ATP2A1
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Official Full Name
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
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Overview
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms. -
Synonyms
ATP2A1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; ATP2A; sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; calcium pump 1; SR Ca(2+)-ATPase 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; calcium-transporting ATPase sarcoplasm;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- Involved Pathway
- Protein Function
- Interacting Protein
- ATP2A1 Related Articles
ATP2A1 involved in several pathways and played different roles in them. We selected most pathways ATP2A1 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | ORAI1;SLC25A5;SLC8A1B;PDGFRB;ADRa1A;PRKACAA;DRD5;MYLK3;PDE1C |
| cGMP-PKG signaling pathway | GNAI1;FXYD2;RGS2;CALM2;PRKG2;ATP2A1;ATP1A3;ATP1A1;VDAC2 |
| Pancreatic secretion | SLC9A1;CELA2B;ATP1B4;CTRB1;BST1;CPA1;CA2;PNLIPRP2;PLA2G2F |
| Alzheimers disease | UQCR11;ATP5J;NDUFB7;NDUFA5;CYCS;UQCRQ;CALM2;COX5A;COX8C |
ATP2A1 has several biochemical functions, for example, ATP binding, calcium ion binding, calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2A1 itself. We selected most functions ATP2A1 had, and list some proteins which have the same functions with ATP2A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | GRK5;P2RX3;CSNK1DB;CUL9;CLCN3;NLRC4;MLH3;Aatk;PPP2R4 |
| calcium ion binding | CALR3;EFCAB1;CASQ1B;S100A13;PCDH2AB8;SYT5;CRNN;EGFL8;F10 |
| calcium-transporting ATPase activity | ATP2B1B;ATP2B1;ATP2B2;ATP2A1L;ATP2C2;ATP2A1;ATP2B4;ATP2B1A;ATP2A3 |
| protein binding | STT3A;NR1H3;SCP2;ZNF703;BARD1;IARS;TUT1;NR1D2;SPCS1 |
| protein homodimerization activity | CARD8;Anks6;GJC3;CBLN1;TIMM10;SDCBP;ERP29;DMRT1;CUBN |
ATP2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2A1.
TNFRSF1B; TULP3; RNF167; APPL1; 15-deoxy-delta(12,14
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, the expression and function of ATP2A1 recombinant protein in cardiomyocytes are regulated by different regulatory mechanisms, such as endogenous hormones and signaling pathways.
The recombinant ATP2A1 protein interacts with other proteins of the sarcoplasmic reticulum, such as calsequestrin and phospholamban, to regulate muscle contraction.
The ATP2A1 recombinant protein can be used as a drug target because it plays an important role in regulating muscle and cardiomyocyte function. However, there are no clinically applicable drugs targeting ATP2A1.
Impairment of the normal function of ATP2A1 recombinant protein in cardiomyocytes may contribute to the development of cardiovascular diseases, such as reduced myocardial contractility and heart failure.
Mutations in the ATP2A1 recombinant protein may cause calcium leakage and abnormal muscle contraction, leading to muscle diseases.
Certain drugs can affect the function of the recombinant ATP2A1 protein, such as calcium antagonists and cardiac agonists. These drugs regulate calcium homeostasis in muscle and cardiomyocytes.
Customer Reviews (3)
Write a reviewIt is noteworthy that the results of multiple experiments were highly consistent and reproducible.
The catalytic activity of ATP2A1 is very excellent, not only the catalytic effect is remarkable, but also has high selectivity, and its performance is impressive.
They produced ATP2A1 with high purity and accurate experimental results.
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