ARFGEF2 Protein, ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

ARFGEF2

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ARFGEF2

Official Full Name ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Background ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.
Synonyms ARFGEF2; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); brefeldin A-inhibited guanine nucleotide-exchange protein 2; BIG2; Brefeldin A inhibited guanine nucleotide exchange protein 2; brefeldin A-inhibited GEP 2; PVN
    • Species :
    • Mouse
    • Rat
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse ARFGEF2-1847M Recombinant Mouse ARFGEF2 Protein Mammalian Cell His
    Rat ARFGEF2-756R Recombinant Rat ARFGEF2 Protein Mammalian Cell His

    ARFGEF2 involved in several pathways and played different roles in them. We selected most pathways ARFGEF2 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARFGEF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis CHMP2B; RHOAA; IL2RGB; ARFGAP2; ADRB1; TGFBR2; TSG101A; DNM3; PIP5K1BB; PIP5KL1

    ARFGEF2 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity, GABA receptor binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARFGEF2 itself. We selected most functions ARFGEF2 had, and list some proteins which have the same functions with ARFGEF2. You can find most of the proteins on our site.

    Function Related Protein
    ARF guanyl-nucleotide exchange factor activity GBF1; CYTH1; PSD3; FBXO8; CYTH4; CYTH4B; PSD2; CYTH1A; ARFGEF2; IQSEC1
    GABA receptor binding GABARAPL2; GABARAP; ARFGEF2; PLCL2; GABRB1; GABRA5; PLCL1; PPP2CA; GABARAPL1; MAF1
    guanyl-nucleotide exchange factor activity RANGRF; DOCK8; FLCN; TBC1D10A; ARHGEF7; SPATA13; ARHGEF11; DOCK7; RAPGEF3; RIC8
    myosin binding VEZT; KIRREL; NPHS1; CALM; SMYD1B; DMD; CALD1; MYBPC3; VETZ; ARFGEF2
    protein kinase A regulatory subunit binding ARFGEF1; AKAP6; AKAP1; AKAP5; KCNQ1; RYR2; PRKACA; AKAP9; C2orf88; AKAP7

    ARFGEF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARFGEF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARFGEF2.

    Iqcb1

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