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Recombinant Mouse ARFGEF2 Protein

Cat.No. : ARFGEF2-1847M
Product Overview : Recombinant Mouse ARFGEF2 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (19)

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Can ARFGEF2 be studied using animal models? 04/26/2023

Yes, ARFGEF2 can be studied using animal models such as mice. Gene knockout or knockdown approaches can be employed to investigate the consequences of ARFGEF2 loss-of-function in vivo. By analyzing these animal models, researchers can gain insight into the roles of ARFGEF2 in development, behavior, and disease.

What are the regulatory mechanisms that control the activity of ARFGEF2? 04/13/2023

The activity of ARFGEF2 can be regulated by several mechanisms. One of the main modes of regulation is through post-translational modifications such as phosphorylation and ubiquitination. Phosphorylation of specific residues within ARFGEF2 can either enhance or inhibit its activity, depending on the context. Ubiquitination can also impact ARFGEF2 activity by regulating its stability or subcellular localization.

Are there any animal models available for studying ARFGEF2 protein? 11/22/2022

Yes, animal models such as knockout mice have been generated to study the role of ARFGEF2 in vivo. These models provide valuable insights into the physiological functions of ARFGEF2 and its implications in diseases.

Are there any specific drugs that target ARFGEF2 activity? 07/15/2021

Currently, there are no specific drugs available that directly target ARFGEF2 activity. However, there may be potential for the development of small molecules or inhibitors that can modulate ARFGEF2 function or interaction with its binding partners. Further research is needed to explore this possibility.

What are the potential roles of ARFGEF2 in neuronal development and function? 04/09/2021

ARFGEF2 has been demonstrated to play important roles in neuronal development and function. It is involved in the regulation of neuronal migration, axon outgrowth, dendritic spine formation, and synaptic vesicle trafficking. Mice lacking ARFGEF2 exhibit defects in neuronal morphology and synaptic function, highlighting its significance in neurodevelopmental processes.

Is ARFGEF2 protein expressed in all cell types? 06/11/2020

ARFGEF2 is widely expressed in various cell types and tissues. However, its expression levels may vary between different cell types depending on their specific functions and requirements for vesicle trafficking and membrane dynamics.

Are there any known small molecules or drugs that specifically target ARFGEF2? 04/03/2020

Currently, no specific small molecules or drugs targeting ARFGEF2 have been reported. However, ongoing research on ARFGEF2 function and regulation may identify potential therapeutic strategies in the future.

Can ARFGEF2 protein interact with other proteins or signaling pathways? 09/19/2019

Yes, ARFGEF2 can interact with a variety of proteins and signaling pathways. It can interact with small GTPases such as ARF and Rho family members to regulate vesicle trafficking and cytoskeletal dynamics. ARFGEF2 can also interact with other proteins involved in membrane fusion, such as SNARE proteins. Additionally, it has been found to interact with signaling molecules such as protein kinases and phosphatases, suggesting its involvement in signal transduction pathways.

What are the potential therapeutic implications of studying ARFGEF2 protein? 08/09/2019

Understanding the role of ARFGEF2 in vesicle trafficking and its association with neurological disorders could provide insights into potential therapeutic targets for treating conditions related to abnormal membrane trafficking and vesicle formation. Additionally, ARFGEF2 may be an attractive candidate for drug development targeted towards modulating cellular processes reliant on ARF1 activation.

Is ARFGEF2 protein involved in any specific cellular processes? 07/21/2019

Yes, ARFGEF2 has been implicated in various cellular processes such as vesicle budding, trafficking, and fusion, as well as membrane remodeling and cytoskeletal organization.

Can alterations in ARFGEF2 expression or activity contribute to cancer development? 05/14/2019

While further research is required, some studies suggest that dysregulation of ARFGEF2 expression or activity may promote tumor progression and metastasis by affecting vesicle trafficking and membrane dynamics. However, the exact mechanisms and implications of ARFGEF2 in cancer development remain to be fully elucidated.

How is ARFGEF2 protein regulated in the cell? 02/17/2019

ARFGEF2 activity is tightly regulated by multiple mechanisms. It can be regulated through post-translational modifications such as phosphorylation and sumoylation. Additionally, its activity can be modulated by interacting with regulatory proteins or through changes in subcellular localization.

Are there any known interacting partners of ARFGEF2? 08/17/2018

Yes, ARFGEF2 interacts with multiple proteins involved in vesicle trafficking and signaling pathways. Some known interacting partners include ARF GTPases, Rho GTPases, SNARE proteins, protein kinases (such as ROCK and PKC), and phosphatases (such as PP2A). Additional interacting partners may be identified through further research.

Are there any diseases associated with ARFGEF2 protein mutations? 05/07/2018

Yes, mutations in the ARFGEF2 gene have been implicated in neurological disorders such as autosomal recessive pontocerebellar hypoplasia (PCH). PCH is characterized by underdevelopment of the brainstem and cerebellum, leading to severe developmental delays and neurological deficits.

Are there any diseases or disorders associated with ARFGEF2 dysfunction? 01/26/2018

Mutations in the ARFGEF2 gene have been identified in individuals with neurodevelopmental disorders such as intellectual disability and autism spectrum disorders. These mutations disrupt the proper function of ARFGEF2, leading to impaired neuronal development and function. Additionally, altered expression or activity of ARFGEF2 has been implicated in cancers, including breast cancer and hepatocellular carcinoma, suggesting its potential involvement in tumorigenesis.

In which cellular compartments does ARFGEF2 protein primarily function? 03/17/2017

ARFGEF2 is primarily located in the Golgi apparatus and endosomes, where it regulates vesicle trafficking between these compartments.

Can ARFGEF2 be targeted for therapeutic interventions? 01/18/2017

Although there are no specific therapeutics targeting ARFGEF2 currently available, its involvement in various cellular processes and disease-related pathways makes it a potential target for drug development. Future studies may identify specific inhibitors or modulators of ARFGEF2 that could be utilized for therapeutic interventions in relevant diseases.

Does ARFGEF2 protein have any known interactions with other proteins? 12/11/2016

Yes, ARFGEF2 has been found to interact with various proteins involved in vesicle trafficking, including clathrin, AP-1, AP-3, and the COPI coat complex.

How does ARFGEF2 contribute to neuronal migration? 05/04/2016

ARFGEF2 is involved in neuronal migration by regulating the dynamics of the cytoskeleton. It promotes the formation of membrane protrusions, such as lamellipodia and filopodia, which are necessary for the movement of migrating neurons. ARFGEF2 activates Rho GTPases, such as Rac1 and Cdc42, which in turn regulate actin polymerization and cytoskeletal reorganization required for neuronal migration.

Customer Reviews (8)

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Reviews
07/08/2022

    The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.

    02/11/2022

      he ARFGEF2 protein is an exceptional choice that meets the highest standards of quality, perfectly catering to my experimental requirements.

      09/06/2020

        the manufacturer's commitment to quality control and product development is admirable.

        05/02/2019

          Whether studying its role in cell adhesion, signal transduction, or host-pathogen interactions, the ARFGEF2 protein consistently delivers reliable and reproducible results.

          03/02/2018

            the ARFGEF2 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.

            08/20/2017

              Their expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.

              11/02/2016

                This level of support has been invaluable in optimizing my protocols and ensuring the success of my experiments.

                01/19/2016

                  Their rigorous testing procedures and attention to detail guarantee the consistency and reliability of the ARFGEF2 protein across different batches.

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