|Official Full Name||bone morphogenetic protein 5|
|Background||This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.|
|Synonyms||BMP5; bone morphogenetic protein 5; BMP-5; MGC34244|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
BMP5 involved in several pathways and played different roles in them. We selected most pathways BMP5 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|TGF-beta signaling pathway||RPS6KB2; BMPR1AB; CUL1A; TGFB2; MYCB; TGIF1; AMHR2; SMAD3; BAMBI; CHD|
|Hippo signaling pathway||PARD6B; TEAD2; PRKCZ; APC2; FZD6; CTNNA3; WNT8B; BMPR1B; BMP8A; WNT4|
BMP5 has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP5 itself. We selected most functions BMP5 had, and list some proteins which have the same functions with BMP5. You can find most of the proteins on our site.
|BMP receptor binding||BMP2B; BMP5; BMP8A; BMP2; BMP4; BMP8B; BMP7; BMP7A; PYCARD; BMP3|
|cytokine activity||CD70; IL36A; BMP4; VEGFA; TNFSF11; GDF5; INHBAA; TNFSF8; Il1f9; LTA|
|growth factor activity||FGF8B; GSDF; FGF22; CECR1; IGF2B; HBEGFB; GDNF; PRL2C3; IL8L2; FGF3|
|transforming growth factor beta receptor binding||BMP7B; SPAW; SMAD2; NODAL; GDF3; LEFTY2; GDF2; GDF6; GDF9; BMP8A|
BMP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP5.