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ARPC3

  • Official Full Name

    actin related protein 2/3 complex, subunit 3, 21kDa

  • Overview

    This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined.
  • Synonyms

    ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa; actin related protein 2/3 complex, subunit 3 (21 kD); actin-related protein 2/3 complex subunit 3; ARC21; p21 Arc; Actin related protein 2/3 complex subunit 3; ARP2/3 complex 21 kDa subunit; ARP2/3 protein complex subunit p21; p21-Arc;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARPC3-7591H Recombinant Human ARPC3, His-tagged E.coli His 1-178aa
Human ARPC3-9884H Recombinant Human ARPC3, GST-tagged E.coli GST 1-178a.a.
Human ARPC3-847H Recombinant Human ARPC3 protein, GST-tagged Wheat Germ GST
Human ARPC3-37HCL Recombinant Human ARPC3 lysate HEK293 N/A
Human ARPC3-1101HF Recombinant Full Length Human ARPC3 Protein, GST-tagged In Vitro Cell Free System GST 178 amino acids
Human ARPC3-151H Recombinant Human ARPC3 Protein, His-tagged Human Cells His
Human ARPC3-2793H Recombinant Human ARPC3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ARPC3-5195H Recombinant Human ARPC3 protein, GST-tagged E.coli GST 2-175aa
Human ARPC3-5659H Recombinant Human ARPC3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse ARPC3-1968M Recombinant Mouse ARPC3 Protein Mammalian Cell His
Mouse ARPC3-749M-B Recombinant Mouse ARPC3 Protein Pre-coupled Magnetic Beads HEK293
Mouse ARPC3-749M Recombinant Mouse ARPC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Arpc3-1726M Recombinant Mouse Arpc3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque ARPC3-417R Recombinant Rhesus monkey ARPC3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ARPC3-246R-B Recombinant Rhesus Macaque ARPC3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ARPC3-246R Recombinant Rhesus Macaque ARPC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ARPC3-342Z Recombinant Zebrafish ARPC3 Mammalian Cell His
Chicken ARPC3-4880C Recombinant Chicken ARPC3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARPC3 Related Articles

ARPC3 involved in several pathways and played different roles in them. We selected most pathways ARPC3 participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceNTN1;SCN3A;EPHB4;DNM1;RAC3;GFRA2;ABLIM2;SEMA3G;COL6A1
B Cell Receptor Signaling PathwayDUSP6;LCP2A;ACTR2;BANK1;ITK;MAPK4;CTNNB2;PLCG2;BLNK
Bacterial invasion of epithelial cellsRAC1;SHC1;CDC42;CTTN;ILK;SEPT11;SHC4;DOCK1;CBLB
CDC42 signaling eventsACTR3;ARPC5;BAIAP2;CDC42BPA;ACTR2;PAK4;CTNNA1;IQGAP3;ARPC1B
Developmental BiologyDPYSL5A;COL9A1B;CACNG2;ANK2B;FOXD3;COL9A1;NRTN;EPHB3A;PAQR3A
EPH-Ephrin signalingEFNA1;AP2B1;ACTR2B;DNM1;CLTC;EFNB3B;EFNA5;ARPC5;SDCBP
EPHB-mediated forward signalingARHGEF28;ACTR3;KALRNB;CFL1;KALRN;ARPC1B;EPHB3A;ARPC5;EPHB4A
EndocytosisIL2RGA;VPS35;TGFBR1;SH3GLB2;ACAP2;CLINT1A;SMAD3;ERBB3;PDCD6IP

ARPC3 has several biochemical functions, for example, contributes_to actin filament binding, protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC3 itself. We selected most functions ARPC3 had, and list some proteins which have the same functions with ARPC3. You can find most of the proteins on our site.

Function Related Protein
contributes_to actin filament bindingMYH10;ACTR3;ARPC3;ARPC4;MYH9;ARPC2;ARPC5;ARPC1B;ACTR2
protein bindingTRIM33;APOBEC2B;RTP2;CPNE1;PKMYT1;CACNG1;KIR2DL1;PTGDS;CCNL1
structural constituent of cytoskeletonKRT20;TUBGCP3;KRT17;TUBA1L2;EPB41;TUBB2;ACTL6B;ADD3;TUBGCP4

ARPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC3.

WASL; HOXA3; NRIP1; GOLGA2; VCAM1; Ptms; ACTR3B; LTA4H; CETP

Schmidt, S; Willers, J; et al. Effect of omega-3 polyunsaturated fatty acids on the cytoskeleton: an open-label intervention study. LIPIDS IN HEALTH AND DISEASE 14:-(2015).
Yang, WL; Thein, S; et al. Arp2/3 complex regulates adipogenesis by controlling cortical actin remodelling. BIOCHEMICAL JOURNAL 464:179-192(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
Is the ARPC3 protein essential for cell viability? 06/03/2022

Yes, the ARPC3 protein is essential for cell viability as it is a core component of the ARP2/3 complex, which is crucial for actin polymerization and cytoskeletal organization.

How is the ARPC3 protein involved in cellular processes? 05/03/2022

The ARPC3 protein is involved in a wide range of cellular processes that require actin dynamics, such as cell motility, endocytosis, cell division, and formation of cellular protrusions like lamellipodia and filopodia.

How can the ARPC3 protein be regulated? 01/09/2022

The ARPC3 protein can be regulated through various mechanisms. Factors such as phosphorylation, protein-protein interactions, and post-translational modifications can modulate its activity and influence actin dynamics in cells.

Can targeting the ARPC3 protein have therapeutic implications? 11/30/2021

Targeting the ARPC3 protein or the ARP2/3 complex could have potential therapeutic implications for diseases characterized by dysregulated actin dynamics, such as cancer metastasis, autoimmune disorders, and neurodegenerative diseases. Developing specific inhibitors or modulators of ARPC3 activity could be explored as potential therapeutic strategies.

Are there any known diseases associated with alterations in ARPC3 expression or function? 05/15/2020

Mutations or dysregulation of the ARPC3 gene have been linked to developmental disorders and genetic syndromes, including Baraitser-Winter syndrome and distal arthrogryposis.

Are there any known binding partners of the ARPC3 protein? 01/18/2020

The ARPC3 protein interacts with other components of the ARP2/3 complex, such as ARPC1, ARPC2, ARPC4, and ARPC5, to form a functional actin nucleation complex. It also interacts with various actin-binding proteins and regulators to mediate actin dynamics.

How can researchers study the ARPC3 protein in the laboratory? 10/20/2019

Researchers can study the ARPC3 protein by using techniques such as immunoblotting, immunofluorescence microscopy, co-immunoprecipitation, and gene knockout or knockdown approaches in cell culture models to assess its expression, localization, interactions, and functional effects.

Customer Reviews (3)

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Reviews
04/04/2021

    the ARPC3 protein finds great utility in protein electron microscopy structure analysis, consistently delivering exceptional results.

    11/15/2020

      Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.

      02/01/2020

        Its versatility and reliability make it an indispensable asset for scientists seeking to explore the complexities of various biological systems.

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