CASP10
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Official Full Name
caspase 10, apoptosis-related cysteine peptidase -
Overview
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] -
Synonyms
CASP10;caspase 10, apoptosis-related cysteine peptidase;MCH4;ALPS2;FLICE2;caspase-10;CASP-10;FADD-like ICE2;apoptotic protease MCH-4;ICE-like apoptotic protease 4;interleukin-1B-converting enzyme 2;caspase 10, apoptosis-related cysteine protease;FAS-associated death domain protein interleukin-1B-converting enzyme 2
Recombinant Proteins
- Human
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
CASP10 involved in several pathways and played different roles in them. We selected most pathways CASP10 participated on our site, such as Apoptosis,RIG-I-like receptor signaling pathway,TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RIG-I-like receptor signaling pathway | MAPK10,TRIM25,IFNK,IFNA2,DHX58,IFNA16,NLRX1,OTUD5,TRAF3,TNF |
| Apoptosis | HDR,RNF8,NMT1,IKBKG,LMNB1,BNIP3LB,CTNNB2,CLSPN,IRF4,PIK3CD |
| Tuberculosis | ITGB2,IFNA6,Cd209g,HLA-DRB1,CD209B,ITGAM,cgr2b,Il23a,SPHK1,FCGR4 |
| TNF signaling pathway | ITCH,MAP2K3,CCL5,LIF,MAP3K7,ICAM1,VEGFC,MAPK3,MAPK13,CFLAR |
| Hepatitis B | PIK3R1,CYCS,IFNA21,IFNA17,IL6,MAPK1,IKBKG,IFNB1,HBXIP,CCNE1 |
Protein Function
CASP10 has several biochemical functions, for example, cysteine-type endopeptidase activity,cysteine-type endopeptidase activity involved in apoptotic signaling pathway,death effector domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP10 itself. We selected most functions CASP10 had, and list some proteins which have the same functions with CASP10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activity | UCHL1,CASP3A,USP24,USP13,CTSO,CTSLA,USP3,CASP2,USP37,ESPL1 |
| death effector domain binding | CFLAR,NOL3,CASP8L1,CASP8,CFLARA,FADD |
| protein binding | SCMH1,ZNF643,SERINC1,PTPN13,RPA2,TMED9,SRM,CHMP4C,UBA52,H2-AB1 |
| cysteine-type endopeptidase activity involved in apoptotic signaling pathway | CASP9,CASP2,CASP8L1,CFLARA,CFLAR,CASP14,CASP8 |
| ubiquitin protein ligase binding | TP53,UBXN1,RPA3,TRAF4,MYOD1,CDC34B,AICDA,UBE2H,POU5F1,UBE2S |
Interacting Protein
CASP10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP10 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP10.
FADD;CASP8;CFLAR;RIOK3;XIAP
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