arhgef15
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  • Official Full Name
  • Rho guanine nucleotide exchange factor (GEF) 15
  • Background
  • Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene.
  • Synonyms
  • ARHGEF15; Rho guanine nucleotide exchange factor (GEF) 15; rho guanine nucleotide exchange factor 15; ARGEF15; FLJ13791; KIAA0915; MGC44868; Rho guanine exchange factor (GEF) 15; Vsm RhoGEF; ephexin-5; Rho GEF 15; E5; Ephexin5; Vsm-RhoGEF
Cat.#:ARHGEF15-889HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ARHGEF15
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Cat.#:ARHGEF15-8733HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ARHGEF15 293 Cell Lysate
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Involved Pathway

ARHGEF15 involved in several pathways and played different roles in them. We selected most pathways ARHGEF15 participated on our site, such as EPHA forward signaling, Regulation of RhoA activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF15 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
EPHA forward signaling
EFNA3; EPHA2; EFNA5; EFNA2; EFNA1; BLK; CRKL; ARHGEF15
Regulation of RhoA activity
ARHGEF10L; ARHGEF3; MYO9B; MCF2L; ARHGEF10; AKAP13; DLC1; DEF6; NET1; ARHGAP9

Protein Function

ARHGEF15 has several biochemical functions, for example, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF15 itself. We selected most functions ARHGEF15 had, and list some proteins which have the same functions with ARHGEF15. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein DEPDC1B; RACGAP1; RAP1GDS1; ARHGAP36; ARAP3; RGS17; NCKAP1L; RP2; LLGL2; ARHGAP28
Function Rho guanyl-nucleotide exchange factor activity
Related Protein PREX1; PLEKHG6; SOS1; ITSN2; NET1; ARHGEF15; DCLRE1B; PLEKHG2; C3A.1; FGD4
Function protein binding
Related Protein COL6A5; AKAP5; VPREB1; MAT2A; KLRC1; SERPINA1; ORAI1; CXCR2; CTNNB1; ARHGEF16

Interacting Protein

ARHGEF15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF15.
C11orf49; MOB4