b3gnt3
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  • Official Full Name
  • UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
  • Background
  • This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking.
  • Synonyms
  • B3GNT3; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3; TMEM3; B3GN T3; B3GNT 3; beta 1; 3 N acetylglucosaminyltransferase bGnT 3; beta3Gn T3; HP10328; putative type II membrane protein; transmembrane protein 3; B3GAL T8; B3GALT8; Beta 1,3 galactosyltransferase 8; Beta 3 Gal T8; Beta3Gal T8; Beta3GalT8; BGnT 3; BGnT3; Core 1 extending beta 1,3 N acetylglucosaminyltransferase; Core1 beta3GlcNAcT; UDP Gal:beta GlcNAc beta 1,3 galactosyltransferase 8; UDP GlcNAc:betaGal beta 1,3 N acetylglucosaminyltransferase 3; beta-3-Gx-T8; beta-1,3-Gn-T3; beta-1,3-GalTase 8; core1-beta3GlcNAcT; beta-1,3-N-acetylglucosaminyltransferase bGnT-3; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8; core 1 extending beta-1,3-N-acetylglucosaminyltransferase; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8; B3GN-T3; B3GNT-3; B3GAL-T8; beta3Gn-T3
Cat.#:B3GNT3-020HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human B3GNT3 protein, GST-tagged
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Cat.#:B3GNT3-021HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human B3GNT3 protein, GST-tagged
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Cat.#:B3GNT3-10104HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human B3GNT3, His-tagged
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Cat.#:B3GNT3-2241MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse B3GNT3 Protein
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Cat.#:B3GNT3-6108ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish B3GNT3
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Cat.#:B3GNT3-8543HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human B3GNT3 293 Cell Lysate
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Involved Pathway

B3GNT3 involved in several pathways and played different roles in them. We selected most pathways B3GNT3 participated on our site, such as Glycosaminoglycan metabolism, Glycosphingolipid biosynthesis - lacto and neolacto series, Keratan sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with B3GNT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan metabolism
B3GNT1; CSPG5B; B3GAT2; BGNB; STAB2; KERA; HAS3; HPSE; FMODA; GPC1B
Glycosphingolipid biosynthesis - lacto and neolacto series
ST3GAL3B; B3GNT5; B3GALT2; FUT6; ST3GAL6; B3GNT2B; FUT9; FUT4; FUT1; B3GNT3
Keratan sulfate biosynthesis
OGN; PRELP; SLC35D2; B3GNT2; B3GNT1; ST3GAL3A; FMODA; OMD; KERA; B3GNT3
Keratan sulfate/keratin metabolism
B3GNT2A; OMD; GLB1L; B3GNT1; B3GNT2; B3GNT3; SLC35D2; FMODA; ST3GAL3A
Metabolic pathways
IDO2; PCYT1BA; PNMT; AKR1B7; CYP3A7-CYP3AP1; CBR1L; MTMR7; AGLA; PLCB2; ALDH9A1B
Metabolism
SLC27A5; ACOT11; AZIN1; AK8; GGT6; CPNE3; CKB; ALOX5B.3; NEU3; CPTP
Metabolism of carbohydrates
SLC26A2; SLC25A10; CHP; EPM2A; SLC35B2; SLC25A1A; SLC5A2; B3GNT3; TREH; STAB2
Metabolism of proteins
CEACAM21; EIF5A; DCP2; TFG; TBCD; CTDSP2; CPN1; BET1; TUBA3D; ST8SIA3

Protein Function

B3GNT3 has several biochemical functions, for example, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity, galactosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by B3GNT3 itself. We selected most functions B3GNT3 had, and list some proteins which have the same functions with B3GNT3. You can find most of the proteins on our site.
Function
Related Protein
Function N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
Related Protein B3GNT1; B3GNT4; GCNT2; B3GNT3; B3GNT2
Function beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
Related Protein B3GNT6; POMGNT1; B3GNT3
Function galactosyltransferase activity
Related Protein B4GALT7; 4931440L10Rik; DPY19L1; B3GALT6; GLT8D1; POMGNT2; B3GNT7L; GALNTL4; B3GNT7; B3GNT3