brms1
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  • Official Full Name
  • breast cancer metastasis suppressor 1
  • Background
  • This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.
  • Synonyms
  • BRMS1; breast cancer metastasis suppressor 1; breast cancer metastasis-suppressor 1; DKFZP564A063; AV003220; AW554636; MGC95128; OTTHUMP00000235056; OTTHUMP00000235057; OTTHUMP00000235060; OTTHUMP00000235062
Cat.#:BRMS1-10293HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BRMS1, GST-tagged
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Cat.#:BRMS1-341HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BRMS1 Protein, GST-tagged
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Cat.#:BRMS1-405HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human breast cancer metastasis suppressor 1, T7 tagged
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Cat.#:BRMS1-5006HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BRMS1, T7-tagged
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Cat.#:BRMS1-1017RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat BRMS1 Protein
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Cat.#:BRMS1-567RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BRMS1 Protein, His-tagged
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Cat.#:BRMS1-10449ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BRMS1
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Cat.#:BRMS1-8406HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BRMS1 293 Cell Lysate
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Involved Pathway

BRMS1 involved in several pathways and played different roles in them. We selected most pathways BRMS1 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDACs deacetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRMS1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
SMARCD3; KIAA1267; USP22; KAT7B; ATXN7; ACTL6B; PADI3; ARID1A; TADA2B; SMARCD3B
Chromatin organization
MSL1; MCRS1; BRD1; SMARCA2; KDM7AB; MTA2; USP22; KDM5A; MORF4L2; BRMS1
HDACs deacetylate histones
MBD3A; PHF21A; CHD4A; CHD4; ARID4A; MTA1; SAP30L; KDM1A; MBD3; HMG20B

Protein Function

BRMS1 has several biochemical functions, for example, NF-kappaB binding, contributes_to histone deacetylase activity, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRMS1 itself. We selected most functions BRMS1 had, and list some proteins which have the same functions with BRMS1. You can find most of the proteins on our site.
Function
Related Protein
Function NF-kappaB binding
Related Protein ANXA4; COMMD7; TAF4B; EP300; CDKN2A; BCL10; GSK3B; HDAC3; MTDH; CDK5RAP3
Function contributes_to histone deacetylase activity
Related Protein BRMS1; SIN3AA; BRMS1LA; BRMS1L; SALL1; SIN3B; SIN3A; SUDS3
Function histone deacetylase binding
Related Protein ZMYND15; YY1; CAMTA2; MEF2A; PKN2; HDAC6; HDAC3; PHB; MAPK8; KAT2A
Function protein binding
Related Protein LINC00482; KPNA4; RNF146; PPEF1; MRPL13; ATP6V1H; GNE; TAB1; CRP; BAG6

Interacting Protein

BRMS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRMS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRMS1.
HDAC1; HDAC2; SMARCE1; NMI; CEP70; HDAC4

BRMS1 Related Articles

Xiao, LF; Harihar, S; et al. Imaging of epidermal growth factor receptor on single breast cancer cells using surface-enhanced Raman spectroscopy. ANALYTICA CHIMICA ACTA 843:73-82(2014).
Chimonidou, M; Kallergi, G; et al. BRSM1 Promoter Methylation Provides Prognostic Information in Primary Breast Tumors. MOLECULAR CANCER RESEARCH 11:1248-1257(2013).