BRCA1
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Official Full Name
breast cancer 1, early onset
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Overview
Breast Cancer Gene 1 (BRCA1) is phosphorylated at Ser1524, and occurs in response to ionizing and ultraviolet radiation. -
Synonyms
BRCA1; breast cancer 1, early onset; breast cancer type 1 susceptibility protein; BRCA1/BRCA2 containing complex; subunit 1; BRCC1; PPP1R53; protein phosphatase 1; regulatory subunit 53; RNF53; RING finger protein 53; BRCA1/BRCA2-containing complex, subunit 1; protein phosphatase 1, regulatory subunit 53; breast and ovarian cancer susceptibility protein 1; breast and ovarian cancer sususceptibility protein 1; IRIS; PSCP; BRCAI; PNCA4; BROVCA1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Sf21 Insect Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- BRCA1 Related Articles
- BRCA1 Related Research Area
BRCA1 involved in several pathways and played different roles in them. We selected most pathways BRCA1 participated on our site, such as Fanconi anemia pathway, Ubiquitin mediated proteolysis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi anemia pathway | TELO2;FANCA;PMS2;RAD51C;C19orf40;MLH1;PALB2;TOP3B;RPA1 |
| Ubiquitin mediated proteolysis | SIAH1;PIAS4B;BIRC2;UBE2L3A;ERCC8;SOCS3B;UBE2F;UBE2NB;CUL3 |
| PIK-Akt signaling pathway | COL24A1;ANGPT1;GYS1;ITGB8;VEGFC;TNR;COL6A5;PRLR;ITGA8 |
| MicroRNAs in cancer | MDM4;HRAS;CDC25B;GLS2;ITGA5;SOX4;MDM2;CD44;CCNE1 |
BRCA1 has several biochemical functions, for example, DNA binding, RNA binding, androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRCA1 itself. We selected most functions BRCA1 had, and list some proteins which have the same functions with BRCA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | SYCP3;THAP5;FOXO1B;TCEB3C;LASS5;IRX7;ZNF80;IRF7;ZNF493 |
| RNA binding | RPS4Y1;ARHGEF28;PABPC1A;RNMT;PCBP4;UNC50;NHP2L1A;EIF4E1B;RAVER2 |
| androgen receptor binding | TCF21;PRMT2;CDK7;PRKCBB;NRIP1;KAT5;PRKCB;FOXH1;KDM4C |
| damaged DNA binding | MPG;NEIL1;RAD52;BRCA1;TDG;NEIL2;HMGB1;RAD18;RAD23A |
| enzyme binding | SUDS3;ARRB2;N4BP2L2;CDC20;RCOR3;UGT1A6A;BIRC5;CBX1;MLEC |
| ligase activity | TRIM50;RNF111;RNF25;UBE2L3B;E4F1;TRIM27;HECW1;MYLIPB;UBR3 |
| protein binding | ORMDL3;ZBTB22;ZKSCAN1;MGRN1;TBX6;EBF2;INTS4;AKR1A1;NUDT18 |
| transcription coactivator activity | JUPA;MAML1;TCERG1;MYOD1;MLL5;ING4;USP16;MED21;TAF6L |
| transcription regulatory region DNA binding | FOXI1;GABPB2;OVOL2;CDK9;RBBP5;TAF9;ZNF831;GATA3;YAP1 |
| tubulin binding | STMN2A;AGTPBP1;STMN1;NCALD;STMN3;EML1;BRCA1;STMN2B;TPPP |
| ubiquitin protein ligase binding | UBXN6;CD40;SMAD5;ASB4;UBE2KA;TMBIM6;NAE1;PDE4D;TRIB1 |
| ubiquitin-protein transferase activity | FBXL3;UBE2S;MYLIP;TRAF4;SHPRH;UBE3A;TRIM37;FBXL6;BIRC3 |
| zinc ion binding | FHL1B;RARB;UBOX5;VPS41;PDZRN4;RNF113A;ZDHHC16B;RNF207;RC3H2 |
BRCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRCA1.
BRIP1; BARD1
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