CACNA1A Protein, calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

CACNA1A

Home / Products / CACNA1A

CACNA1A

Official Full Name calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Background Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3 UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Mar 2010]
Synonyms CACNA1A; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; BI; EA2; FHM; MHP; APCA; HPCA; MHP1; SCA6; CAV2.1; CACNL1A4; voltage-dependent P/Q-type calcium channel subunit alpha-1A; brain calcium channel 1; brain calcium channel I; calcium channel, L type, alpha-1 polypeptide; voltage-gated calcium channel subunit alpha Cav2.1;
 
Search Results
Sorry that we did not find a match to your query.Please refine your search using the following instructions:
1. In the search box, enter only accession number such as NM_001200, or gene symbol, such as BMP2, or protein name, like Bone morphogenetic protein 2 precursor.
2. Do not include product type descriptions, such as clone, antibody, or shRNA, etc.
3. Do not include species in search.
4. When one key word does not return any result, try the following options:
    A. Try another name: e.g., CD3E for T3E
    B. Try both full and abbreviated gene names, e.g., relaxin 3 vs. RLN3
    C. Remove space or dash (-) in your search terms, like IL2 for IL-2.
Alternatively, our Customer Care and Technology team is standing by to take your call (631-559-9269) or Email (info@creative-biomart.com) to personally match your needs with the most appropriate Creative BioMart product.

CACNA1A involved in several pathways and played different roles in them. We selected most pathways CACNA1A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CACNA1A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA1A itself. We selected most functions CACNA1A had, and list some proteins which have the same functions with CACNA1A. You can find most of the proteins on our site.

Function Related Protein

CACNA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA1A.

Spillane, J; Ermolyuk, Y; et al. Lambert-Eaton syndrome IgG inhibits transmitter release via P/Q Ca2+ channels. NEUROLOGY 84:575-579(2015).
Billings, SE; Clarke, GL; et al. ELKS1 and Ca2+ channel subunit beta 4 interact and colocalize at cerebellar synapses. NEUROREPORT 23:49-54(2012).

Related Services & Products

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy