Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

BMP5

  • Official Full Name

    bone morphogenetic protein 5

  • Overview

    This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.
  • Synonyms

    BMP5; bone morphogenetic protein 5; BMP-5; MGC34244;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BMP5-27H Active Recombinant Human Bone Morphogenetic Protein 5 CHO N/A
Human BMP5-8317H Recombinant Human BMP5 Mammalian cells N/A
Human BMP5-11H Recombinant Human Bone Morphogenetic Protein 5 E.coli N/A
Human BMP5-269H Recombinant Human BMP5 Protein, GST-tagged Wheat Germ GST
Human BMP5-270H Recombinant Human BMP5 Protein, GST-tagged Wheat Germ GST
Human BMP5-05H Recombinant Human BMP5 protein, hFc-tagged HEK293 hFc Gln324-His454
Human BMP5-26H Recombinant Human Bone Morphogenetic Protein 5 Mammalian cells N/A
Human BMP5-268H Recombinant Human BMP5 Protein, GST-tagged Wheat Germ GST
Human BMP5-271H Recombinant Human BMP5 Protein, GST-tagged Wheat Germ GST
Human BMP5-272H Recombinant Human BMP5 Protein, GST-tagged Wheat Germ GST
Human BMP5-3074HCL Recombinant Human BMP5 cell lysate Human Cell N/A
Human BMP5-259H Recombinant Human BMP5 Protein, His-tagged E.coli His Ala317~His454
Human BMP5-15H Recombinant Active Human BMP5 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human BMP5-014H Active Recombinant Human BMP5 Protein E. coli
Human BMP5-221HG Active GMP Recombinant Human BMP5 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human BMP-5(NP_066551.1) was expressed with Fc tag at the C-terminal.
Human BMP5-1726HF Recombinant Full Length Human BMP5 Protein, GST-tagged In Vitro Cell Free System GST 454 amino acids
Human BMP5-4365H Recombinant Human BMP5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BMP5-280H Active Recombinant Human BMP5 Protein (Val341-His454), C-His tagged, Animal-free, Carrier-free E.coli C-His Val341-His454
Human BMP5-4365H-B Recombinant Human BMP5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Bmp5-260M Recombinant Mouse Bmp5 Protein, His-tagged E.coli His Ala315~His452
Zebrafish BMP5-11279Z Recombinant Zebrafish BMP5 Mammalian Cell His
Chicken BMP5-6705C Recombinant Chicken BMP5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BMP5 Related Articles
  • BMP5 Related Gene Family
  • BMP5 Related Research Area

BMP5 involved in several pathways and played different roles in them. We selected most pathways BMP5 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TGF-beta signaling pathwayBMPR2B;AMHR2;BMP7B;RPS6KB1;PPP2CB;BMPR1AB;CHRD;RHOAB;BMP4
Hippo signaling pathwayBIRC5;WWTR1;WNT1;TCF7L2;AREG;YWHAE;WNT9A;TP73;AXIN1

BMP5 has several biochemical functions, for example, BMP receptor binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP5 itself. We selected most functions BMP5 had, and list some proteins which have the same functions with BMP5. You can find most of the proteins on our site.

Function Related Protein
BMP receptor bindingBMP3;PYCARD;BMP7B;BMP2;BMP7;BMP4;BMP6;BMP7A;BMP5
cytokine activityGDF10B;IFNA8;IL5;LIF;AREG;IFNA13;IFNA1;WNT7A;BMP8B
growth factor activityTHBS4;FGF13;HBEGF;VEGFA;FGF12A;FBRS;PDGFB;FGF8A;REG1A
transforming growth factor beta receptor bindingGDF3;BMP15;BMP7;MSTN;BMP5;SMURF2;BMP10;MSTNB;GDF1

BMP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP5.

Endo, Y; Ishiwata-Endo, H; et al. Cloning and characterization of chicken alpha 5 integrin: Endogenous and experimental expression in early chicken embryos. MATRIX BIOLOGY 32:381-386(2013).
Guan, QN; Li, SY; et al. Reduction of chronic rejection of renal allografts by anti-transforming growth factor-beta antibody therapy in a rat model. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F199-F207(2013).
TGF
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the role of the protein BMP5 in cellular signaling? 12/01/2022

BMP5, a member of the bone morphogenetic protein family, functions by binding to cell surface receptors and activating the Smad signaling pathway. This leads to the phosphorylation and nuclear localization of transcription factors, thereby regulating gene expression. BMP5 plays a crucial role in cellular proliferation, differentiation, and fate determination. Its signaling mechanism involves various molecular regulations, including the involvement of co-receptors, signal transduction mediators, and downstream effectors.

What are the downstream target genes regulated by BMP5? 02/18/2022

BMP5 regulates the expression of various downstream target genes involved in multiple cellular processes. These include genes encoding transcription factors, extracellular matrix components, growth factors, and signaling molecules. Examples of BMP5 target genes include Runx2, Osterix, Sox9, Noggin, and Gremlin. Through the activation of these target genes, BMP5 influences cell fate determination, osteoblast differentiation, chondrogenesis, and tissue homeostasis.

How does BMP5 contribute to skeletal development and bone formation? 08/03/2021

BMP5 plays a critical role in skeletal development and bone formation. It promotes the commitment of mesenchymal stem cells to the osteoblast lineage and stimulates their differentiation into mature osteoblasts. BMP5 also regulates the proliferation and survival of osteoblasts, as well as the synthesis and mineralization of the extracellular matrix. Additionally, BMP5 interacts with other BMP family members and signaling molecules to coordinate the complex processes of skeletal patterning, limb development, and bone remodeling.

What is the involvement of BMP5 in pathological conditions, such as skeletal disorders and cancer? 07/28/2021

Dysregulation of BMP5 expression or signaling has been implicated in various skeletal disorders, including osteoporosis, osteoarthritis, and skeletal dysplasias. BMP5 mutations or alterations in its expression levels can disrupt normal bone development and contribute to skeletal abnormalities. Additionally, BMP5 has been found to play a role in cancer progression. Depending on the context, BMP5 can act as either a tumor suppressor or a promoter by influencing cell proliferation, apoptosis, angiogenesis, and metastasis.

What are the current challenges and future directions in BMP5 research? 02/20/2019

Despite significant progress, several challenges remain in BMP5 research. Understanding the precise mechanisms underlying BMP5 signaling and its cross-talk with other signaling pathways is crucial. Additionally, investigating the context-dependent functions of BMP5 in different tissues and disease conditions is important for developing targeted therapies. Future research should focus on elucidating the regulatory networks controlling BMP5 expression and identifying novel therapeutic targets within the BMP5 signaling pathway. Moreover, studying the potential of BMP5 as a diagnostic or prognostic marker in various diseases would further expand its clinical relevance.

How is the expression of BMP5 regulated in different tissues and developmental stages? 05/10/2017

The expression of BMP5 is tightly regulated through a combination of transcriptional, post-transcriptional, and post-translational mechanisms. Transcription factors, such as Smads, homeobox proteins, and other tissue-specific regulators, bind to the promoter region of the BMP5 gene, modulating its expression. Additionally, microRNAs and RNA-binding proteins can influence the stability and translation of BMP5 mRNA. Furthermore, epigenetic modifications, including DNA methylation and histone acetylation, play a role in regulating BMP5 expression during development and in response to environmental cues.

Are there any therapeutic implications of targeting BMP5 in disease treatment? 04/14/2017

Targeting BMP5 signaling holds therapeutic potential for various diseases. For example, in bone-related disorders, modulating BMP5 activity could be explored to promote bone regeneration or inhibit excessive bone loss. In cancer, therapeutic strategies targeting BMP5 signaling could be designed to regulate tumor growth, metastasis, or sensitize cancer cells to existing therapies. However, further research is needed to fully understand the complex role of BMP5 in disease pathogenesis and to develop targeted therapies that specifically modulate BMP5 activity.

Customer Reviews (3)

Write a review
Reviews
01/19/2021

    Revolutionizing the art of experimentation, this reagent blazes a trail of innovation.

    03/05/2020

      By using this reagent, I am able to delve deeper into my research topics, deriving more persuasive conclusions.

      03/25/2017

        The reagent showcases remarkable versatility and unwavering stability when it comes to the manipulation of intricate samples.

        Ask a Question for All BMP5 Products

        Required fields are marked with *

        My Review for All BMP5 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends