CACNG2
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Official Full Name
Cacng2 calcium channel, voltage-dependent, gamma subunit 2
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Synonyms
CACNG2; calcium channel, voltage-dependent, gamma subunit 2; voltage-dependent calcium channel gamma-2 subunit; TARP gamma 2; TARP gamma-2; transmembrane AMPAR regulatory protein gamma-2; neuronal voltage-gated calcium channel gamma-2 subunit; stg; wag; waggler; AW060990; stargazer; stargazin; B230105C07Rik; B930041E13Rik; MGC123981;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CACNG2 Related Articles
CACNG2 involved in several pathways and played different roles in them. We selected most pathways CACNG2 participated on our site, such as Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adrenergic signaling in cardiomyocytes | SCN4BA;PPP2R5EB;PIK3R5;PPP1CAB;GNAI2A;CREB3;KCNE1;ATP1A1A.1;CAMK2A |
| Arrhythmogenic right ventricular cardiomyopathy | CTNNA1;CACNG3;DMD;CTNNA2;CACNG2;DSG2;DSC2;DAG1;CDH2 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ACTN3;ITGA1;ITGB5;SGCG;RYR2;CACNG4;ACTG1;DSC2;JUP |
| Cardiac muscle contraction | ATP1B2B;CACNA2D1;CACNG7A;UQCRQ;COX4I1;COX7A1;CACNG4;MYH7;COX8A |
| Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels | CACNB4B;CACNG2;CACFD1;CACNG2B |
| Developmental Biology | FGF10B;PLXNC1;DLG3;CDK5R1B;MYOD1;CACNG3;RHOB;MYL12B;SALL4 |
| Dilated cardiomyopathy | TNF;PRKACA;ITGAV;TGFB1;SGCB;ITGB7;PRKACB;ITGA7;CACNG4 |
| Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | NSFA;AKAP5;GRIP1;HAND2;CACNG3;CACNG2;PICK1;MYO6;NSFB |
CACNG2 has several biochemical functions, for example, channel regulator activity, ionotropic glutamate receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNG2 itself. We selected most functions CACNG2 had, and list some proteins which have the same functions with CACNG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| channel regulator activity | CACNG8;CACNG2B;CACNG3;CACNG2A;CNIH3;CACNG2;SNF8;CACNG7A;CACNG4 |
| ionotropic glutamate receptor binding | RAB4A;DLG3;NETO1;DLG2;SHANK1;FUS;CANX;SHANK2;GNAS |
| protein binding | GOSR2;ITGAL;ELK1;ACYP2;FAM98A;ZNF649;MOB1A;TDO2;ATP6V1E2 |
| voltage-gated calcium channel activity | CACNB3A;CACNA1DA;TPC3;CACNG6;CACNG2A;CACNG1A;PKD2;CACNB4A;NCS1 |
CACNG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNG2.
SRPK2
- Q&As
- Reviews
Q&As (7)
Ask a questionPost-translational modifications like phosphorylation may exist on CACNG2, influencing its activity or interactions.
Dysregulation or mutations in CACNG2 have been implicated in neurological conditions, including certain forms of epilepsy.
Genetic mutations in the CACNG2 gene can alter its regulatory influence on calcium channels, affecting neuronal communication and other related functions.
By associating with calcium channels, CACNG2 can affect channel gating, localization, and calcium ion permeation properties.
CACNG2 is mainly expressed in the brain, particularly in synapses.
CACNG2 primarily interacts with the alpha-1 subunit of calcium channels and may associate with other channel proteins or regulatory factors.
CACNG2 functions as an auxiliary subunit, modulating the trafficking, activity, and surface expression of voltage-gated calcium channels.
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