• Official Full Name
  • Cdk5 and Abl enzyme substrate 1
  • Background
  • This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
  • Synonyms
  • CABLES1; Cdk5 and Abl enzyme substrate 1; CABL1; IK3-1; CABLES; HsT2563; CDK5 and ABL1 enzyme substrate 1; interactor with CDK3 1;
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CABLES1 Protein, GST-Tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CABLES1 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CABLES1
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ABL1 (Active), GST-tagged
Source (Host):Species:Human
Product nameRecombinant Human CABLES1 cell lysate

Involved Pathway

CABLES1 involved in several pathways and played different roles in them. We selected most pathways CABLES1 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CABLES1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Factors involved in megakaryocyte development and platelet production
ITPK1; SH2B3; GATA6; MGC173646; DOCK10; KDM1A; PHF21A; NFE2; KIF4; H3F3D

Protein Function

CABLES1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CABLES1 itself. We selected most functions CABLES1 had, and list some proteins which have the same functions with CABLES1. You can find most of the proteins on our site.
Related Protein
Function protein binding
Related Protein AK8; THEMIS2; RPL10; ESR1; C16orf79; RPL10A; KIF3A; C16orf59; LIN37; GADD45A

Interacting Protein

CABLES1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CABLES1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CABLES1.
CDK5; TP63; TP53; ALB