cacng3
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  • Official Full Name
  • calcium channel, voltage-dependent, gamma subunit 3
  • Background
  • The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy.
  • Synonyms
  • CACNG3; calcium channel, voltage-dependent, gamma subunit 3; voltage-dependent calcium channel gamma-3 subunit; CACNG 3; Cacng2; Calcium channel voltage dependent gamma subunit 3; Neuronal voltage gated calcium channel gamma 3 subunit; Voltage dependent calcium channel gamma 3 subunit; Voltage gated calcium channel gamma subunit; TARP gamma-3; voltage-gated calcium channel gamma subunit; transmembrane AMPAR regulatory protein gamma-3; neuronal voltage-gated calcium channel gamma-3 subunit
Cat.#:CACNG3-0276HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CACNG3 Protein, GST-Tagged
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Cat.#:CACNG3-2625MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CACNG3 Protein
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Cat.#:CACNG3-1072RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CACNG3 Protein
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Cat.#:CACNG3-355CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CACNG3 Protein, His-tagged
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Cat.#:CACNG3-604RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CACNG3 Protein, His-tagged
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Cat.#:CACNG3-6227CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CACNG3
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Cat.#:CACNG3-270HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CACNG3 cell lysate
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Involved Pathway

CACNG3 involved in several pathways and played different roles in them. We selected most pathways CACNG3 participated on our site, such as Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNG3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adrenergic signaling in cardiomyocytes
MAPK13; ATP1B3A; ACTC1B; ATF2; CACNG7A; ATP2A2; ATP1B1; ATP1A1A.1; BCL2; CACNA1SA
Arrhythmogenic right ventricular cardiomyopathy
CTNNA1; CACNG3; DSG2; DAG1; DSC2; DMD; CDH2; JUP; DES; DSP
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
SGCB; CACNB3; ITGA10; ACTN2; ITGA4; ITGB5; TCF7L2; ATP2A2; ITGA1; DMD
Cardiac muscle contraction
CACNB4A; COX4I2; CACNG1; TNNC1B; CACNA2D1A; CACNG8; MYL3; CACNB2; MYL2; UQCRC1
Developmental Biology
SREBF2; LGI1B; DRAP1; COL9A1; EFNA2A; LGI2; FGF10B; KALRN; GDNF; LEFTY1
Dilated cardiomyopathy
GNAS; CACNB3; CACNG8; ATP2A2; SLC8A1; CACNG3; CACNA2D1; LAMA2; CACNG1; MYL3
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
CACNG3; GRIP1; PICK1; HAND2; NSFB; CACNG2; AKAP5; NSFA; MYO6
Hypertrophic cardiomyopathy (HCM)
EMD; TNF; ITGA1; SGCA; ITGA8; TTN; ITGA6; ACTG1; SGCD; ACE

Protein Function

CACNG3 has several biochemical functions, for example, channel regulator activity, voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNG3 itself. We selected most functions CACNG3 had, and list some proteins which have the same functions with CACNG3. You can find most of the proteins on our site.
Function
Related Protein
Function channel regulator activity
Related Protein SNF8; CACNG7A; CACNG8A; CACNG8; CACNG7; CACNG2B; CACNG2A; CACNG3; CNIH3; CACNG2
Function voltage-gated calcium channel activity
Related Protein IL1RAPL1; CACNB2; CACNG2; NCS1; ATP6V0CB; CACNG4; GAS6; CACNB4B; CACNG2B; CACNA2D2

CACNG3 Related Articles

Endoh, T; et al. Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium currents in rat nucleus tractus solitarius. BRAIN RESEARCH 1024:212-224(2004).
Yamada, E; Endoh, T; et al. Angiotensin II-induced inhibition of calcium currents via G(q/11)-protein involving protein kinase C in hamster submandibular ganglion neurons. NEUROSCIENCE RESEARCH 43:179-189(2002).