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Recombinant Mouse ARHGAP6 Protein

Cat.No. : ARHGAP6-1880M
Product Overview : Recombinant Mouse ARHGAP6 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Arhgap6 Rho GTPase activating protein 6 [ Mus musculus ]
Official Symbol : ARHGAP6
Gene ID : 11856
mRNA Refseq : NM_009707.3
Protein Refseq : NP_033837.2
MIM :
UniProt ID : O54834

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (21)

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Are there any known regulators of ARHGAP6 expression or activity? 01/11/2023

The precise regulators of ARHGAP6 expression and activity are not well-characterized. However, studies have suggested that various signaling pathways and transcription factors may influence ARHGAP6 expression. For example, TGF-beta signaling has been implicated in the upregulation of ARHGAP6 expression in certain cancer cells. Additionally, the transcription factor AP-1 has been shown to bind to the ARHGAP6 promoter and regulate its expression. Further studies are needed to uncover additional regulators and signaling pathways that modulate ARHGAP6 expression and activity.

What are some other cellular processes that ARHGAP6 is involved in? 12/06/2022

In addition to cell migration, adhesion, and cytoskeletal dynamics, ARHGAP6 has been implicated in other cellular processes as well. It is involved in regulating cell proliferation, cell cycle progression, and cell polarity. ARHGAP6 may also play a role in cell signaling pathways, including those related to growth factor receptors and integrin signaling. Its precise functions in these processes are still being elucidated and may vary depending on the cellular context.

Does ARHGAP6 have any roles in cardiovascular health? 09/30/2022

The roles of ARHGAP6 in cardiovascular health have not been extensively studied. However, some studies have suggested potential involvement of ARHGAP6 in endothelial cell migration and angiogenesis, which are critical for blood vessel formation. ARHGAP6 may also play a role in vascular permeability and inflammation. Further research is needed to fully understand the contributions of ARHGAP6 to cardiovascular health and disease.

What are the potential downstream effects of ARHGAP6 dysregulation? 04/30/2022

Dysregulation of ARHGAP6 can result in altered Rho GTPase activity, potentially affecting various cellular processes. This could lead to changes in cytoskeletal dynamics, cell migration, cell adhesion, and signaling pathways that are regulated by Rho GTPases.

Can ARHGAP6 be a potential therapeutic target for cancer treatment? 04/12/2022

Further investigation is required to determine the therapeutic potential of targeting ARHGAP6 in cancer. However, its involvement in cancer cell migration and invasion suggests that modulating its activity or expression could potentially be explored as a therapeutic strategy.

Can ARHGAP6 be used as a diagnostic marker? 02/27/2022

ARHGAP6's potential as a diagnostic marker for diseases has not been extensively explored. However, its dysregulation in certain cancers suggests that it could potentially be investigated as a diagnostic marker in the future. Additional research is required to validate its diagnostic utility.

Does ARHGAP6 play a role in embryonic development? 12/17/2021

The role of ARHGAP6 in embryonic development is not well-documented. However, studies have suggested potential involvement of ARHGAP6 in processes such as neural tube closure and craniofacial development. ARHGAP6 has been found to be expressed in developing tissues and organs during embryogenesis. Further research is needed to determine the precise contributions of ARHGAP6 to embryonic development.

Is ARHGAP6 involved in any other cellular processes or diseases? 03/16/2021

While its role in cancer metastasis is well-documented, research on ARHGAP6's involvement in other cellular processes or diseases is limited. Further studies are needed to explore its function in areas such as cell adhesion, cytoskeletal dynamics, and potential associations with other diseases.

Is there any association between ARHGAP6 and diseases? 03/13/2021

Current research suggests that dysregulation of ARHGAP6 may be associated with certain diseases. For example, abnormal expression or activity of ARHGAP6 has been implicated in cancer metastasis, where it plays a role in cancer cell migration and invasion.

Is ARHGAP6 localized to specific cellular compartments? 03/04/2021

ARHGAP6 is predominantly localized to the cytoplasm, where it interacts with Rho GTPases. However, it may also be present in other cellular compartments, such as the plasma membrane or intracellular organelles, depending on the specific cellular context and function.

Are there any specific types of cancer associated with ARHGAP6 dysregulation? 09/27/2020

ARHGAP6 dysregulation has been observed in various types of cancers, including breast cancer, ovarian cancer, and pancreatic cancer. Increased ARHGAP6 expression has been linked to cancer cell invasion and metastasis in these malignancies.

Are there any small molecule inhibitors or activators of ARHGAP6? 01/22/2020

Currently, there are no well-established small molecule inhibitors or activators specifically targeting ARHGAP6. However, there are compounds that target Rho GTPases, which indirectly affect the activity of ARHGAP6. These compounds can modulate the activity of Rho GTPases and, consequently, the downstream effects of ARHGAP6 on cellular processes. Further research and the development of specific ARHGAP6 modulators are necessary for targeted modulation of ARHGAP6 activity.

Are there any genetic mutations associated with ARHGAP6? 03/05/2019

Currently, there is limited research on ARHGAP6 mutations. However, genomic studies have identified genetic variations in the ARHGAP6 gene in certain cancers and other diseases. These mutations could potentially influence ARHGAP6 function and contribute to disease progression.

Are there any animal models or cell lines used to study ARHGAP6? 06/30/2018

Yes, various animal models and cell lines have been utilized to study ARHGAP6. These include genetically modified mouse models, such as knockout or overexpression models, as well as cell lines derived from different tissues or cancers to investigate its functional roles and effects on cellular processes.

Can ARHGAP6 be regulated by post-translational modifications? 02/06/2018

Yes, ARHGAP6 can be regulated by post-translational modifications. Phosphorylation of ARHGAP6 has been shown to modulate its activity and subcellular localization. For example, phosphorylation by protein kinase C (PKC) enhances ARHGAP6 activity and its association with the plasma membrane. Other post-translational modifications, such as acetylation or ubiquitination, may also play a role in regulating ARHGAP6 function, although these have not been extensively studied. Further research is needed to uncover additional post-translational modifications and their effects on ARHGAP6.

How does ARHGAP6 regulate Rho GTPases? 10/12/2017

ARHGAP6 functions as a GTPase-activating protein (GAP) for specific Rho GTPases. It binds to the activated form of Rho GTPases and stimulates their intrinsic GTPase activity, leading to the hydrolysis of GTP into GDP and subsequent inactivation of Rho GTPases.

Does ARHGAP6 interact with other proteins? 07/11/2017

Yes, ARHGAP6 interacts with various proteins to carry out its functions. It has been found to interact with Rho GTPases, such as RhoA and Rac1, through its Rho-GAP domain, allowing it to regulate their activity. ARHGAP6 also interacts with other proteins involved in cytoskeletal dynamics and cell adhesion, such as actin-binding proteins and focal adhesion proteins. These protein-protein interactions are important for the proper functioning of ARHGAP6 and its role in cellular processes.

Are there any known interacting partners of ARHGAP6? 05/22/2017

ARHGAP6 has been reported to interact with various proteins, including Rho GTPases such as RhoA and Rac1. It may also interact with other regulatory proteins involved in cytoskeletal dynamics and cell signaling pathways. Further research is needed to fully elucidate its interacting partners.

Does ARHGAP6 have any roles in immune cell function? 04/22/2017

The role of ARHGAP6 in immune cell function has not been extensively studied but emerging evidence suggests its involvement. In T-cells, ARHGAP6 has been shown to regulate T-cell receptor signaling and T-cell activation. It may also play a role in dendritic cell migration and antigen presentation. However, further research is needed to fully understand the extent of ARHGAP6's contributions to immune cell function.

Is ARHGAP6 expression tissue-specific? 11/29/2016

ARHGAP6 is expressed in a wide range of tissues; however, the levels of expression may vary between different tissues or cell types. Further studies are needed to determine if ARHGAP6 expression is precisely tissue-specific or if it exhibits specific patterns in different tissues or organs.

Are there any drugs or compounds known to target ARHGAP6? 08/13/2016

Currently, there are no known specific drugs or compounds that directly target ARHGAP6. However, as research on ARHGAP6 and its role in disease progresses, it is possible that drugs or therapeutic agents targeting the protein or its downstream signaling pathways may be developed in the future.

Customer Reviews (8)

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Reviews
11/17/2022

    Their ability to accommodate the requirements of large-scale experiments and guarantee a reliable supply streamlines my research operations, eliminating any concerns related to potential shortages.

    10/09/2021

      the manufacturer's commitment to delivering the ARHGAP6 protein in a timely manner is greatly appreciated.

      04/13/2021

        I am confident that the protein will reliably perform in my assays, providing accurate and reproducible results.

        01/04/2021

          Their prompt and knowledgeable assistance has the potential to solve any difficulties I may encounter during my experiments.

          08/16/2020

            the manufacturer's supply management capabilities assure a seamless and continuous provision of the ARHGAP6 protein.

            10/25/2019

              The cost-effectiveness of the ARHGAP6 protein, competitive pricing, and the availability of bulk purchase options provided by the manufacturer also align with my budget considerations, allowing me to optimize my resources.

              10/06/2017

                the manufacturer's supply management capabilities assure a seamless and continuous provision of the ARHGAP6 protein.

                10/26/2016

                  I am confident that my experimental needs will be met through their assistance, ensuring successful outcomes in my trials.

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