aspa
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  • Official Full Name
  • aspartoacylase
  • Background
  • This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate.;NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein;is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript;variants have been found for this gene.
  • Synonyms
  • ASPA; aspartoacylase; aspartoacylase (aminoacylase 2, Canavan disease); ACY2; aminoacylase 2; ASP; Canavan disease; ACY 2; ACY-2; ACY2_HUMAN; Aminoacylase-2; Aminoacylase2; Aspartoacylase (Canavan disease); NUR 7; NUR7; OTTMUSP00000006437; RP23-213I10.1; Small lethargic; OTTHUMP00000115814
Cat.#:ASPA-2438HTag:His|Myc
Source (Host):YeastSpecies:Human
Product nameRecombinant Human ASPA Protein (1-313 aa), His-Myc-tagged
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Cat.#:ASPA-1920HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aspartoacylase, His-tagged
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Cat.#:ASPA-162HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ASPA protein, MYC/DDK-tagged
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Cat.#:ASPA-163HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ASPA protein, MYC/DDK-tagged
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Cat.#:ASPA-873HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ASPA
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Cat.#:ASPA-916HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ASPA protein, GST-tagged
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Cat.#:ASPA-829RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ASPA Protein
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Cat.#:ASPA-317CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ASPA Protein, His-tagged
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Cat.#:ASPA-430RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ASPA Protein, His-tagged
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Cat.#:ASPA-6102ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ASPA
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Cat.#:ASPA-1339BTag:His
Source (Host):E. coli or YeastSpecies:Bacillus subtilis
Product nameRecombinant Bacillus subtilis ASPA protein, His-tagged
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Cat.#:ASPA-8647HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ASPA 293 Cell Lysate
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Involved Pathway

ASPA involved in several pathways and played different roles in them. We selected most pathways ASPA participated on our site, such as Alanine, aspartate and glutamate metabolism, Histidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alanine, aspartate and glutamate metabolism
GLULB; GOT2B; GLUD2; RIMKLB; ADSS; GLUD1B; GLULC; GLUD1A; ALDH5A1; ybaS
Histidine metabolism
ALDH7A1; FTCD; ALDH2.2; AOC1; ALDH1B1; ABP1; ALDH3B2; CNDP2; ASPA; ALDH9A1A.1
Metabolic pathways
ACSL4B; DLAT; NT5C; IL4I1; RDH10B; ATP6V0A1A; SDHD; CYP2J6; LIPCA; ATP6V1F

Protein Function

ASPA has several biochemical functions, for example, aminoacylase activity, aspartoacylase activity, hydrolase activity, acting on ester bonds. Some of the functions are cooperated with other proteins, some of the functions could acted by ASPA itself. We selected most functions ASPA had, and list some proteins which have the same functions with ASPA. You can find most of the proteins on our site.
Function
Related Protein
Function aminoacylase activity
Related Protein ASPA; DARS; CAT; ACY1; ACY3
Function aspartoacylase activity
Related Protein ASPA
Function hydrolase activity, acting on ester bonds
Related Protein ACY3.2; ACY3; ENDOU2; IAH1; APMAP; C11orf54; RAG1; ACY3.1; LIPK; SMFN
Function metal ion binding
Related Protein NRXN3; ZNF292B; CTDSP1; UBE3A; EXT1B; ZBTB9; C1GALT1A; EYA4; CISD2; ESRRGB
Function protein binding
Related Protein COL6A2; Itga10&Itgb1; CHCHD2; PURA; FAM207A; FLT1; DNAIC2; BANF1; IKZF2; TDG

Interacting Protein

ASPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASPA here. Most of them are supplied by our site. Hope this information will be useful for your research of ASPA.
ACY3

ASPA Related Articles

Chang, Z; Lu, M; et al. Production of disulfide bond-rich peptides by fusion expression using small transmembrane proteins of Escherichia coli. AMINO ACIDS 47:579-587(2015).
Abad, FX; Busquets, N; et al. Serological and virological surveys of the influenza A viruses in Antarctic and sub-Antarctic penguins. ANTARCTIC SCIENCE 25:339-344(2013).