ARID5B
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Official Full Name
AT rich interactive domain 5B (MRF1-like)
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Synonyms
ARID5B; AT rich interactive domain 5B (MRF1-like); AT-rich interactive domain-containing protein 5B; FLJ21150; MRF2; MRF1-like protein; ARID domain-containing protein 5B; modulator recognition factor 2 (MRF2); DESRT; MRF-2; FLJ41888;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Zebrafish
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ARID5B-798H | Recombinant Human ARID5B protein, GST-tagged | Wheat Germ | GST | ||
Mouse | ARID5B-1917M | Recombinant Mouse ARID5B Protein | Mammalian Cell | His | ||
Mouse | ARID5B-712M | Recombinant Mouse ARID5B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ARID5B-712M-B | Recombinant Mouse ARID5B Protein Pre-coupled Magnetic Beads | HEK293 | |||
Bovine | ARID5B-3682B | Recombinant Bovine ARID5B, His-tagged | E.Coli or Yeast | His | 1173 | |
Zebrafish | ARID5B-5057Z | Recombinant Zebrafish ARID5B | Mammalian Cell | His | ||
Chicken | ARID5B-2882C | Recombinant Chicken ARID5B | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ARID5B involved in several pathways and played different roles in them. We selected most pathways ARID5B participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARID5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Chromatin modifying enzymes | WDR77;ELP2;SMARCA4;PHF21A;KDM2AA;DR1;RBBP5;MCRS1;JADE1 |
Chromatin organization | ARID5B;RBBP7;KDM2A;ENY2;ARID2;KDM4A;SMARCA2;SUZ12A;PADI4 |
HDMs demethylate histones | KDM7AB;KDM3A;ARID5B;KDM4B;KDM5BB;KDM6B;KDM5B;KDM4C;KDM2B |
ARID5B has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, contributes_to transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARID5B itself. We selected most functions ARID5B had, and list some proteins which have the same functions with ARID5B. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | DNASE2;ZNF202;BRIP1;ZFP641;HIST1H4A;DMBX1B;EXO1;HIST3H2A;Alb |
RNA polymerase II regulatory region sequence-specific DNA binding | PRDM15;NFIL3;ZNF561;BCL6AB;EOMES;PHF21B;FOXD3;ZNF79;SKINT8 |
contributes_to transcription coactivator activity | PHF2;EP300;CREBBP;ARID5B |
transcription regulatory region DNA binding | TCF7L2;GFI1;SIX1;CALCOCO1;THRA;BCL11AB;SOX2;FOXH1;FOXM1 |
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | FERD3L;ISX;SNAI3;VAX1;HES6;GLIS1;HIST2H3A;MSX2;CSDA |
ARID5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARID5B here. Most of them are supplied by our site. Hope this information will be useful for your research of ARID5B.
Nanog
- Q&As
- Reviews
Q&As (12)
Ask a questionNo, ARID5B is expressed in various tissues and cell types throughout the body. Its expression pattern can vary depending on the developmental stage and physiological conditions. ARID5B has been detected in different organs, including the brain, heart, liver, lungs, kidneys, and immune cells. It plays important roles in the development and function of these tissues, as well as in the regulation of immune responses and inflammatory processes.
Targeting ARID5B could potentially be beneficial in the treatment of immune-related disorders. By altering the activity or expression of ARID5B, it may be possible to modulate immune responses and dampen excessive inflammatory reactions seen in certain autoimmune diseases. However, more research is needed to understand the precise mechanisms by which ARID5B regulates immune responses and to develop strategies for specifically targeting its activity in a therapeutic context.
Current research on ARID5B is focused on understanding its molecular mechanisms, identifying additional interacting partners, and deciphering its specific roles in different biological processes. Scientists are also investigating the genetic variations in ARID5B and their associations with diseases to gain insights into potential therapeutic approaches. Furthermore, the development and optimization of experimental models and techniques to study ARID5B function are areas of active research.
Currently, there are no drugs or compounds specifically designed to target ARID5B. However, ongoing research may identify potential candidates for modulating ARID5B activity. Small molecules or compounds that can inhibit or activate ARID5B function could be explored for their therapeutic potential in diseases where ARID5B dysregulation is implicated.
Yes, genetic variations in the ARID5B gene have been linked to various diseases and traits. In particular, single nucleotide polymorphisms (SNPs) in the ARID5B gene have been associated with an increased risk of developing pediatric acute lymphoblastic leukemia (ALL) and susceptibility to other hematological malignancies. Additionally, certain ARID5B SNPs have been associated with altered height, body mass index, and other developmental traits.
ARID5B has been associated with increased susceptibility to certain types of cancers, particularly hematological malignancies such as acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), and Hodgkin's lymphoma. However, the exact mechanisms by which ARID5B contributes to cancer development and progression are not fully understood. It is believed that ARID5B may influence cell proliferation, apoptosis, and other processes involved in tumor growth. Further investigation is needed to fully characterize ARID5B's role in cancer and its potential as a therapeutic target.
Targeting ARID5B could have therapeutic implications in certain diseases, particularly in pediatric acute lymphoblastic leukemia (ALL), where ARID5B SNPs are strongly associated with increased risk. Understanding the precise role of ARID5B in leukemogenesis could help develop targeted therapies or personalized treatment strategies. Additionally, since ARID5B is involved in regulating immune responses and inflammatory processes, modulating its activity or expression might have therapeutic potential in immune-related disorders and certain cancers where ARID5B dysregulation is observed.
ARID5B has been found to play a role in modulating immune responses and inflammatory processes. It has been shown to regulate the expression of various cytokines and chemokines, which are key molecules involved in immune and inflammatory responses. ARID5B can directly bind to the promoter regions of target genes and either activate or repress their transcription, thus influencing the release of inflammatory mediators. By doing so, ARID5B helps to fine-tune the immune response and maintain immune homeostasis.
Yes, mutations or genetic variations in ARID5B have been associated with several diseases. The strongest association is found with pediatric acute lymphoblastic leukemia (ALL), where certain ARID5B SNPs increase the risk of developing the disease. Additionally, ARID5B variants have been linked to an increased risk of other hematological malignancies, including chronic lymphocytic leukemia (CLL) and Hodgkin's lymphoma. Moreover, some studies have reported associations between ARID5B SNPs and susceptibility to asthma and autoimmune diseases.
While there may be ongoing studies and clinical trials investigating ARID5B, it is important to consult databases such as ClinicalTrials.gov or scientific literature to get the most up-to-date information. These resources can provide details on studies that specifically target ARID5B or analyze its role in specific diseases.
While the primary role of ARID5B is as a transcription factor, there is evidence suggesting that ARID5B may have additional functions. Some studies have implicated ARID5B in modulating cell proliferation, apoptosis (programmed cell death), and DNA damage response pathways. However, further research is needed to fully elucidate the extent of ARID5B's involvement in these processes and its underlying molecular mechanisms.
Yes, ARID5B is known to interact with various proteins to carry out its functions. It has been reported to interact with components of chromatin remodeling complexes, such as SWI/SNF, which modulate gene expression by altering chromatin structure. ARID5B also interacts with other transcription factors, such as GATA1 and PU.1, to regulate target gene expression in a cooperative manner.
Customer Reviews (6)
Write a reviewThis collaborative partnership facilitates a seamless and efficient research process, as the manufacturer aligns their support and services with my unique requirements.
With ARID5B protein, researchers can visualize protein complexes and their interactions with remarkable clarity, unraveling important insights into their functional mechanisms.
ARID5B protein has proven to be instrumental in protein electron microscopy structure analysis.
the manufacturer's commitment to ongoing innovation ensures that I have access to the most advanced and updated versions of the ARID5B protein.
This protein demonstrates exceptional performance in ELISA, delivering accurate and reliable results in the detection and quantification of specific antigens.
They proactively monitor scientific advancements and customer feedback to continually refine and improve the performance of the protein.
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