AXIN1 Protein, axin 1

AXIN1

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AXIN1

Official Full Name axin 1
Background Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Synonyms AXIN1; axin 1; axin-1; PPP1R49; protein phosphatase 1; regulatory subunit 49; AI316800; AXIN; Axin 1; Axin-1; axin1; AXIN1_HUMAN; Axis inhibition protein 1; Axis Inhibitor 1; hAxin; Kb; Ki; kinky; knobbly; axis inhibition protein 1; protein phosphatase 1, regulatory subunit 49; AXIN
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Axin1-684M Recombinant Mouse Axin1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human AXIN1-10084H Recombinant Human AXIN1, His-tagged E.coli His
    Human AXIN1-1047H Recombinant Human AXIN1 protein, GST-tagged Wheat Germ GST
    Human AXIN1-105H Recombinant Human AXIN1, GST-tagged Wheat Germ GST
    Human AXIN1-106H Recombinant Human AXIN1, MYC/DDK-tagged HEK293 Myc/DDK
    Human AXIN1-26564TH Recombinant Human AXIN1, His-tagged E.coli His
    Human AXIN1-388H Recombinant Human AXIN1 Protein, His-tagged E.coli His
    Human AXIN1-665H Recombinant Human AXIN1 Mammalian Cell His
    Mouse Axin1-3793M Recombinant Mouse Axin1, His-tagged E.Coli or Yeast His
    Mouse Axin1-389M Recombinant Mouse Axin1 Protein, His-tagged E.coli His
    Rat Axin1-390R Recombinant Rat Axin1 Protein, His-tagged E.coli His
    Rat AXIN1-909R Recombinant Rat AXIN1 Protein Mammalian Cell His
    Chicken AXIN1-6504C Recombinant Chicken AXIN1 Mammalian Cell His
    Zebrafish AXIN1-9053Z Recombinant Zebrafish AXIN1 Mammalian Cell His

    AXIN1 involved in several pathways and played different roles in them. We selected most pathways AXIN1 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with AXIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway NKD1; WNT3; MAP3K7; SMAD4; FZD3A; VANGL2; NFATC1; WNT9B; LRP6; PRKCG
    Hippo signaling pathway PPP2R2D; WNT16; PARD6B; PPP2R2A; BMPR2; GLI2; WTIP; SMAD4; Fzd4; YWHAG
    Signaling pathways regulating pluripotency of stem cells PIK3R3; PIK3R1; SMAD3; WNT9A; JARID2; KRAS; ESRRB; PIK3R2; MYF5; PIK3CD
    Pathways in cancer WNT16; HHIP; Flt3l; WNT11; GNG8; TPM3; WNT8B; PAX8; FGFR1; MAPK9
    Colorectal cancer PIK3CA; MSH6; APC2; ARAF; RAC2; DCC; MLH1; SMAD3; GSK3B; RHOA
    Endometrial cancer GSK3B; GRB2; HRAS; MAP2K2; BAD; PIK3R3; ILK; APC2; PIK3R5; PDPK1
    Basal cell carcinoma GSK3B; GLI1; WNT5A; WNT3; DVL3; FZD7; TP53; SMO; SETD6; WNT5B

    AXIN1 has several biochemical functions, for example, GTPase activator activity, I-SMAD binding, R-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AXIN1 itself. We selected most functions AXIN1 had, and list some proteins which have the same functions with AXIN1. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity RABEP2; TBC1D2B; TBC1D14; RANBP1; AGAP1; SIPA1L1; SRGAP2; AGAP5; ARHGAP42; ANKRD27
    I-SMAD binding AXIN2; SMAD7; SMAD1; TGFBR1; TGFB1I1; SMURF1; SMAD2; SMAD6; CTNNB1; AXIN1
    R-SMAD binding MYOCD; JUN; ZC3H3; AXIN1; SMAD4; FOS; C18orf1; PARP1; CTNNB1; SMURF1
    SMAD binding SKI; ACVRL1; ACVR1B; BMP2; EP300; ACVR1; TCF12; SMURF2; CTNNB1; HMGA2
    armadillo repeat domain binding AXIN2; CTNNBIP1; TCF7L2; AXIN1; CALCOCO1; CNOT1; STRN4; CHD8; LEF1; STRN
    beta-catenin binding RORA; APC2; DACT3; ASH2L; PTPRK; PTPRJ; VCL; NUMB; GLI3; CTNNA1
    enzyme binding P4HB; SNX12; IQCB1; KPNB1; PEBP1; C6orf211; USP22; PHKG2; HLCS; CPSF1
    identical protein binding G6PDX; SYP; PIK3AP1; DAPK3; GOT2B; RUNX1T1; ALS2CL; CRYBB2; HOMER1; PRMT1
    p53 binding NTRK3; RNF20; SMARCA4; ZFP346; DAXX; TRP63; DUSP26; ZNF385A; SETD8; BRD4
    protein C-terminus binding CITED1; KPNA3; PPP2CB; PPP2CA; MAP2K1; PEX1; PDZD3; YWHAB; TRP53; ERBB2
    protein binding HTR1B; DCUN1D1; TMEM43; GPANK1; PSPC1; ARHGEF15; USP44; UBXN4; EXOSC3; SCUBE3
    protein complex scaffold DLG1; C9orf142; TELO2; CHCHD3; GNB2L1; MAGI1B; CAV2; DISC1; PKP2; WWC2
    protein homodimerization activity CIDEA; CLIC6; GIMAP7; ACCS; MCL1B; NOS2; HSP90AA1; GNB2L1; MAP3K5; LMLN
    protein kinase binding DNM1; CLTC; RHOD; SHC1; NGFRAP1; SKI; SPAG16; CEP152; RNF138; VRK1
    protein self-association TP53; TRP53; NKX3-1; AGA; SHANK3; ZNF496; TTN; ACVR2A; S100A7A; ACHE
    receptor signaling complex scaffold activity DEDD2; CARD10; CD3G; SPAG9A; LDLRAP1; SPAG9; GRIP1; GRIP2A; LRRK2; NCK2
    signal transducer activity TAAR19P; ADRA2DB; GNA12; TAAR12A; FPR-RS6; GNAIA; TMED4; TAS2R144; TAAR8A; MAPKAPK2B
    ubiquitin protein ligase binding UBE2B; DTX1; USP13; RNF40; UBE2G1B; FAF2; UBE2W; CUL1; UBE2G1; UBE2J1

    AXIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AXIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AXIN1.

    GSK3B

    Valenti, F; Ibetti, J; et al. The Increase in Maternal Expression of axin1 and axin2 Contribute to the Zebrafish Mutant Ichabod Ventralized Phenotype. JOURNAL OF CELLULAR BIOCHEMISTRY 116:418-430(2015).
    Siwek, M; Slawinska, A; et al. A quantitative trait locus for a primary antibody response to keyhole limpet hemocyanin on chicken chromosome 14-Confirmation and candidate gene approach. POULTRY SCIENCE 89:1850-1857(2010).

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