|Official Full Name||arginine vasopressin receptor 2|
|Background||This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these extrarenal receptors are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.|
|Synonyms||AVPR2; arginine vasopressin receptor 2; DIR, DIR3; vasopressin V2 receptor; nephrogenic diabetes insipidus; V2R; ADHR; Antidiuretic hormone receptor; AVP R2; AVPR 2; AVPR V2; DI1; DIR 3; DIR; DIR3; MGC126533; MGC138386; NDI; Renal type arginine vasopressin receptor; Renal-type arginine vasopressin receptor; V2 receptor; V2R_HUMAN; Vasopressin V2|
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Avpr2 involved in several pathways and played different roles in them. We selected most pathways Avpr2 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Vasopressin-regulated water reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with Avpr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Phospholipase D signaling pathway||AVPR1A; PLA2G4D; GNAS; PIK3R2; RALGDS; PIK3R3; SYK; PRKCA; KIT; CYTH1|
|Neuroactive ligand-receptor interaction||PRLHR2A; CHRNA10; RXFP4; P2RX4B; PTGER2A; GLRBB; P2RY8; EDNRBA; CHRNA7; THRB|
|Vasopressin-regulated water reabsorption||CREB3L1; PRKACA; DCTN4; NSF; AQP4; DYNLL1; DCTN6; DYNC1I1; CREB5; VAMP2|
Avpr2 has several biochemical functions, for example, peptide binding, protein binding, vasopressin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Avpr2 itself. We selected most functions Avpr2 had, and list some proteins which have the same functions with Avpr2. You can find most of the proteins on our site.
|peptide binding||CSNK1D; OXTRL; Ctsl; H2-Q10; CLTB; FURIN; THOP1; CTSB; AVPR1B; ERCC3|
|protein binding||ETS2; SCYL1; EPB41; ARHGEF15; ZDHHC13; RASSF2; PURA; CCDC55; GHRL; C10orf33|
|vasopressin receptor activity||AVPR1B; AVPR1A; OXTR; OXTRL; AVPR2; INPP5K; AVPR2L; NPSR1|
Avpr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Avpr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Avpr2.