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ATP6V1G3

Official Full Name

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
Overview

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.
Synonyms

ATP6V1G3; ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3; ATPase, H+ transporting, lysosomal 13kD, V1 subunit G isoform 3 , ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 3; V-type proton ATPase subunit G 3; ATP6G3; Vma10; MGC119810; MGC119813; MGC130213; MGC130214; V ATPase 13 kDa subunit 3; V ATPase subunit G 3; Vacuolar proton pump subunit G 3; V-ATPase G3 subunit; V-ATPase G subunit 3; V-ATPase subunit G 3; V-ATPase 13 kDa subunit 3; vacuolar proton pump G subunit 3; vacuolar proton pump, subunit G3; vacuolar ATP synthase subunit G 3; ATPase, H+ transporting, lysosomal (vacuolar proton pump) subunit G3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ATP6V1G3-1011H	Recombinant Human ATP6V1G3 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ATP6V1G3-8574HCL	Recombinant Human ATP6V1G3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ATP6V1G3-8575HCL	Recombinant Human ATP6V1G3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ATP6V1G3-1333HF	Recombinant Full Length Human ATP6V1G3 Protein, GST-tagged	In Vitro Cell Free System	GST	118 amino acids	Inquiry
Mouse	ATP6V1G3-2169M	Recombinant Mouse ATP6V1G3 Protein	Mammalian Cell	His		Inquiry
Mouse	Atp6v1g3-1777M	Recombinant Mouse Atp6v1g3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	ATP6V1G3-883M-B	Recombinant Mouse ATP6V1G3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	ATP6V1G3-883M	Recombinant Mouse ATP6V1G3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ATP6V1G3 involved in several pathways and played different roles in them. We selected most pathways ATP6V1G3 participated on our site, such as Collecting duct acid secretion, Epithelial cell signaling in Helicobacter pylori infection, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1G3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Collecting duct acid secretion	ATP6V1G2;ATP6V1E1;ATP6V0C;ATP6V1E2;ATP6V0D1;ATP6V1F;ATP6V1A;SLC4A1;ATP6V1G1
Epithelial cell signaling in Helicobacter pylori infection	ATP6V1F;NOD1;ATP6V1A;ATP6V0A1;CDC42;MAP3K14;ATP6V0A4;NFKB1;ATP6V0E1
Immune System	WASF3;HAVCR2;NLRP4C;CRCP;CLEC2D;FBXO3;PJA2;LGALS9;FAM49BA
Insulin receptor recycling	ATP6V1G3;TCIRG1
Ion channel transport	ATP2C2;HTR3C;SGK2;ANO5;TRPC6A;ANO4;CLCN2;ANO8;ASPH
Iron uptake and transport	FLVCR1;SLC46A1;TFA;SLC22A17;TCIRG1;FTH1B;MFSD7B;LCN2;ATP6V1G3
Metabolic pathways	CBR2;ALDH5A1;MT-ATP6;MAOA;PTS;DBH;GRHPRA;B3GNT3;HGSNAT
Oxidative phosphorylation	NDUFB7;ATP12A;ATP6V1H;COX7B2;NDUFS7;ATP6V0C;ATP5G1;ATP6V1C1;NDUFA4L

ATP6V1G3 has several biochemical functions, for example, ATPase binding, hydrogen-exporting ATPase activity, phosphorylative mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1G3 itself. We selected most functions ATP6V1G3 had, and list some proteins which have the same functions with ATP6V1G3. You can find most of the proteins on our site.

Function	Related Protein
ATPase binding	DRD1;ATPIF1B;NUFIP1;PEX19;Ar;PTPN3;ATPIF1A;PIH1D1;ATPIF1
hydrogen-exporting ATPase activity, phosphorylative mechanism	ATP6V1G3;ATP6V0D1;ATP6V1E2;ATP6V1C2;ATP6V1E1;ATP6V1G1;ATP6V1C1

ATP6V1G3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1G3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1G3.