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Recombinant mouse Alox12 Protein, His-tagged

Cat.No. : Alox12-021M
Product Overview : Recombinant mouse Alox12 protein (2-664) with a C-terminal His-tag was expressed in insect cells
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  • Gene Information
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Description : This gene is from arachidonic acid. There are two main types of 12-LO, platelet-type and leukocyte-type, which share only 60% identity at the amino acid level and strongly differ in substrate specificity and enzyme kinetics. Leukocyte-type 12-LO has the ability to also produce 15-HpETE, however, platelet-type predominately forms 12-HpETE. 2 Epidermal-type 12(S)- and 12(R)-LO enzymes have also been characterized, which catalyze the synthesis of their respective stereospecific 12-HETE products.
Source : Insect Cells
Species : Mouse
Tag : His
Molecular Mass : 76 kDa
Protein length : 2-664
Purity : 80% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme required to consume 1 nmol of oxygen per minute at 37 centigrade in 0.1 M Tris-HCl, pH 7.5, containing 5 mM EDTA, 0.03% polysorbate, and 100 µM arachidonate.
Stability : ≥ 1 year
Storage : -80 centigrade
Storage Buffer : 50 mM sodium phosphate pH 7.2, 100 mM sodium chloride, 20 µM FeCl2, and 30% glycerol
Shipping : Dry ice in continental US, may vary elsewhere.
Gene Name : Alox12 arachidonate 12-lipoxygenase [ Mus musculus (house mouse) ]
Official Symbol : Alox12
Synonyms : Alox12; arachidonate 12-lipoxygenase; P-12LO; Alox12p; 9930022G08Rik; polyunsaturated fatty acid lipoxygenase ALOX12; 12S-LOX; 12S-lipoxygenase; arachidonate (12S)-lipoxygenase; arachidonate (15S)-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; arachidonate 15-lipoxygenase,15S-type; linoleate 13S-lipoxygenase; lipoxin synthase 12-LO; platelet-type lipoxygenase 12; EC 1.13.11.31; EC 1.13.11.33
Gene ID : 11684
mRNA Refseq : NM_001331118
Protein Refseq : NP_001318047
UniProt ID : P39655

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (13)

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What role does ALOX12 play in hepatitis? 12/27/2022

It is involved in the pathological process of virus-induced hepatitis, which may be related to virus clearance and liver disease recovery.

What signaling pathways are involved in ALOX12? 08/22/2022

This is associated with some signaling pathways, such as PI3K/AKT pathway and MAPK pathway.

How does ALOX12 play in obesity? 07/31/2022

ALOX12 is involved in several biological processes associated with obesity, such as adipocyte differentiation, glucose and lipid metabolism.

How does ALOX12 play in neurodegenerative diseases? 12/10/2021

ALOX12 is involved in the occurrence and development of a variety of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.

What role does ALOX12 play in diabetes? 11/24/2021

ALOX12 is involved in endothelial cell function impairment and is associated with diabetic complications.

What is the protein structure of ALOX12? 11/19/2021

This is a membrane binding protein with a core membrane binding domain and an extramembrane catalytic domain.

What is the catalytic mechanism of ALOX12? 04/07/2021

The oxidizes linolenic acid to produce 12S-LOX and 15S-LOX metabolites by oxygenation.

In what metabolic pathways does ALOX12 play a role? 12/08/2020

This protein is mainly involved in the metabolic pathway of linolenic acid, catalyzing the synthesis of 12S-LOX and 15S-LOX metabolites.

What role does ALOX12 play in cells? 07/23/2020

ALOX12 catalyzes linolenic acid to produce 12S-LOX and 15S-LOX metabolites, which have biological activities, including participating in inflammatory responses, regulating platelet activation, and regulating T cell function.

In which tissues is ALOX12 expressed? 07/15/2020

It is expressed in a variety of tissues in the human body, such as the skin, heart, lungs, liver, kidneys, intestines, and nervous system.

What are the variants of the ALOX12 gene? 05/30/2020

The human ALOX12 gene has a variety of variants, including SNP and InDel, that can lead to its dysfunction or increased risk.

Which role of ALOX12 in myocardial infarction? 03/26/2020

ALOX12 is involved in the process of myocardial cell damage after myocardial infarction, which may be related to myocardial regeneration and repair.

What diseases is ALOX12 associated with? 02/16/2020

ALOX12 is believed to be associated with a variety of diseases, such as cancer, inflammation, neurodegenerative diseases, cardiovascular disease, and more.

Customer Reviews (4)

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Reviews
11/03/2021

    It has good efficacy and high safety as an immunotherapy drug.

    03/31/2020

      ALOX12 has a good inhibitory effect on cell proliferation and survival.

      09/14/2019

        There is no interaction or influence with other drugs.

        01/27/2019

          Functionally enhanced or altered by protein modification techniques.

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