Recombinant Human CASP10 Protein, GST-Tagged

• Cat.No.: CASP10-0414H
• Product Overview: Human CASP10 full-length ORF (NP_001221.2, 1 a.a. - 479 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 81 kDa
• AA Sequence: MKSQGQHWYSSSDKNCKVSFREKLL IIDSNLGVQDVENLKFLCIGLVPNK KLEKSSSASDVFEHLLAEDLLSEED PFFLAELLYIIRQKKLLQHLNCTKE EVERLLPTRQRVSLFRNLLYELSEG IDSENLKDMIFLLKDSLPKTEMTSL SFLAFLEKQGKIDEDNLTCLEDLCK TVVPKLLRNIEKYKREKAIQIVTPP VDKEAESYQGEEELVSQTDVKTFLE ALPRAAVYRMNRNHRGLCVIVNNHS FTSLKDRQGTHKDAEILSHVFQWLG FTVHIHNNVTKVEMEMVLQKQKCNP AHADGDCFVFCILTHGRFGAVYSSD EALIPIREIMSHFTALQCPRLAEKP KLFFIQACQGEEIQPSVSIEADALN PEQAPTSLQDSIPAEADFLLGLATV PGYVSFRHVEEGSWYIQSLCNHLKK LVPRHEDILSILTAVNDDVSRRVDK QGTKKQMPQPAFTLRKKLVFPVPLD ALSL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CASP10 caspase 10, apoptosis-related cysteine peptidase [ Homo sapiens ]
• Official Symbol: CASP10
• Synonyms: CASP10; caspase 10, apoptosis-related cysteine peptidase; caspase 10, apoptosis related cysteine protease; caspase-10; MCH4; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; FAS-associated death domain protein interleukin-1B-converting enzyme 2; ALPS2; FLICE2
• Gene ID: 843
• mRNA Refseq: NM_001206524
• Protein Refseq: NP_001193453
• MIM: 601762
• UniProt ID: Q92851