ATP2A3
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Official Full Name
ATPase, Ca++ transporting, ubiquitous
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Overview
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
ATP2A3; ATPase, Ca++ transporting, ubiquitous; sarcoplasmic/endoplasmic reticulum calcium ATPase 3; SERCA3; calcium pump 3; SR Ca(2+)-ATPase 3; adenosine triphosphatase, calcium; calcium-translocating P-type ATPase; ATPase, Ca(2+)-transporting, ubiquitous;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ATP2A3 involved in several pathways and played different roles in them. We selected most pathways ATP2A3 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | TACR3;TMEM8C;BDKRB2;PLCB1;GRIN1A;P2RX3B;P2RX3;PDE1A;MYLK |
| cGMP-PKG signaling pathway | BAD;NPR1;PIK3CG;Adcy4;GUCY1B3;ATP1A1;MAP2K1;IRS2;AKT1 |
| Pancreatic secretion | ATP1A1;PLA2G12A;GNAS;RAB8A;Car2;ITPR3;SLC4A4;RYR2;CTRL |
| Alzheimers disease | CDK5R1;NDUFB7;IL1B;NDUFB3;CAPN1;ATP5O;COX7A2L;UQCRB;ATP5J |
ATP2A3 has several biochemical functions, for example, ATP binding, calcium-transporting ATPase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2A3 itself. We selected most functions ATP2A3 had, and list some proteins which have the same functions with ATP2A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACTR1;ABL1;ZNF143B;EGFRA;MYHZ1.1;RIPK1L;CCT5;CKB;MAP2K2A |
| calcium-transporting ATPase activity | ATP2B3A;ATP2C1;ATP2B2;ATP2C2;ATP2A2;ATP2A3;ATP2A2A;ATP2B1;ATP2A1L |
| metal ion binding | TRIM108;ZBTB17;DZIP1L;MGAT5B;BCL6A;PPARG;RNF121;ZKSCAN3;SDHD |
ATP2A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2A3.
NCK1; HLA-A; BRF2; WRAP73; 15-deoxy-delta(12,14; env; ERBB2; CFTR; ATF2; HDAC11
- Q&As
- Reviews
Q&As (6)
Ask a questionMutations in the recombinant ATP2A3 protein may lead to abnormal changes in its intracellular localization and function, thereby affecting the normal function of cardiomyocytes.
Certain drugs can affect the function of ATP2A3 recombinant protein, such as calcium modulators and cardiovascular drugs. These drugs may affect the intracellular calcium balance and the normal function of the cardiovascular system.
Yes, the expression and function of ATP2A3 recombinant protein in the heart are regulated by complex regulatory mechanisms, including endogenous signaling pathways and regulation of the cardiovascular system.
ATP2A3 recombinant protein is mainly expressed in muscle tissue, heart, kidney and other tissues and organs in the human body.
Yes, mutations in ATP2A3 recombinant protein may be associated with certain cardiovascular diseases (such as myocardial infarction, heart failure, etc.).
The main role of ATP2A3 recombinant protein in the heart is to regulate the intracellular calcium balance of muscle cells and participate in the regulation of myocardial contraction and relaxation.
Customer Reviews (3)
Write a reviewThe green production process of ATP2A3 is very environmentally friendly. From the selection of raw materials to the production process, it reflects the concept of green production, without any negative impact on the environment.
Its repeatability can be said to be unparalleled, and the consistent results in every experiment or application is an important manifestation of its superior quality.
ATP2A3 has a short half-life and high clearance, making it more advantageous in emergency situations where a rapid therapeutic effect is required.
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