calcrl
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  • Official Full Name
  • calcitonin receptor-like
  • Background
  • CRLR is a receptor for calcitonin gene related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.
  • Synonyms
  • CALCRL; calcitonin receptor-like; CRLR; CGRPR; calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; calcitonin receptor-like receptor;
Cat.#:CALCRL-0298HTag:N/A
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CALCRL Protein
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Cat.#:CALCRL-0299HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CALCRL Protein, GST-Tagged
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Cat.#:CALCRL-1090RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CALCRL Protein
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Cat.#:CALCRL-3992CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CALCRL
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Cat.#:CALCRL-273HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CALCRL cell lysate
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Involved Pathway

CALCRL involved in several pathways and played different roles in them. We selected most pathways CALCRL participated on our site, such as Calcitonin-like ligand receptors, Class B/2 (Secretin family receptors), Endothelin, which may be useful for your reference. Also, other proteins which involved in the same pathway with CALCRL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcitonin-like ligand receptors
CALCB; RAMP3; CALCA; RAMP2; ADM2; RAMP1; ADM; ADM2A; CALCRL
Class B/2 (Secretin family receptors)
RAMP1; PTHLH; SCT; EMR2; ADCYAP1B; EMR1; GNB5A; ADM; CRHR2; GCGA
Endothelin
RAMP1; MYL1; ECE1; CALCRL; EDNRB; EDN1; CALCA; CNN1; EDNRA
G alpha (s) signalling events
GHRH; PDE10A; NPSR1; TAAR1; ADCYAP1B; RXFP2; PTH2; ADM2A; CRHR2; ADCYAP1R1
GPCR downstream signaling
OPN1SW1; PNOC; RGS19; CCR8; ARHGEF25; GPR132B; APPB; AGTR2; RGS1; PYY
GPCR ligand binding
CCRL2; GPR31B; EMR4; AMCF-II; PROK2; OXGR1A.2; LTB4R; FZD10; GPR77; OPN1LW1
GPCRs, Class B Secretin-like
CRHR1; ADCYAP1R1; CD97; EMR2; ELTD1; LPHN1; EMR1; CALCRL; CRHR2
Neuroactive ligand-receptor interaction
CSH1; TAAR12I; PRLR; CGNRH-R; GRIA1B; TAAR5; PRLHR; GRIA2A; GPR35; UTS2R

Protein Function

CALCRL has several biochemical functions, for example, G-protein coupled receptor activity, adrenomedullin receptor activity, calcitonin gene-related peptide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CALCRL itself. We selected most functions CALCRL had, and list some proteins which have the same functions with CALCRL. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor activity
Related Protein TM2D1; GPR31B; TAAR7B; OR4N4; RRH; TAAR12J; OLFCG3; GPR126; FPR3; TMTOPSA
Function adrenomedullin receptor activity
Related Protein GPR182; CALCRL
Function calcitonin gene-related peptide receptor activity
Related Protein CRCP; CALCRL
Function calcitonin receptor activity
Related Protein CALCRL; CALCRLA; CALCR; RAMP1
Function protein binding
Related Protein NDC80; GGACT; PFDN5; LRRC6; BIRC7; NUDT22; CCDC47; ZNF205; GCC2; CDK5RAP3
Function protein transporter activity
Related Protein KPNA3; AP2B1; AP2A2; KPNA5; AP1G2; USO1; MLC1; AP1S1; TSNAX; SEC62

Interacting Protein

CALCRL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALCRL here. Most of them are supplied by our site. Hope this information will be useful for your research of CALCRL.
RAMP2; ADM; CALCA; CALCA; RAMP1

CALCRL Related Articles

Vecsei, L; Szok, D; et al. CGRP antagonists and antibodies for the treatment of migraine. EXPERT OPINION ON INVESTIGATIONAL DRUGS 24:31-41(2015).
Edvinsson, L; Warfvinge, K; et al. CGRP Receptor Antagonism and Migraine Therapy. CURRENT PROTEIN & PEPTIDE SCIENCE 14:386-392(2013).