|Official Full Name||ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1|
|Background||This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.|
|Synonyms||ATP6V1B1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1; ATP6B1, vacuolar proton pump 3 , VPP3; V-type proton ATPase subunit B, kidney isoform; Renal tubular acidosis with deafness; RTA1B; VATB; Vma2; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 1; kidney isoform; V type proton ATPase subunit B, kidney isoform; Vpp 3; Vpp3; Atp6b1; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 1; ATPase, H+ transporting, V1 subunit B, isoform 1; Endomembrane proton pump 58 kDa subunit; H(+) transporting two sector ATPase 58kD subunit; H+ ATPase beta 1 subunit; Lysosomal 56/58kDa; MGC32642; V type proton ATPase subunit B kidney isoform; V-ATPase subunit B 1; V-type proton ATPase subunit B; Vacuolar proton pump 3; Vacuolar proton pump subunit 3; Vacuolar proton pump subunit B 1; VATB1_HUMAN; OTTHUMP00000160125; OTTHUMP00000204311; V-ATPase B1 subunit; H+-ATPase beta 1 subunit; vacuolar proton pump, subunit 3; H(+)-transporting two-sector ATPase, 58kD subunit|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ATP6V1B1 involved in several pathways and played different roles in them. We selected most pathways ATP6V1B1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Oxidative phosphorylation||NDUFS8; ATP5G3B; PPA2; NDUFB8; ATP6V0A4; ATP6V0C; ATP5H; ATP6V1F; NDUFS4; ATP5S|
|Metabolic pathways||ADH4; TYRP1B; aLA; B3GALT4; DNMT3; NAMPTB; DHRS3; DTYMK; MVK; MDH1AA|
|Phagosome||TUBB1; CD14; MSR1; ATP6V1F; HLA-DRB3; CD209C; ITGA5; MHC2DEB; CD209B; TUBB2B|
|Synaptic vesicle cycle||RAB3A; SLC17A6; UNC13C; STX2; ATP6V1C2; STX3; DNM3; ATP6V1A; ATP6V1B1; ATP6V0B|
|Collecting duct acid secretion||ATP6V1E1; ATP6V0A4; ATP4B; ATP6V1E2; ATP6V1C1; ATP6V0D2; ATP6V1B1; SLC12A7; ATP6V0E; ATP6V1B2|
|Vibrio cholerae infection||PRKACA; ATP6V0D2; ATP6V1B2; ATP6V0A1; ATP6V1E2; ATP6V1F; ATP6V1B1; ATP6V1G2; KDELR3; PRKACB|
|Epithelial cell signaling in Helicobacter pylori infection||PAK1; ADAM17; ATP6V1E2; TCIRG1; ATP6V1G2; ATP6V1B2; ATP6V1B1; IKBKG; IL-8; ATP6V0D2|
|Rheumatoid arthritis||ATP6V1E2; IL15; TEK; ATP6V0E; ATP6V0A2; ATP6V0D1; HLA-DRB4; IL1B; TNFSF13B; ATP6V0E1|
ATP6V1B1 has several biochemical functions, for example, ATP binding, hydrogen ion transmembrane transporter activity, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1B1 itself. We selected most functions ATP6V1B1 had, and list some proteins which have the same functions with ATP6V1B1. You can find most of the proteins on our site.
|ATP binding||PSMC1; PRPF4BB; BMPR1BA; NETO2; MTHFD1; STK24A; EPB42; SPS2; OAS2; NAV2|
|hydrogen ion transmembrane transporter activity||ATP6V0E; SLC11A2; ATP5G3; ATP6V1C1A; ATP6V0E2; SLC36A1; ATP6V0A1B; ATP6V0A2B; SLC46A1; SLC36A3|
|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances||ATP6V1G2; ATP6V1AA; ATP6V1BA; ATP6V1B1|
|protein complex binding||RIPK3; FBN1; CRTAP; CPD; BRK1; MYC; CFLAR; BAG3; PAFAH1B1; ST13|
ATP6V1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1B1.
SUV39H1; KDM1A; ATP6V0A1