CASP3

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CASP3

Official Full Name caspase 3, apoptosis-related cysteine peptidase
Background This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Synonyms CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; Apopain; CPP-32; EC 3.4.22.56; Yama; procaspase3; Cysteine protease CPP32; PARP cleavage protease; SREBP cleavage activity 1; Yama protein; caspase 3, apoptosis-related cysteine protease
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Wheat Germ
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • MBP
    • T7
    • Met
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CASP3-01H Recombinant Human CASP3 Protein, His-tagged E.coli His
    Human CASP3-1333H Recombinant Human CASP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CASP3-188H Recombinant Human CASP3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Casp3-771M Recombinant Mouse Casp3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CASP3-0421H Recombinant Human CASP3 Protein, GST-Tagged Wheat Germ GST
    Human CASP3-158H Recombinant Human CASP3 E.coli N/A
    Human CASP3-1642H Recombinant Human Caspase 3, Apoptosis-related Cysteine Peptidase E.coli N/A
    Human CASP3-192H Recombinant Human CASP3, Met&His-tagged E.coli Met/His
    Human CASP3-293H Recombinant Human CASP3 protein, His/MBP-tagged E.coli His/MBP
    Human CASP3-334H Recombinant Human CASP3 protein, GST-tagged Human Wheat Germ GST
    Human CASP3-342H Recombinant Human CASP3, His tagged E.coli His
    Human CASP3-36H Recombinant Human CASP3, His-tagged E.coli His
    Human CASP3-621H Recombinant Human CASP3 protein, His-tagged E.coli His
    Human CASP3-622H Recombinant Human CASP3 protein, His & T7-tagged E.coli His/T7
    Human CASP3-7838HCL Recombinant Human CASP3 293 Cell Lysate HEK293 N/A
    Human CASP3-7839HCL Recombinant Human CASP3 293 Cell Lysate HEK293 N/A
    Mouse Casp3-1641M Recombinant Mouse Caspase 3 E.coli N/A
    Mouse Casp3-1643M Recombinant Mouse Casp3 protein E.coli N/A
    Mouse Casp3-623M Recombinant Mouse Casp3 protein, His-tagged E.coli His
    Rat CASP3-1145R Recombinant Rat CASP3 Protein Mammalian Cell His
    Rat Casp3-624R Recombinant Rat Casp3 protein, His & T7-tagged E.coli His/T7
    Rat Casp3-625R Recombinant Rat Casp3 protein, His & T7-tagged E.coli His/T7
    Rat Casp3-748R Recombinant Rat Caspase 3, His-tagged E.coli His
    Cynomolgus Monkey CASP3-362C Recombinant Cynomolgus CASP3 Protein, His-tagged Mammalian Cell His
    Chicken CASP3-6290C Recombinant Chicken CASP3 Mammalian Cell His
    CBCRY39 Caspase-3 E.coli N/A

    CASP3 involved in several pathways and played different roles in them. We selected most pathways CASP3 participated on our site, such as MAPK signaling pathway, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PDGFAA; ATF4B1; NTRK1; STK4; PRKACA; FGF14; SRF; HSP70L; CDC42L; RAP1A
    p signaling pathway CASP3B; PMAIP1; EI24; TP53I3; TP53; PERP; CCNG2; GTSE1; FAS; CD82B
    Apoptosis IRAK4; TNFRSF1A; CASP2; BCL2A; BAXB; DFFB; BADB; RIPK1L; CTNNB2; PRKACBB
    Natural killer cell mediated cytotoxicity IFNA14; ULBP1; SH3BP2; PRKCA; LCP2; VAV2; PIK3CB; TNFRSF10D; Raet1c; PIK3R3
    TNF signaling pathway CASP8; NFKBIA; VEGFC; PTGS2; MAGI2; AKT1; MAPK3; CFLAR; AKT2; RPS6KA5
    Serotonergic synapse GNB1; GNG8; BRAF; GNAO1; TPH2; MAOB; HTR5A; CYP2D9; HTR3B; PLA2G4F
    Non-alcoholic fatty liver disease (NAFLD) PPARA; INSR; UQCRQ; NDUFB11; RXRA; INS1; IRS2; IKBKB; Il6ra; SDHC
    Alzheimers disease NDUFA2; CASP9; NDUFB10; SDHA; NDUFA10; NDUFB5; NDUFA1; MME; COX7C; COX7A2L
    Parkinsons disease NDUFV3; NDUFB3; CYCS; UBE1Y1; PRKACG; NDUFB6; NDUFC1; GNAI3; NDUFV1; COX7A1
    Amyotrophic lateral sclerosis (ALS) SOD1; Casp3; MAP3K5; CYCS; GPX1; TNFRSF1B; MAPK14; CAT; BID; MAP2K6
    Huntingtons disease COX8A; SDHA; COX7A1; UQCRC1; HDAC1; NDUFA4L2; NDUFA2; NDUFV3; NDUFB4; NDUFAB1
    Pertussis RHOA; Il23a; Il12b; TICAM2; CALM4; PYCARD; IRF8; IL6; Il23a; C1S; CALML5
    Legionellosis CASP9; BNIP3; VCP; PYCARD; HSPA1A; CLK1; CD14; EEF1G; HSPA8; CYCS
    Toxoplasmosis TRAF6; LAMA3; HLA-DQA2; IKBKB; MAP2K3; IFNGR2; BCL2; HSPA2; PPIF; HLA-DOA
    Amoebiasis LAMC3; CD1d1; TGFB1; CXCL1; IL1R1; PIK3R5; PLCB2; PIK3R3; COL1A2; CTSG
    Tuberculosis PPP3R1; LBP; CARD9; IL1B; HLA-DPB1; IFNA17; Itgam&Itgb2; CASP10; FCGR1A; ATP6V0C
    Hepatitis B BIRC5; TLR4; PRKCG; ATP6AP1; FAS; IFNA17; PIK3CG; Ifna15; IFNA21; CASP9
    Herpes simplex infection MAPK8A; IFNGR2; CSNK2A2; H2-AA; PER1B; UBE2R2; EIF2AK2; STAT1A; EEF1DA; CASP3A
    Pathways in cancer BMP2; CSF1R; FZD7; MAPK1; RASSF5; FGF13; MAP2K1; LPAR5; PDGFRA; BIRC2
    Viral carcinogenesis HDAC2; HLA-C; SP100; RBL2; HIST1H4J; SND1; ACTN4; SKP2; HIST2H4; GTF2H1
    Proteoglycans in cancer RRAS2; SLC9A1; Fasl; ITGA2; CD63; PRKCG; SDC4; FZD10; WNT3A; LUM
    MicroRNAs in cancer CYP24A1; WNT3; CDC25C; STAT3; TNXB; IRS2; FSCN1; ST14; VEGFA; RPTOR
    Colorectal cancer CASP9; MSH6; MSH3; TGFBR1; RAC1; TGFBR2; TP53; TCF7L2; TGFB1; PIK3CB
    Viral myocarditis ITGAL; HLA-DPA1; SGCB; CD80; HLA-DOA; HLA-DQA2; ABL1; HLA-B; SGCG; CAV1

    CASP3 has several biochemical functions, for example, aspartic-type endopeptidase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP3 itself. We selected most functions CASP3 had, and list some proteins which have the same functions with CASP3. You can find most of the proteins on our site.

    Function Related Protein
    aspartic-type endopeptidase activity SPPL3; PSEN1; CNTNAP5A; Casp3; Ren1; ANK2B; ASPRV1; DDI1; NOTS; PSEN2
    cyclin-dependent protein serine/threonine kinase inhibitor activity CDKN1D; CDKN1BB; HEXIM2; CDKN2D; HEXIM1; CDKN2B; CDKN1BA; CDKN2C; KAT2B; Casp3
    cysteine-type endopeptidase activity USP33; USP34; USP1; CASP7; CASP6L2; USP3; USP20; FMNL3; USP48; PDIA3
    cysteine-type endopeptidase activity involved in apoptotic process CASP8; Casp3; CLC
    cysteine-type endopeptidase activity involved in execution phase of apoptosis CASP3A; CASP6L2; CASP3B; CASP6L1; CASP7; CASP6; Casp3
    cysteine-type peptidase activity PIGK; USP12A; SENP7; Casp3; ATG4A; CASPC; OTULIN; CASP6L1; USP43A; CTSSB.1
    death receptor binding MYD88; RIPK1; BID; Fasl; NOL3; FASLG; CFLAR; Casp3; PRDM4; TNFSF15
    hydrolase activity DUSP8A; GBP3; DDX39; METAP2B; MBLAC2; GCH2; OTUD5A; CAPN3A; ABHD14A; Reln
    peptidase activity MPND; SPINT1A; ADAMTS7; PSMB11; USP43A; ADAMTS4; CTSL1B; CASPB; KLK1B24; MASP2
    phospholipase A2 activator activity PLAA; Casp3
    protease binding FN1; C10orf2; IL1R1; RNF139; ITGAV; FLOT2; TRP53; TIMP2A; XBP1; UBC
    protein binding EFCAB4B; KIAA1267; DLA; FAM83A; PPP2R3C; PEX12; RAD23A; PTPRB; PDP1; RPL5
    protein complex binding ABI1; DRD1A; CPD; COG2; CTSL2; RPTOR; LRRC16A; WRN; PAFAH1B1; MTAP1B

    CASP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP3.

    THAP11; Parp1; Hdgf; Pkm; Rps18; Acta2; Fam21; Nucks1; Htt

    Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
    Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).

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