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ARHGEF28

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 28

  • Overview

    This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.
  • Synonyms

    ARHGEF28; RIP2; RGNEF; p190RHOGEF; Rho guanine nucleotide exchange factor (GEF) 28; rho guanine nucleotide exchange factor 28; p190-RhoGEF; Rho interacting protein 2; rho-guanine nucleotide exchange factor; 190 kDa guanine nucleotide exchange factor;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGEF28-540HCL Recombinant Human ARHGEF28 lysate HEK293 N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARHGEF28 involved in several pathways and played different roles in them. We selected most pathways ARHGEF28 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceDUSP10;HFE2;RAC3;ARPC1B;DPYSL4;KCNQ3;SEMA4C;ADAM10;ANK2B
Developmental BiologySPNA1;KALRN;ARPC1B;DNM1;DUSP4;KCNQ3;PEA15A;FOXH1;NADL1.1
EPH-Ephrin signalingACTR3;AP2S1;EPHB4B;EPHB3A;EPHA2A;EFNA2;EFNB2A;CFL1;MYL12A
EPHB-mediated forward signalingEPHB4A;ACTR3;ARHGEF28;ARPC1B;ACTR2B;ARPC3;EPHB4B;ARPC1A;ARPC2
Regulation of RhoA activityAKAP13;DEF6;ARHGAP4;ARHGEF10;ARHGEF28;OBSCN;ARHGEF3;ARHGAP9;ARHGEF10L
Signaling events mediated by focal adhesion kinaseARHGAP26;KLF8;BMX;ACTA1;ARHGEF28

ARHGEF28 has several biochemical functions, for example, RNA binding, Rho guanyl-nucleotide exchange factor activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF28 itself. We selected most functions ARHGEF28 had, and list some proteins which have the same functions with ARHGEF28. You can find most of the proteins on our site.

Function Related Protein
RNA bindingAHCYL1;TIAL1;LRPPRC;ELAVL1;SUZ12;THUMPD3;BXDC2;CPSF5;AGO3B
Rho guanyl-nucleotide exchange factor activityARHGEF37;ARHGEF16;C3A.1;TRIOA;ARHGEF40;TRIO;ARHGEF11;ARHGEF25;PLEKHG7
metal ion bindingZNF493;TRIM105;PCK2;ZNF711;GNAS;TDRD1;POLD1;CASZ1;PRKCI

ARHGEF28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF28 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF28.

q9wmx2-pro_0000037548

  • Q&As
  • Reviews

Q&As (11)

Ask a question
Is there any information available about the subcellular localization of ARHGEF28? 06/17/2022

Limited information is available regarding the subcellular localization of ARHGEF28. It is suggested to be mainly localized in the cytoplasm, but further studies are needed to confirm and elucidate its precise subcellular localization.

Has ARHGEF28 been implicated in any developmental processes? 01/16/2022

The involvement of ARHGEF28 in developmental processes has not been extensively studied. Future research may shed light on its potential role during development.

Has any research been conducted on the tissue distribution of ARHGEF28? 01/09/2022

Studies on the tissue distribution of ARHGEF28 are scarce. Further investigations are required to determine its expression pattern across various tissues.

Are there any known protein interactors of ARHGEF28? 05/30/2021

The protein interactors of ARHGEF28 have not been extensively studied. More research is needed to identify its potential interaction partners and elucidate its molecular mechanisms.

Has ARHGEF28 been investigated in any animal models or in vivo studies? 12/09/2019

ARHGEF28 has not been extensively investigated in animal models or in vivo studies. Further research is required to explore its roles and functions in various animal models and physiological contexts.

Are there any known functional assays or experimental approaches to study ARHGEF28? 02/02/2018

There are currently no widely established functional assays or experimental approaches specific to studying ARHGEF28. Researchers may employ a variety of techniques, such as knockdown or overexpression experiments, to assess its potential functions or roles in specific cellular processes.

Is ARHGEF28 involved in any specific physiological processes or cellular functions? 12/08/2017

The specific physiological processes and cellular functions associated with ARHGEF28 are unknown. Further investigations are required to determine its involvement in various biological contexts.

Are there any known alternative splicing isoforms of ARHGEF28? 10/30/2017

The existence of alternative splicing isoforms for ARHGEF28 has not been reported in current literature. However, future research may uncover the presence of alternative variants and their potential functional implications.

Has ARHGEF28 been studied in the context of neuronal development or neurodegenerative diseases? 08/15/2017

There is currently limited information about the involvement of ARHGEF28 in neuronal development or neurodegenerative diseases. Future investigations may reveal its potential roles in these contexts.

Has ARHGEF28 been studied in non-human organisms? 03/10/2017

Limited studies have investigated ARHGEF28 in non-human organisms. For example, one study in mice demonstrated its expression in the brain and its potential involvement in regulating dendritic spine morphology. Further research in non-human organisms may provide additional insights into the function of ARHGEF28.

Are there any diseases or conditions associated with ARHGEF28 dysregulation? 06/09/2016

There are no known diseases or conditions specifically associated with ARHGEF28 dysregulation at present. However, with additional studies, potential links to certain diseases or conditions may be discovered.

Customer Reviews (8)

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Reviews
03/10/2022

    Its high-quality standards guarantee reliable and reproducible results, enabling me to draw robust conclusions from my research.

    10/04/2020

      This dedication ensures that I have access to the most advanced and reliable protein in my studies, enhancing the overall quality and impact of my research outcomes.

      09/25/2020

        This exceptional level of support enables me to overcome challenges efficiently and progress smoothly with my research.

        02/09/2020

          The ARHGEF28 protein is of exceptional quality, meeting all my experimental requirements with precision and reliability.

          06/02/2019

            Considering the cost-effectiveness of the ARHGEF28 protein and the competitive pricing offered by the manufacturer, it aligns perfectly with my budget constraints.

            07/11/2018

              the ARHGEF28 protein, coupled with the manufacturer's excellent technical support, provides an ideal solution for my experimental needs.

              05/02/2016

                In addition to the protein's quality and technical support, the manufacturer's commitment to timely delivery and efficient supply chain management ensures that I receive the ARHGEF28 protein promptly, minimizing any potential delays in my research schedule.

                04/13/2016

                  One of the standout advantages offered by the manufacturer is their excellent technical support.

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