Recombinant Full Length Macaca Fascicularis Voltage-Dependent Calcium Channel Gamma-3 Subunit(Cacng3) Protein, His-Tagged

• Cat.No.: RFL36730MF
• Product Overview: Recombinant Full Length Macaca fascicularis Voltage-dependent calcium channel gamma-3 subunit(CACNG3) Protein (Q4R589) (1-315aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
• Tag: His
• Form: Lyophilized powder
• Protein Length: Full Length (1-315)
• AA Sequence: MRMCDRGIQMLITTVGAFAAFSLMT IAVGTDYWLYSRGVCRTKSTSDNET SRKNEEVMTH SGLWRTCCLEGAFRGVCKKIDHFPE DADYEQDTAEYLLRAVRASSVFPIL SVTLLFFGGL CVAASEFHRSRHNVILSAGIFFVSA GLSNIIGIIVYISANAGDPGQRDSK KSYSYGWSFY FGAFSFIIAEIVGVVAVHIYIEKHQ QLRAKSHSEFLKKSTFARLPPYRYR FRRRSSSRST EPRSRDLSPISKGFHTIPSTDISMF TLSRDPSKITMGTLLNSDRDHAFLQ FHNSTPKEFK ESLHNNPANRRTTPV
• Purity: Greater than 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: CACNG3
• Synonyms: CACNG3; QccE-13852; Voltage-dependent calcium channel gamma-3 subunit; Neuronal voltage-gated calcium channel gamma-3 subunit; Transmembrane AMPAR regulatory protein gamma-3; TARP gamma-3
• UniProt ID: Q4R589

Gene Information

• Gene Name: CACNG3
• Synonyms: CACNG3; QccE-13852; Voltage-dependent calcium channel gamma-3 subunit; Neuronal voltage-gated calcium channel gamma-3 subunit; Transmembrane AMPAR regulatory protein gamma-3; TARP gamma-3
• UniProt ID: Q4R589

Reviews

07/06/2022

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05/17/2021

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01/28/2021

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Q&As

Have any post-translational modifications been identified on CACNG3?

Techniques like mass spectrometry might reveal specific post-translational modifications on CACNG3.

How do genetic mutations in the CACNG3 gene influence its regulatory role?

Genetic mutations in the CACNG3 gene can alter its regulatory function, impacting the dynamics and behavior of related calcium channels.

Are there specific proteins known to interact directly with CACNG3?

CACNG3 primarily interacts with the alpha-1 subunit of calcium channels and may have associations with other channel proteins.

Which human tissues or cells predominantly express CACNG3?

CACNG3 is mainly expressed in the brain, especially within neural tissues.

Are there any diseases or disorders directly linked to CACNG3 dysfunction?

Dysfunctions or mutations in CACNG3 are implicated in certain neurological conditions, although deeper research is essential for concrete associations.

How does CACNG3 modulate the function of associated calcium channels?

By binding to calcium channels, CACNG3 can influence the channel's gating dynamics, its localization, and the properties of calcium ion permeation.

What is the main biological role of CACNG3 in relation to calcium channels?

CACNG3 serves as an auxiliary subunit, contributing to the modulation of the trafficking, activity, and surface expression of voltage-gated calcium channels.