arhgap6
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  • Official Full Name
  • Rho GTPase activating protein 6
  • Background
  • This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ARHGAP6; Rho GTPase activating protein 6; rho GTPase-activating protein 6; rhoGAPX 1; ARHGAP 6; Rho type GTPase activating protein RhoGAPX 1; RHOGAP 6; RHOGAP6; RhoGAPX1; OTTHUMP00000022913; OTTHUMP00000022915; OTTHUMP00000022916; OTTHUMP00000022917; OTTHUMP00000022918; OTTHUMP00000236431; rho-type GTPase-activating protein 6; Rho-type GTPase-activating protein RhoGAPX-1; RHOGAPX-1
Cat.#:ARHGAP6-2704HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ARHGAP6 Protein, MYC/DDK-tagged
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Cat.#:ARHGAP6-772HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARHGAP6 protein, GST-tagged
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Cat.#:ARHGAP6-1880MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ARHGAP6 Protein
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Cat.#:ARHGAP6-4011ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ARHGAP6
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Involved Pathway

ARHGAP6 involved in several pathways and played different roles in them. We selected most pathways ARHGAP6 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rho GTPase cycle
ARHGAP33; ARHGEF3; ARHGAP1; DEPDC1B; ARHGAP6; ARHGAP20; TAGAP1; FAM13A; RHOT1; FGD4A
Signal Transduction
PROKR2; EDNRAB; RGS7; TTC21B; FAM13A; ADCYAP1B; TAS2R7; OXGR1A.2; STRAP; RIT2
Signaling by Rho GTPases
CHN2; RHOT2; NCKIPSD; FGD4A; DLC1; RHOUA; ARHGAP44; ARHGAP26; PRC1; RHOJ

Protein Function

ARHGAP6 has several biochemical functions, for example, GTPase activator activity, SH3 domain binding, phospholipase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP6 itself. We selected most functions ARHGAP6 had, and list some proteins which have the same functions with ARHGAP6. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein RGS9A; RASA4; GDI1; ABR; FAM13B1; IQGAP3; TBC1D30; SMAP1; NCKAP1L; DOCK1
Function SH3 domain binding
Related Protein SIRPA; NCKIPSD; PTPN22; ADAM17; QKI; SH3BGRL2; USP8; INPPL1B; CD3E; ELMO2
Function phospholipase activator activity
Related Protein GM2A; APOC2; CCL5; CCL8; PDPK1; ARHGAP6; CCL3
Function phospholipase binding
Related Protein CALM1; LMNB1; SELE; PTPN11; SERPINB1A; CALM2; SNCA; CALM3; PRKCZ; PDPK1