b3gat3
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  • Official Full Name
  • beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
  • Background
  • The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans.
  • Synonyms
  • B3GAT3; beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I); galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; GlcAT I; Beta 1,3 glucuronyltransferase 3; EC 2.4.1.135; Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 3; GLCATI; GlcUATI; Glucuronosyltransferase I; Sqv 8 like protein; UDP GlcUA:Gal beta 1,3 GalR glucuronyltransferase; glcUAT-I; OTTHUMP00000236456; OTTHUMP00000236457; OTTHUMP00000236459; Sqv-8-like protein; UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase
Cat.#:B3GAT3-016HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human B3GAT3 protein, GST-tagged
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Cat.#:B3GAT3-017HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human B3GAT3 protein, GST-tagged
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Cat.#:B3GAT3-1064HTag:Met|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human B3GAT3 Protein, Met & His-tagged
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Cat.#:B3GAT3-228HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human B3GAT3, His-tagged
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Cat.#:B3GAT3-7603HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human B3GAT3, His-tagged
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Cat.#:B3GAT3-2238MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse B3GAT3 Protein
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Cat.#:B3GAT3-2304ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish B3GAT3
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Cat.#:B3GAT3-8545HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human B3GAT3 293 Cell Lysate
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Involved Pathway

B3GAT3 involved in several pathways and played different roles in them. We selected most pathways B3GAT3 participated on our site, such as Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, Glycosaminoglycan biosynthesis - heparan sulfate / heparin, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with B3GAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
CHST12; CHSY3; CHST7; CSGALNACT1; CHSY1; CHPF; XYLT2; CHST14; CHST11; UST
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
HS3ST3B1B; NDST1; B3GALT6; EXTL3; GLCE; NDST3; EXTL1; EXT1C; GLCEA; HS6ST1A
Metabolic pathways
PNMT; DGAT1; MAT1A; G6PCA.1; CYP2B19; CECR1; ARSB; ADC; XYLB; ALOX15

Protein Function

B3GAT3 has several biochemical functions, for example, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity, glucuronosyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by B3GAT3 itself. We selected most functions B3GAT3 had, and list some proteins which have the same functions with B3GAT3. You can find most of the proteins on our site.
Function
Related Protein
Function galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
Related Protein B3GAT1; B3GAT2; B3GAT3; B3GAT1A
Function glucuronosyltransferase activity
Related Protein UGT1B7; UGT5C1; UGT5G1; UGT2A5; UGT1A6; CSGALNACT1; UGT2B6; UGT2A4; UGT5C2; UGT8A
Function metal ion binding
Related Protein NFS1; GDPD4; PLAGX; ZNF689; UNC13C; PPM1F; COPS5; GIT1; PCK2; SMAD6
Function protein binding
Related Protein GUCY1B3; TNPO1; CDK10; CAPNS2; RAB11FIP3; TPD52; CUTA; ZZZ3; NUDC; AHR
Function protein phosphatase activator activity
Related Protein CALM1; CALM2; CALM; CALM3; B3GAT3

Interacting Protein

B3GAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B3GAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of B3GAT3.
SEC22B; 1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate

B3GAT3 Related Articles

Gogate, SS; Nasser, R; et al. Hypoxic Regulation of beta-1,3-Glucuronyltransferase 1 Expression in Nucleus Pulposus Cells of the Rat Intervertebral Disc Role of Hypoxia-Inducible Factor Proteins. ARTHRITIS AND RHEUMATISM 63:1950-1960(2011).
Negishi, M; Dong, J; et al. Glucosaminylglycan biosynthesis: what we can learn from the X-ray crystal structures of glycosyltransferases GlcAT1 and EXTL2. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 303:393-398(2003).