arhgef28
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  • Official Full Name
  • Rho guanine nucleotide exchange factor (GEF) 28
  • Background
  • This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.
  • Synonyms
  • ARHGEF28; RIP2; RGNEF; p190RHOGEF; Rho guanine nucleotide exchange factor (GEF) 28; rho guanine nucleotide exchange factor 28; p190-RhoGEF; Rho interacting protein 2; rho-guanine nucleotide exchange factor; 190 kDa guanine nucleotide exchange factor
Cat.#:ARHGEF28-540HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ARHGEF28 lysate
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Involved Pathway

ARHGEF28 involved in several pathways and played different roles in them. We selected most pathways ARHGEF28 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
SEMA3AA; SPTBN1; NTN1A; ABLIM3; PAQR3B; FRS2B; PITPNA; PPP3CC; SEMA3C; CSF2RA
Developmental Biology
EFNB3; COL4A3; AP2A1; PHB; LIN28A; INSM1B; NRG2A; RASGEF1A; MYL9; CNTN6
EPH-Ephrin signaling
CFL1; KALRN; ITSN1; AP2B1; EPHA10; SHB; EFNB3B; EFNA3B; CLTC; EPHB4A
EPHB-mediated forward signaling
KALRN; EFNB1; ACTR2; ARPC4; ACTR2B; ARPC1B; CFL1; EPHB3A; ITSN1; ARPC3
Regulation of RhoA activity
ARHGEF25; ARHGAP9; ECT2; MCF2L; OBSCN; ARHGAP4; ARHGEF18; NET1; MYO9B; ARHGEF28
Signaling events mediated by focal adhesion kinase
ACTA1; BMX; ARHGAP26; ARHGEF28; KLF8

Protein Function

ARHGEF28 has several biochemical functions, for example, RNA binding, Rho guanyl-nucleotide exchange factor activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF28 itself. We selected most functions ARHGEF28 had, and list some proteins which have the same functions with ARHGEF28. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein ZNF385D; KHDRBS1B; TIAL1; THOC5; PPP5C; SUPV3L1; PCBP1; TRIM32; HBP1; NCL
Function Rho guanyl-nucleotide exchange factor activity
Related Protein DOCK11; FGD3; ARHGEF1A; ITSN2; ARHGEF16; ARHGEF7A; ITSN2A; PLEKHG6; FARP2; ARHGEF10L
Function metal ion binding
Related Protein FDPS; CYP46A1.3; CYP2J6; PPP1CB; GNPTAB; CYP3C1L2; TREX1; PLEKHM3; HBAE3; ASAP2

Interacting Protein

ARHGEF28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF28 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF28.
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