongoing to develop small molecule inhibitors or other compounds that can modulate its activity as a potential therapeutic strategy.

How is the expression of ARFGAP1 regulated? 06/17/2020

The expression of ARFGAP1 can be regulated at the transcriptional level through the binding of various transcription factors to its promoter region. Additionally, post-transcriptional regulation and protein degradation pathways can influence its abundance within the cell.

Can ARFGAP1 be found in other organisms besides humans? 04/27/2020

Yes, ARFGAP1 is a highly conserved protein and can be found in various organisms across different species, including mammals, birds, reptiles, amphibians, and even invertebrates like fruit flies and worms.

How was the ARFGAP1 protein discovered? 11/19/2019

The ARFGAP1 protein was discovered through biochemical and molecular biology techniques. Researchers were investigating the mechanisms of intracellular vesicular trafficking and identified ARFGAP1 as a protein that regulates the activity of ADP-ribosylation factors (ARFs).

What are the implications of ARFGAP1 dysfunction? 12/28/2018

Dysregulation of ARFGAP1 can have various consequences on intracellular vesicular trafficking processes. It can affect the formation and dynamics of coated vesicles, impair Golgi apparatus function, and disrupt endosome-to-Golgi retrograde transport. ARFGAP1 dysregulation has been associated with diseases such as cancer and neurodegenerative disorders.

Can ARFGAP1 be a potential therapeutic target? 03/19/2018

ARFGAP1 has emerged as a potential therapeutic target for certain diseases, particularly cancer and neurodegenerative disorders. Modulating its activity could help regulate intracellular vesicular trafficking and potentially alleviate associated pathological conditions. However, further research is needed to explore the therapeutic potential and develop specific inhibitors or activators.

Are there any known inhibitors of ARFGAP1 activity? 08/14/2016

Currently, there are no specific inhibitors of ARFGAP1 activity available for clinical use. However, there have been efforts to develop small molecules or peptides that can selectively inhibit ARFGAP1 function as a potential strategy for therapeutic intervention. These inhibitors aim to disrupt the interaction between ARFGAP1 and its target proteins involved in vesicular trafficking, thereby modulating cellular processes influenced by ARFGAP1 activity.

Are there any mutations in the ARFGAP1 gene associated with human diseases? 07/10/2016

Yes, mutations in the ARFGAP1 gene have been identified in certain human diseases. For example, mutations in ARFGAP1 have been reported in individuals with autosomal recessive perisylvian polymicrogyria, a rare brain malformation disorder characterized by abnormal folding and development of the cerebral cortex. These mutations result in functional changes or loss of ARFGAP1 protein, leading to abnormal neuronal migration during brain development.

Customer Reviews (8)

Write a review
Reviews
08/06/2021

    Coupled with the exceptional technical support provided by the manufacturer, my experience with the ARFGAP1 Protein has been truly outstanding.

    01/24/2020

      They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the ARFGAP1 protein.

      10/06/2019

        The team has been exceptionally knowledgeable and responsive, promptly addressing any inquiries or issues that have arisen during my work.

        06/06/2019

          I highly recommend it to fellow researchers looking for a high-quality protein and excellent technical assistance.

          01/15/2019

            This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.

            06/05/2018

              Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the ARFGAP1 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.

              06/13/2017

                the technical support provided by the manufacturer is extraordinary.

                10/02/2016

                  The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.

                  Ask a Question for All ARFGAP1 Products

                  Required fields are marked with *

                  My Review for All ARFGAP1 Products

                  Required fields are marked with *

                  0

                  Inquiry Basket

                  cartIcon
                  logo

                  FOLLOW US

                  Terms and Conditions        Privacy Policy

                  Copyright © 2024 Creative BioMart. All Rights Reserved.

                  Contact Us

                  • /

                  Stay Updated on the Latest Bioscience Trends