| Description : |
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
91.5 kDa |
| AA Sequence : |
MNIQEQGFPLDLGASFTEDAPRPPV PGEEGELVSTDPRPASYSFCSGKGV GIKGETSTATPRRSDLDLGYEPEGS ASPTPPYLKWAESLHSLLDDQDGIS LFRTFLKQEGCADLLDFWFACTGFR KLEPCDSNEEKRLKLARAIYRKYIL DNNGIVSRQTKPATKSFIKGCIMKQ LIDPAMFDQAQTEIQATMEENTYPS FLKSDIYLEYTRTGSESPKVCSDQS SGSGTGKGISGYLPTLNEDEEWKCD QDMDEDDGRDAAPPGRLPQKLLLET AAPRVSSSRRYSEGREFRYGSWREP VNPYYVNAGYALAPATSANDSEQQS LSSDADTLSLTDSSVDGIPPYRIRK QHRREMQESVQVNGRVPLPHIPRTY RVPKEVRVEPQKFAEELIHRLEAVQ RTREAEEKLEERLKRVRMEEEGEDG DPSSGPPGPCHKLPPAPAWHHFPPR CVDMGCAGLRDAHEENPESILDEHV QRVLRTPGRQSPGPGHRSPDSGHVA KMPVALGGAASGHGKHVPKSGAKLD AAGLHHHRHVHHHVHHSTARPKEQV EAEATRRAQSSFAWGLEPHSHGARS RGYSESVGAAPNASDGLAHSGKVGV ACKRNAKKAESGKSASTEVPGASED AEKNQKIMQWIIEGEKEISRHRRTG HGSSGTRKPQPHENSRPLSLEHPWA GPQLRTSVQPSHLFIQDPTMPPHPA PNPLTQLEEARRRLEEEEKRASRAP SKQRTRSQRKVGGGSAQPCDSIVVA YYFCGEPIPYRTLVRGRAVTLGQFK ELLTKKGSYRYYFKKVSDEFDCGVV FEEVREDEAVLPVFEEKIIGKVEKV DTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
