atp6v1e1
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  • Official Full Name
  • ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
  • Background
  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome.
  • Synonyms
  • ATP6V1E1; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1; ATP6E, ATP6V1E, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 31kD , ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1; V-type proton ATPase subunit E 1; ATP6E2; P31; Vma4; ATP6E; ATP6V1E; V ATPase 31 kDa subunit; Vacuolar proton pump subunit E 1; OTTHUMP00000065606; OTTHUMP00000196213; OTTHUMP00000214152; OTTHUMP00000214153; V-ATPase, subunit E; V-ATPase subunit E 1; V-ATPase 31 kDa subunit; H+-transporting ATP synthase chain E, vacuolar; H(+)-transporting two-sector ATPase, 31kDa subunit
Cat.#:ATP6V1E1-386HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP6V1E1, T7-tagged
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Cat.#:ATP6V1E1-10046HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP6V1E1, GST-tagged
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Cat.#:ATP6V1E1-1006HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ATP6V1E1 protein, GST-tagged
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Cat.#:ATP6V1E1-2164MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ATP6V1E1 Protein
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Cat.#:ATP6V1E1-893RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ATP6V1E1 Protein
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Cat.#:ATP6V1E1-328CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ATP6V1E1 Protein, His-tagged
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Cat.#:ATP6V1E1-1393CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ATP6V1E1
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Cat.#:ATP6V1E1-8580HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ATP6V1E1 293 Cell Lysate
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Involved Pathway

ATP6V1E1 involved in several pathways and played different roles in them. We selected most pathways ATP6V1E1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
SDHDB; SDHA; COX7B2; ATP6V1H; UQCRH; ATP6AP1B; ATP5G1; NDUFA4L; COX5B2; ATP6V1AA
Metabolic pathways
HYAL3; GUK1A; SC4MOL; MOGAT3; COQ2; PFKM; HSD3B2; PPAP2D; PLA2G10; GBGT1
Phagosome
FCGR3B; NOS1; HBL4; MHC1UXA2; TUBB; SEC61G; TUBA3B; TAP1; CTSL1B; TUBB2B
Synaptic vesicle cycle
SLC17A6; STX3; SLC17A7; UNC13A; SNAP25; SLC18A2; ATP6V1D; ATP6V1E2; ATP6V1H; ATP6V0A2
Collecting duct acid secretion
TCIRG1; CLCNKB; ATP6V0E1; SLC12A7; ATP6V1E2; ATP6V0A1; ATP6V0C; ATP6V0D2; ATP6V1C1; ATP6V1G1
Vibrio cholerae infection
TJP1; ATP6V1C1; ATP6V0C; PRKACA; ATP6V0B; KDELR2; TJP2; ATP6V0A4; ATP6V1H; ATP6V1G2
Epithelial cell signaling in Helicobacter pylori infection
RAC1; CCL5; TJP1; NFKBIA; SRC; ATP6V1D; PLCG1; MAPK8; PLCG2; CDC42
Rheumatoid arthritis
ITGB2L; CCL20; ATP6V0E; TGFB2; TGFB1; ATP6V1A; ATP6AP1; CXCL12; IL18; ATP6V0E2

Protein Function

ATP6V1E1 has several biochemical functions, for example, ATPase binding, hydrogen-exporting ATPase activity, phosphorylative mechanism, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1E1 itself. We selected most functions ATP6V1E1 had, and list some proteins which have the same functions with ATP6V1E1. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein SNX10; LCK; ATP6V0A1B; UBXN1; DNAJB1; TCIRG1; FXYD3; DERL1; ATP1B2; DNAJC10
Function hydrogen-exporting ATPase activity, phosphorylative mechanism
Related Protein ATP6V1C1; ATP6V1G1; ATP6V0D1; ATP6V1E1; ATP6V1G3; ATP6V1C2; ATP6V1E2
Function protein binding
Related Protein SLC6A4; TBPL1; APITD1; CCNL1; C22orf23; ALOX5AP; DTX2; CA2; SPRR3; RPS6KA2
Function proton-transporting ATPase activity, rotational mechanism
Related Protein ATP6V1E1; ATP6V0A1; ATP6V1E1B; ATP6V1A; ATP6V1AA; ATP6V1C1; ATP6V0E2; ATP5B; ATPV0E2; ATP6V0E

Interacting Protein

ATP6V1E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1E1.
DEDD; ATP6V1G1; ATP6V1G2; XRCC6; MESDC2; pyrH; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; ATP6V1A; Rmdn3; Chmp4b; CHMP4B; GOLT1B

ATP6V1E1 Related Articles

Yang, LS; Xu, XE; et al. iTRAQ-based quantitative proteomic analysis for identification of oligodendroglioma biomarkers related with loss of heterozygosity on chromosomal arm 1p. JOURNAL OF PROTEOMICS 77:480-491(2012).
Knijnenburg, J; van Bever, Y; et al. A 600 kb triplication in the cat eye syndrome critical region causes anorectal, renal and preauricular anomalies in a three-generation family. EUROPEAN JOURNAL OF HUMAN GENETICS 20:986-989(2012).