CASP10

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CASP10

Official Full Name caspase 10, apoptosis-related cysteine peptidase
Background This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Synonyms CASP10; caspase 10, apoptosis-related cysteine peptidase; MCH4; ALPS2; FLICE2; caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; FAS-associated death domain protein interleukin-1B-converting enzyme 2
    • Species :
    • Human
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CASP10-0414H Recombinant Human CASP10 Protein, GST-Tagged Wheat Germ GST
    Human CASP10-247H Recombinant Human CASP10, His-tagged E.coli His
    Human CASP10-26813TH Recombinant Human CASP10 E.coli N/A
    Human CASP10-26815TH Recombinant Human CASP10 E.coli N/A
    Human CASP10-299H Recombinant Human CASP10 Protein, His-tagged E.coli His
    Human CASP10-300H Recombinant Human CASP10 Protein, His-tagged E.coli His
    Human CASP10-557H Recombinant Human CASP10 Mammalian Cell His
    Human CASP10-597H Recombinant Human Caspase 10, Apoptosis-related Cysteine Peptidase E.coli N/A
    Human CASP10-598H Recombinant Human Caspase 10, Apoptosis-related Cysteine Peptidase E.coli N/A

    CASP10 involved in several pathways and played different roles in them. We selected most pathways CASP10 participated on our site, such as Apoptosis, RIG-I-like receptor signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis CASP8; PRKACAB; CASP9; ENDOG; AKT1; BMX; DSG1; BIRC2; STK24; BADB
    RIG-I-like receptor signaling pathway CXCL10; IFNA4; IFNA8; ATG5; IFNK; DDX3; MAPK14B; PIN1; NFKBIAB; IFNA2
    TNF signaling pathway AKT1; AKT2; IL1B; CXCL10; PIK3R1; TRAF3; CXCL1; PIK3CG; MAP2K3; MAP3K5
    Tuberculosis BCL10; CALM1; IFNA10; MAPK3; CLEC4E; LSP1; IL18; RAF1; RELA; CASP8
    Hepatitis B IRF7; YWHAZ; EGR3; EP300; RELA; AKT1; MAP2K4; NFKBIA; APAF1; KRAS

    CASP10 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, death effector domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP10 itself. We selected most functions CASP10 had, and list some proteins which have the same functions with CASP10. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase activity FAM49BA; CFLARA; USP43A; USP40; CTSB; Ctsl; SFRP1; CASP6L2; USP12; USP13
    cysteine-type endopeptidase activity involved in apoptotic signaling pathway CASP9; CASP10; CASP2; CFLARA; CASP8; CFLAR; CASP8L1; CASP14
    death effector domain binding CFLARA; CASP10; NOL3; CASP8; CASP8L1; CFLAR; FADD
    protein binding LARS; LTBP2; STYX; KCNE1; EVL; CDC27; PHF19; PEX16; PTPRA; CDK20
    ubiquitin protein ligase binding DNAJA1; RANGAP1; CUL3; UBE2C; MC1R; ACTG1; PPARGC1A; TMEM173; DLG3; MAGEC2

    CASP10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP10 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP10.

    FADD; CASP8; CFLAR; RIOK3; XIAP

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