ATP2A1 Protein, ATPase, Ca++ transporting, cardiac muscle, fast twitch 1


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Official Full Name ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Background This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms.
Synonyms ATP2A1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; ATP2A; sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; calcium pump 1; SR Ca(2+)-ATPase 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; calcium-transporting ATPase sarcoplasm
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Atp2a1-666M Recombinant Mouse Atp2a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human ATP2A1-10010H Recombinant Human ATP2A1, His-tagged E.coli His
    Human ATP2A1-2944H Recombinant Human ATP2A1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ATP2A1-969H Recombinant Human ATP2A1 protein, GST-tagged Wheat Germ GST
    Mouse ATP2A1-2120M Recombinant Mouse ATP2A1 Protein Mammalian Cell His
    Chicken ATP2A1-7068C Recombinant Chicken ATP2A1 Mammalian Cell His
    Zebrafish ATP2A1-1616Z Recombinant Zebrafish ATP2A1 Mammalian Cell His

    ATP2A1 involved in several pathways and played different roles in them. We selected most pathways ATP2A1 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway SLC25A5; NOS2B; CAMK4; ADRB3A; P2RX5; HTR2CL1; CACNA1H; P2RX3A; SPHK1; CAMK2B1
    cGMP-PKG signaling pathway ATP2B1; MYH7; INSR; NFATC1; MEF2A; NFATC3; VASP; INS; CREB5; PDE3A
    Pancreatic secretion ATP1B2; CLCA2; RYR2; TRPC1; PLCB2; RAB11A; RAB27B; PLCB4; PLCB1; PLA2G10
    Alzheimers disease NDUFB10; SDHB; GRIN2A; NDUFA1; PSENEN; COX6B1; HSD17B10; COX8A; NDUFS3; NOS1

    ATP2A1 has several biochemical functions, for example, ATP binding, calcium ion binding, calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2A1 itself. We selected most functions ATP2A1 had, and list some proteins which have the same functions with ATP2A1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ABCC8; CPS1; KIF18A; TAE1; CMPK2; NPR1A; C10orf2; TTK; NRBP1; STK25
    calcium ion binding PCDH2AA3; LDLRB; MMP28; EFHB; BGLAP; S100A8; MCTP1; PCDHB11; SPNA2; DOC2D
    calcium-transporting ATPase activity ATP2B1B; ATP2A1L; ATP2A3; ATP2B3A; ATP2C1; ATP2A1; ATP2B1A; ATP2A2A; ATP2B4; ATP2B2
    protein binding CRY1A; P4HA3; CREB3L1; TBX18; CBR2; CHMP2A; ARIH1; RWDD2B; STOM; PNMA2
    protein homodimerization activity FGFR1; VPS4B; UPK1A; VPS24; OXA1L; PTPRE; TDG; LRP4; XDH; TFAP2E

    ATP2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2A1.

    TNFRSF1B; TULP3; RNF167; APPL1; 15-deoxy-delta(12,14

    Asahi, M; Kurzydlowski, K; et al. Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs). JOURNAL OF BIOLOGICAL CHEMISTRY 277:26725-26728(2002).
    Ji, Y; Loukianov, E; et al. SERCA1a can functionally substitute for SERCA2a in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 276:H89-H97(1999).

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