Recombinant mouse Alox12 Protein, His-tagged
Cat.No. : | Alox12-021M |
Product Overview : | Recombinant mouse Alox12 protein (2-664) with a C-terminal His-tag was expressed in insect cells |
- Specification
- Gene Information
- Related Products
Description : | This gene is from arachidonic acid. There are two main types of 12-LO, platelet-type and leukocyte-type, which share only 60% identity at the amino acid level and strongly differ in substrate specificity and enzyme kinetics. Leukocyte-type 12-LO has the ability to also produce 15-HpETE, however, platelet-type predominately forms 12-HpETE. 2 Epidermal-type 12(S)- and 12(R)-LO enzymes have also been characterized, which catalyze the synthesis of their respective stereospecific 12-HETE products. |
Source : | Insect Cells |
Species : | Mouse |
Tag : | His |
Molecular Mass : | 76 kDa |
Protein length : | 2-664 |
Purity : | 80% estimated by SDS-PAGE |
Unit Definition : | One unit is defined as the amount of enzyme required to consume 1 nmol of oxygen per minute at 37 centigrade in 0.1 M Tris-HCl, pH 7.5, containing 5 mM EDTA, 0.03% polysorbate, and 100 µM arachidonate. |
Stability : | ≥ 1 year |
Storage : | -80 centigrade |
Storage Buffer : | 50 mM sodium phosphate pH 7.2, 100 mM sodium chloride, 20 µM FeCl2, and 30% glycerol |
Shipping : | Dry ice in continental US, may vary elsewhere. |
Gene Name : | Alox12 arachidonate 12-lipoxygenase [ Mus musculus (house mouse) ] |
Official Symbol : | Alox12 |
Synonyms : | Alox12; arachidonate 12-lipoxygenase; P-12LO; Alox12p; 9930022G08Rik; polyunsaturated fatty acid lipoxygenase ALOX12; 12S-LOX; 12S-lipoxygenase; arachidonate (12S)-lipoxygenase; arachidonate (15S)-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; arachidonate 15-lipoxygenase,15S-type; linoleate 13S-lipoxygenase; lipoxin synthase 12-LO; platelet-type lipoxygenase 12; EC 1.13.11.31; EC 1.13.11.33 |
Gene ID : | 11684 |
mRNA Refseq : | NM_001331118 |
Protein Refseq : | NP_001318047 |
UniProt ID : | P39655 |
Products Types
◆ Recombinant Protein | ||
Alox12-104M | Recombinant Mouse Alox12 Protein, His-tagged | +Inquiry |
ALOX12-01H | Recombinant Human ALOX12 Protein | +Inquiry |
ALOX12-323H | Recombinant Human ALOX12 Protein, His (Fc)-Avi-tagged | +Inquiry |
Alox12-578M | Recombinant Mouse Alox12 Protein, MYC/DDK-tagged | +Inquiry |
ALOX12-2031H | Recombinant Human ALOX12 protein, His & T7-tagged | +Inquiry |
◆ Lysates | ||
ALOX12-64HCL | Recombinant Human ALOX12 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (13)
Ask a questionIt is involved in the pathological process of virus-induced hepatitis, which may be related to virus clearance and liver disease recovery.
This is associated with some signaling pathways, such as PI3K/AKT pathway and MAPK pathway.
ALOX12 is involved in several biological processes associated with obesity, such as adipocyte differentiation, glucose and lipid metabolism.
ALOX12 is involved in the occurrence and development of a variety of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.
ALOX12 is involved in endothelial cell function impairment and is associated with diabetic complications.
This is a membrane binding protein with a core membrane binding domain and an extramembrane catalytic domain.
The oxidizes linolenic acid to produce 12S-LOX and 15S-LOX metabolites by oxygenation.
This protein is mainly involved in the metabolic pathway of linolenic acid, catalyzing the synthesis of 12S-LOX and 15S-LOX metabolites.
ALOX12 catalyzes linolenic acid to produce 12S-LOX and 15S-LOX metabolites, which have biological activities, including participating in inflammatory responses, regulating platelet activation, and regulating T cell function.
It is expressed in a variety of tissues in the human body, such as the skin, heart, lungs, liver, kidneys, intestines, and nervous system.
The human ALOX12 gene has a variety of variants, including SNP and InDel, that can lead to its dysfunction or increased risk.
ALOX12 is involved in the process of myocardial cell damage after myocardial infarction, which may be related to myocardial regeneration and repair.
ALOX12 is believed to be associated with a variety of diseases, such as cancer, inflammation, neurodegenerative diseases, cardiovascular disease, and more.
Customer Reviews (4)
Write a reviewIt has good efficacy and high safety as an immunotherapy drug.
ALOX12 has a good inhibitory effect on cell proliferation and survival.
There is no interaction or influence with other drugs.
Functionally enhanced or altered by protein modification techniques.
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