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Alox12

  • Official Full Name

    arachidonate 12-lipoxygenase

  • Overview

    Arachidonate 12-lipoxygenase, 12S-type is an enzyme that in humans is encoded by the ALOX12 gene.
  • Synonyms

    ALOX12; arachidonate 12-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; 12S-type; 12 Lox; 12(S) lipoxygenase; 12S LOX; 12S-lipoxygenase; 12S-LOX; Alox 12; Alox12L; Alox15; Arachidonate 12 lipoxygenase 12S type; Arachidonate 12 lipoxygenase; Arachidonate 12 lipoxygenase leukocyte type; Arachidonate 12 lipoxygenase, 12S type; Arachidonate 12 lipoxygenase, leukocyte type; EC1.13.11.31; LOG 12; LOG12; LOX12_HUMAN; Platelet type 12 lipoxygenase; Platelet type lipoxygenase 12; Platelet-type lipoxygenase 12; P-12LO; Alox12p; 9930022G08Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALOX12-269H Recombinant Human ALOX12 Mammalian Cell His
Human ALOX12-01H Recombinant Human ALOX12 Protein E.coli Tag Free
Human ALOX12-2031H Recombinant Human ALOX12 protein, His & T7-tagged E.coli His/T7 Phe352~Cys656 (Accession # P18054)
Human ALOX12-482H Recombinant Human ALOX12 Protein, GST-tagged Wheat Germ GST
Human ALOX12-64HCL Recombinant Human ALOX12 cell lysate N/A
Human ALOX12-2815H Recombinant Human ALOX12 protein, His-tagged E.coli His 111 - 230 aa
Human ALOX12-0560H Recombinant Human ALOX12 Protein (Phe352-Cys656), N-His-tagged E.coli N-His Phe352-Cys656
Human ALOX12-18HF Recombinant Full Length Human ALOX12 Protein In Vitro Cell Free System 663 amino acids
Human ALOX12-2510H Recombinant Human ALOX12 protein, His-tagged E.coli His 1-663aa
Human ALOX12-1478HFL Recombinant Full Length Human ALOX12 Protein, C-Flag-tagged Mammalian cells Flag
Human ALOX12-26002TH Recombinant Human ALOX12 Wheat Germ N/A 663 amino acids
Human ALOX12-1466HF Recombinant Full Length Human ALOX12 Protein, GST-tagged In Vitro Cell Free System GST 663 amino acids
Human ALOX12-2197H Recombinant Human ALOX12 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ALOX12-323H Recombinant Human ALOX12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ALOX12-323H-B Recombinant Human ALOX12 Protein Pre-coupled Magnetic Beads HEK293
Mouse Alox12-584M Recombinant Mouse Arachidonate 12-lipoxygenase, His-tagged Insect Cell His
Mouse Alox12-578M Recombinant Mouse Alox12 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Alox12-104M Recombinant Mouse Alox12 Protein, His-tagged Insect cell His
Mouse Alox12-021M Recombinant mouse Alox12 Protein, His-tagged Insect Cells His 2-664
Zebrafish ALOX12-10019Z Recombinant Zebrafish ALOX12 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Alox12 involved in several pathways and played different roles in them. We selected most pathways Alox12 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Alox12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismCYP2B6;CYP4F22;GPX3;PTGES3;PLA2G12A;CYP1B1;CYP2U1;CYP2P10;ALOX5B.2
Metabolic pathwaysPYGMA;DHRS3B;CYP26C1;ALDH3B1;PDHA2;BDH1;CS;POLR2E;ABP1
Serotonergic synapseCYP2D9;HTR5A;HTR3E;TPH2;GNG12;PTGS1;PLCB3;MAOA;HTR3A
Inflammatory mediator regulation of TRP channelsGNAQ;PLA2G4C;PLCG1;PTGER4;IL1R1;HRH1;PRKCB;CALML5;PIK3R1

Alox12 has several biochemical functions, for example, arachidonate 12-lipoxygenase activity, hepoxilin A3 synthase activity, hepoxilin-epoxide hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Alox12 itself. We selected most functions Alox12 had, and list some proteins which have the same functions with Alox12. You can find most of the proteins on our site.

Function Related Protein
arachidonate 12-lipoxygenase activityALOX12;ALOX15;ALOX12E;ALOX12B
hepoxilin A3 synthase activityALOX15;ALOX12
hepoxilin-epoxide hydrolase activityALOX12;ALOX15
iron ion bindingCYP2AD6;CYP7A1A;SLC11A2;PTGIS;OGFOD2;LCN2;CYP3C4;CYP11A1;CYP2C38
linoleate 13S-lipoxygenase activityALOX8;ALOX12;ALOX15B
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenBCO2;P4HA1B;P4HA2;P4HA1;ALOX5A;P4HA1A;ALOX12;ADOB;ALOX12B
protein bindingING4;BBC3;ARPC5;P4HB;SET;ZNF821;DNAJA1;KRT79;CEP76

Alox12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Alox12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Alox12.

KRT5; LMNA; PLA2G2A; ITGB4; TRIB1

  • Q&As
  • Reviews

Q&As (13)

Ask a question
What role does ALOX12 play in hepatitis? 12/27/2022

It is involved in the pathological process of virus-induced hepatitis, which may be related to virus clearance and liver disease recovery.

What signaling pathways are involved in ALOX12? 08/22/2022

This is associated with some signaling pathways, such as PI3K/AKT pathway and MAPK pathway.

How does ALOX12 play in obesity? 07/31/2022

ALOX12 is involved in several biological processes associated with obesity, such as adipocyte differentiation, glucose and lipid metabolism.

How does ALOX12 play in neurodegenerative diseases? 12/10/2021

ALOX12 is involved in the occurrence and development of a variety of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.

What role does ALOX12 play in diabetes? 11/24/2021

ALOX12 is involved in endothelial cell function impairment and is associated with diabetic complications.

What is the protein structure of ALOX12? 11/19/2021

This is a membrane binding protein with a core membrane binding domain and an extramembrane catalytic domain.

What is the catalytic mechanism of ALOX12? 04/07/2021

The oxidizes linolenic acid to produce 12S-LOX and 15S-LOX metabolites by oxygenation.

In what metabolic pathways does ALOX12 play a role? 12/08/2020

This protein is mainly involved in the metabolic pathway of linolenic acid, catalyzing the synthesis of 12S-LOX and 15S-LOX metabolites.

What role does ALOX12 play in cells? 07/23/2020

ALOX12 catalyzes linolenic acid to produce 12S-LOX and 15S-LOX metabolites, which have biological activities, including participating in inflammatory responses, regulating platelet activation, and regulating T cell function.

In which tissues is ALOX12 expressed? 07/15/2020

It is expressed in a variety of tissues in the human body, such as the skin, heart, lungs, liver, kidneys, intestines, and nervous system.

What are the variants of the ALOX12 gene? 05/30/2020

The human ALOX12 gene has a variety of variants, including SNP and InDel, that can lead to its dysfunction or increased risk.

Which role of ALOX12 in myocardial infarction? 03/26/2020

ALOX12 is involved in the process of myocardial cell damage after myocardial infarction, which may be related to myocardial regeneration and repair.

What diseases is ALOX12 associated with? 02/16/2020

ALOX12 is believed to be associated with a variety of diseases, such as cancer, inflammation, neurodegenerative diseases, cardiovascular disease, and more.

Customer Reviews (4)

Write a review
Reviews
11/03/2021

    It has good efficacy and high safety as an immunotherapy drug.

    03/31/2020

      ALOX12 has a good inhibitory effect on cell proliferation and survival.

      09/14/2019

        There is no interaction or influence with other drugs.

        01/27/2019

          Functionally enhanced or altered by protein modification techniques.

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