ARPC3
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Official Full Name
actin related protein 2/3 complex, subunit 3, 21kDa
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Overview
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined. -
Synonyms
ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa; actin related protein 2/3 complex, subunit 3 (21 kD); actin-related protein 2/3 complex subunit 3; ARC21; p21 Arc; Actin related protein 2/3 complex subunit 3; ARP2/3 complex 21 kDa subunit; ARP2/3 protein complex subunit p21; p21-Arc;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human Cells
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ARPC3 Related Articles
ARPC3 involved in several pathways and played different roles in them. We selected most pathways ARPC3 participated on our site, such as Axon guidance, B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Axon guidance | NTN1;SCN3A;EPHB4;DNM1;RAC3;GFRA2;ABLIM2;SEMA3G;COL6A1 |
B Cell Receptor Signaling Pathway | DUSP6;LCP2A;ACTR2;BANK1;ITK;MAPK4;CTNNB2;PLCG2;BLNK |
Bacterial invasion of epithelial cells | RAC1;SHC1;CDC42;CTTN;ILK;SEPT11;SHC4;DOCK1;CBLB |
CDC42 signaling events | ACTR3;ARPC5;BAIAP2;CDC42BPA;ACTR2;PAK4;CTNNA1;IQGAP3;ARPC1B |
Developmental Biology | DPYSL5A;COL9A1B;CACNG2;ANK2B;FOXD3;COL9A1;NRTN;EPHB3A;PAQR3A |
EPH-Ephrin signaling | EFNA1;AP2B1;ACTR2B;DNM1;CLTC;EFNB3B;EFNA5;ARPC5;SDCBP |
EPHB-mediated forward signaling | ARHGEF28;ACTR3;KALRNB;CFL1;KALRN;ARPC1B;EPHB3A;ARPC5;EPHB4A |
Endocytosis | IL2RGA;VPS35;TGFBR1;SH3GLB2;ACAP2;CLINT1A;SMAD3;ERBB3;PDCD6IP |
ARPC3 has several biochemical functions, for example, contributes_to actin filament binding, protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC3 itself. We selected most functions ARPC3 had, and list some proteins which have the same functions with ARPC3. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to actin filament binding | MYH10;ACTR3;ARPC3;ARPC4;MYH9;ARPC2;ARPC5;ARPC1B;ACTR2 |
protein binding | TRIM33;APOBEC2B;RTP2;CPNE1;PKMYT1;CACNG1;KIR2DL1;PTGDS;CCNL1 |
structural constituent of cytoskeleton | KRT20;TUBGCP3;KRT17;TUBA1L2;EPB41;TUBB2;ACTL6B;ADD3;TUBGCP4 |
ARPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC3.
WASL; HOXA3; NRIP1; GOLGA2; VCAM1; Ptms; ACTR3B; LTA4H; CETP
- Q&As
- Reviews
Q&As (7)
Ask a questionYes, the ARPC3 protein is essential for cell viability as it is a core component of the ARP2/3 complex, which is crucial for actin polymerization and cytoskeletal organization.
The ARPC3 protein is involved in a wide range of cellular processes that require actin dynamics, such as cell motility, endocytosis, cell division, and formation of cellular protrusions like lamellipodia and filopodia.
The ARPC3 protein can be regulated through various mechanisms. Factors such as phosphorylation, protein-protein interactions, and post-translational modifications can modulate its activity and influence actin dynamics in cells.
Targeting the ARPC3 protein or the ARP2/3 complex could have potential therapeutic implications for diseases characterized by dysregulated actin dynamics, such as cancer metastasis, autoimmune disorders, and neurodegenerative diseases. Developing specific inhibitors or modulators of ARPC3 activity could be explored as potential therapeutic strategies.
Mutations or dysregulation of the ARPC3 gene have been linked to developmental disorders and genetic syndromes, including Baraitser-Winter syndrome and distal arthrogryposis.
The ARPC3 protein interacts with other components of the ARP2/3 complex, such as ARPC1, ARPC2, ARPC4, and ARPC5, to form a functional actin nucleation complex. It also interacts with various actin-binding proteins and regulators to mediate actin dynamics.
Researchers can study the ARPC3 protein by using techniques such as immunoblotting, immunofluorescence microscopy, co-immunoprecipitation, and gene knockout or knockdown approaches in cell culture models to assess its expression, localization, interactions, and functional effects.
Customer Reviews (3)
Write a reviewthe ARPC3 protein finds great utility in protein electron microscopy structure analysis, consistently delivering exceptional results.
Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.
Its versatility and reliability make it an indispensable asset for scientists seeking to explore the complexities of various biological systems.
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