| Species : |
Human |
| Source : |
Sf9 Cells |
| Tag : |
GST |
| Description : |
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. |
| Molecular Mass : |
~135 kDa |
| Purity : |
≥75% |
| Usage : |
Research Use Only |
| Storage : |
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration : |
0.05 µg/µl |
| Storage Buffer : |
Recombinant protein stored in 50mM Tris-HCl, pH 7.5,50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT,0.1mM PMSF, 25% glycerol. |
| Shipping : |
Shipped with ice pack. |
