| Official Full Name | arachidonate 12-lipoxygenase |
| Background | Arachidonate 12-lipoxygenase, 12S-type is an enzyme that in humans is encoded by the ALOX12 gene. |
| Synonyms | ALOX12; arachidonate 12-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; 12S-type; 12 Lox; 12(S) lipoxygenase; 12S LOX; 12S-lipoxygenase; 12S-LOX; Alox 12; Alox12L; Alox15; Arachidonate 12 lipoxygenase 12S type; Arachidonate 12 lipoxygenase; Arachidonate 12 lipoxygenase leukocyte type; Arachidonate 12 lipoxygenase, 12S type; Arachidonate 12 lipoxygenase, leukocyte type; EC1.13.11.31; LOG 12; LOG12; LOX12_HUMAN; Platelet type 12 lipoxygenase; Platelet type lipoxygenase 12; Platelet-type lipoxygenase 12; P-12LO; Alox12p; 9930022G08Rik |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
Alox12 involved in several pathways and played different roles in them. We selected most pathways Alox12 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Alox12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | AWAT1; CYP2P6; CYP2AD2; PLA2G4C; CYP4F2; CYP4A14; GPX3; CYP4F22; PLA2G1B; PLA2G4D |
| Metabolic pathways | MAN1B1; DHCR7; CYP2J5; MTMR7; INPP5L; LAP3; AK8; ADH6; PTGES3A; Amy1 |
| Serotonergic synapse | TPH2; PRKCA; ALOX12; HTR3A; HTR1B; PLCB2; GNG8; GABRB3; CYP2C38; KRAS |
| Inflammatory mediator regulation of TRP channels | ITPR1; NTRK1; CAMK2A; PIK3CB; PPP1CC; PLA2G4D; ACCN4; CAMK2B; PIK3CA; PRKCH |
Alox12 has several biochemical functions, for example, arachidonate 12-lipoxygenase activity, hepoxilin A3 synthase activity, hepoxilin-epoxide hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Alox12 itself. We selected most functions Alox12 had, and list some proteins which have the same functions with Alox12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arachidonate 12-lipoxygenase activity | ALOX15; ALOX12B; ALOX12; ALOX12E |
| hepoxilin A3 synthase activity | ALOX12; ALOX15 |
| hepoxilin-epoxide hydrolase activity | ALOX15; ALOX12 |
| iron ion binding | CYP4Z1; HBA-X; HBAE3; HBQ1; HBAA; CYP3A4; CYP46A1.3; CYP4F14; P4HA1B; ALOX12B |
| linoleate 13S-lipoxygenase activity | ALOX12; ALOX8; ALOX15B |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | P4HA2; ALOX12B; P4HA1A; BCO2; ADOA; ALOX5B.3; P4HA3; ALOX5B.2; TMLHE; ALOX8 |
| protein binding | MAFB; C7orf50; UBE2E2; IGFBP3; NUDCD2; KIF9; TBL3; BLOC1S4; BBC3; AK3 |
Alox12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Alox12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Alox12.
KRT5; LMNA; PLA2G2A; ITGB4; TRIB1
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