ADORA1
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Official Full Name
adenosine A1 receptor
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Overview
inhibits adenylyl cyclase activity; plays a role in regulation of arterial pressure, heart rate, and sodium excretion [RGD, Feb 2006] -
Synonyms
ADORA1; adenosine A1 receptor; adenosine receptor A1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Cavia porcellus (Guinea pig)
- Chicken
- Gallus gallus (Chicken)
- Guinea pig
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- In vitro E. coli expression system
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Flag
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ADORA1-9433H | Recombinant Human ADORA1, GST-tagged | E.coli | GST | 184-243a.a. | |
Human | ADORA1-9006HCL | Recombinant Human ADORA1 293 Cell Lysate | HEK293 | N/A | ||
Human | ADORA1-1052H | Recombinant Human ADORA1 Full Length Transmembrane protein, His-tagged | In vitro E. coli expression system | His | 1-326aa | |
Human | ADORA1-1150HFL | Recombinant Human ADORA1 protein, His&Flag-tagged | HEK293 | His&Flag | 1-326 aa | |
Mouse | ADORA1-1370M | Recombinant Mouse ADORA1 Protein | Mammalian Cell | His | ||
Mouse | ADORA1-355M | Recombinant Mouse ADORA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ADORA1-355M-B | Recombinant Mouse ADORA1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ADORA1-532R | Recombinant Rat ADORA1 Protein | Mammalian Cell | His | ||
Rat | ADORA1-188R-B | Recombinant Rat ADORA1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ADORA1-188R | Recombinant Rat ADORA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Bos taurus (Bovine) | RFL-21203BF | Recombinant Full Length Bovine Adenosine Receptor A1(Adora1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-326) | |
Canis lupus familiaris (Dog) (Canis familiaris) | RFL-8763CF | Recombinant Full Length Dog Adenosine Receptor A1(Adora1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-326) | |
Cavia porcellus (Guinea pig) | RFL-21510CF | Recombinant Full Length Guinea Pig Adenosine Receptor A1(Adora1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-326) | |
Gallus gallus (Chicken) | RFL-3226GF | Recombinant Full Length Chicken Adenosine Receptor A1(Adora1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-324) | |
Guinea pig | Adora1-3159C | Recombinant Cavia porcellus (Guinea pig) Adora1, His-tagged | E.Coli or Yeast | His | 326 | |
Homo sapiens (Human) | RFL-12092HF | Recombinant Full Length Human Adenosine Receptor A1(Adora1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-326aa) | |
Mus musculus (Mouse) | RFL25509MF | Recombinant Full Length Mouse Adenosine Receptor A1(Adora1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-326) | |
Oryctolagus cuniculus (Rabbit) | RFL-16138OF | Recombinant Full Length Rabbit Adenosine Receptor A1(Adora1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-328) | |
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) | RFL3483PF | Recombinant Full Length Pongo Abelii Adenosine Receptor A1(Adora1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-326) | |
Rattus norvegicus (Rat) | RFL-995RF | Recombinant Full Length Rat Adenosine Receptor A1(Adora1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-326) | |
Rhesus Macaque | ADORA1-254R | Recombinant Rhesus monkey ADORA1 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | ADORA1-82R | Recombinant Rhesus Macaque ADORA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | ADORA1-82R-B | Recombinant Rhesus Macaque ADORA1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | ADORA1-6958Z | Recombinant Zebrafish ADORA1 | Mammalian Cell | His | ||
Chicken | ADORA1-5889C | Recombinant Chicken ADORA1 | Mammalian Cell | His | ||
Chicken | ADORA1-3160C | Recombinant Chicken ADORA1, His-tagged | E.Coli or Yeast | His | 324 |
- Involved Pathway
- Protein Function
- Interacting Protein
- ADORA1 Related Research Area
ADORA1 involved in several pathways and played different roles in them. We selected most pathways ADORA1 participated on our site, such as Adenosine P1 receptors, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADORA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Adenosine P1 receptors | ADORA2A;ADORA3;ADORA2B;ADORA1 |
Class A/1 (Rhodopsin-like receptors) | CHRM4;NMBB;PYY;LTB4R;OPN4A;ANXA1;OXGR1A.3;TAAR1;GPR77 |
G alpha (i) signalling events | RGS20;FPR-RS4;ANXA1A;PTGDR2;RGS1;FPR-RS3;PYYA;APPA;CCR3 |
GPCR downstream signaling | MLN;CXCR6;GPR17;APPB;ADORA2A;CALCB;PTHLH;CCR7;GPR18 |
GPCR ligand binding | GPR4;OPN1LW1;CCR1;PNOCB;S1PR1;CALCB;CRHB;TAC3;PROK1 |
GPCRs, Class A Rhodopsin-like | GPR45;FPR-RS4;GPR20;GPR85;SSTR1;GPR3;GPR77;NMUR1;SSTR4 |
Neuroactive ligand-receptor interaction | PTGER4;HRH1;PTGER2;HRH2;TAAR14F;GALR1;HTR1AA;PTGER4B;GABRR3A |
ADORA1 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding, G-protein coupled adenosine receptor activity, G-protein coupled receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADORA1 itself. We selected most functions ADORA1 had, and list some proteins which have the same functions with ADORA1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
G-protein beta/gamma-subunit complex binding | GNAT3;PIK3R5;GNAQ;GNAZ;CETN4;GNAS;GNAIA;GNAO1;GNA11 |
G-protein coupled adenosine receptor activity | ADORA2AA;ADORA2AB;ADORA2B;ADORA1;ADORA2A;P2RY12;ADORA3 |
G-protein coupled receptor binding | ITGB4;INSL3;USP20;UCN3L;NPB;GNA12A;SFTPB;PSAP;GNA15.4 |
heterotrimeric G-protein binding | CETN1;ADORA1;CETN4;CETN2;ADRA2A |
phospholipase C activity | PLCH2;PLCB3;PLCL1;PDIA3;PLCG2;ADORA1;PLCB2;PLCG1;PLCB4 |
protein binding | ERO1LB;EIF4EBP1;TRIAP1;BNIP3L;MYL6B;SRSF3;PTRH2;RAB4B;CLCN1 |
protein heterodimerization activity | RRAGA;HIST1H2BP;MYOG;APITD1;SYCP2;SUPT3H;DMRT1;CENPW;NPM1 |
purine nucleoside binding | C6orf130;ADA;ADORA1 |
ADORA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADORA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADORA1.
ADORA2A; dpcpx; SNF8
- Q&As
- Reviews
Q&As (12)
Ask a questionA variety of techniques are used to study ADORA1 proteins, including molecular biology, biochemistry, and pharmacology. Molecular biology techniques can be used to clone and express ADORA1 receptors for further study. Biochemical assays can be used to measure ADORA1 activity, such as cAMP production or intracellular calcium signaling. Pharmacological assays can be used to test the efficacy of drugs that target ADORA1, both in vitro and in vivo.
While mutations in the ADORA1 gene have not been specifically implicated in diseases, variations in ADORA1 gene expression and activity have been associated with various pathological conditions. For example, increased ADORA1 expression has been correlated with the development of lung cancer and glioma, while decreased ADORA1 expression has been associated with rheumatoid arthritis and ischemic heart disease.
ADORA1 is involved in sleep regulation by promoting sleep and reducing wakefulness. Specifically, ADORA1 activation promotes slow wave sleep (SWS), which is a deep stage of non-REM sleep characterized by low cortical activity and is thought to be restorative. This effect is likely mediated by ADORA1 activation on neurons in the brain that promote SWS. In addition, caffeine, a non-selective adenosine receptor antagonist, blocks ADORA1 activation and reduces the propensity for SWS, resulting in increased wakefulness.
Yes, ADORA1 is an attractive therapeutic target for several medical conditions. For example, drugs that selectively activate or inhibit ADORA1 could be used to treat inflammatory diseases by modulating immune cell activation and inflammatory signaling. Additionally, targeting ADORA1 could be a useful approach for treating cancers that overexpress this receptor, as inhibiting ADORA1 activation could potentially slow tumor growth and metastasis.
Yes, there are genetic mutations associated with ADORA1 that can affect health. One such mutation is a single nucleotide polymorphism (SNP) in the ADORA1 gene that has been linked to increased susceptibility to autoimmune and inflammatory diseases such as rheumatoid arthritis and psoriasis. Another SNP has been found to be associated with a higher risk of developing Alzheimer's disease. These findings suggest that genetic variations in ADORA1 may impact immune function and neurodegenerative diseases.
ADORA1 interacts with other neurotransmitter systems in the brain by modulating their activity. For example, ADORA1 activation can inhibit the release of glutamate, a major excitatory neurotransmitter, and increase the release of GABA, a major inhibitory neurotransmitter. ADORA1 activation can also modulate the activity of dopamine, serotonin, and acetylcholine neurotransmitter systems, among others. These interactions suggest that ADORA1 plays a role in the complex network of neurotransmitter systems that regulate brain function and behavior.
ADORA1 proteins may have potential as biomarkers for certain disease conditions. For example, ADORA1 expression has been shown to be upregulated in various cancer types, and ADORA1 has been proposed as a potential biomarker for breast cancer prognosis. Additionally, ADORA1 expression has been found to be altered in individuals with major depressive disorder, suggesting that it may have potential as a diagnostic or prognostic biomarker for this condition.
There are several drugs that target ADORA1 proteins. One example is caffeine, which is an adenosine receptor antagonist that binds to and blocks ADORA1 activation. Other drugs that target ADORA1 include the anti-inflammatory agent ibudilast, which has been shown to reduce ADORA1 expression and modulate inflammation in the central nervous system, and the bronchodilator theophylline, which is used to treat asthma and COPD by inhibiting ADORA1 activation.
Dysregulation of ADORA1 signaling has been implicated in a number of pathological conditions. For example, ADORA1 overexpression has been associated with tumor growth and metastasis in certain cancers. In the brain, ADORA1 activation has been linked to the development of epileptic seizures and neuronal degeneration in Huntington's disease. Conversely, ADORA1 deficiency has been associated with insulin resistance and the development of type 2 diabetes.
Yes, ADORA1 has been identified as a potential target for pain relief. Activation of ADORA1 produces anti-nociceptive effects, meaning it can alleviate pain. Several studies have looked at selective ADORA1 agonists for their potential as analgesics. In addition, caffeine has been shown to have an indirect effect on ADORA1, leading to pain relief in certain conditions.
Research on ADORA1 is ongoing in a number of areas, including cancer biology, neuroscience, and immunology. One current area of investigation is the role of ADORA1 in chronic pain, as it has been shown to be upregulated in certain pain conditions. Additionally, ADORA1 is being studied as a potential target for Parkinson's disease, as ADORA1 agonists have been shown to improve motor symptoms in animal models of the disease.
Yes, there can be side effects associated with targeting ADORA1. For example, drugs that activate or block ADORA1 may affect cardiovascular function, including heart rate and blood pressure. Other potential side effects include altered immune system function, sedation, and gastrointestinal effects. As with any drug development, careful evaluation of safety and efficacy must be conducted to determine the potential benefits and drawbacks of targeting ADORA1.
Customer Reviews (4)
Write a reviewthe purity and activity of the protein are impressive and give me confidence in obtaining reproducible and meaningful results.
The extensive technical support provided by the manufacturer has already addressed some of my concerns and I am confident that they will be able to assist me further should I require more information or help.
I am satisfied with the product and the service, and I would recommend it to other researchers who may need a reliable ADORA1 protein source.
Based on its characteristics and qualities, I am confident that the ADORA1 protein will perfectly suit my experimental requirements.
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