CASP7 Protein, caspase 7, apoptosis-related cysteine peptidase

CASP7

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CASP7

Official Full Name caspase 7, apoptosis-related cysteine peptidase
Background This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.
Synonyms CASP7; Apoptotic protease Mch3; CASP 7; Caspase 7 subunit p11; Caspase 7 subunit p20; CMH1; ICE LAP3; ICE like apoptotic protease 3; OTTHUMP00000020510; OTTHUMP00000020511; OTTHUMP00000020512; OTTHUMP00000020513; OTTHUMP00000020514; Lice2 alpha/beta/gamma; caspase 7 isoform delta; caspase 7, apoptosis-related cysteine protease; caspase 7, apoptosis-related cysteine peptidase; MCH3; CMH-1; ICE-LAP3; EC 3.4.22.60; EC 3.4.22
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Casp7-772M Recombinant Mouse Casp7 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CASP7-0429H Recombinant Human CASP7 Protein E.coli N/A
    Human CASP7-0430H Recombinant Human CASP7 Protein, GST-Tagged Wheat Germ GST
    Human CASP7-602H Recombinant Human Caspase 7, Apoptosis-related Cysteine Peptidase E.coli N/A
    Human CASP7-680H Recombinant Human CASP7 Protein, His-tagged E.coli His
    Human CASP7-681H Recombinant Human CASP7 Protein, His-tagged E.coli His
    Human CASP7-7269H Recombinant Human CASP7, His tagged E.coli His
    Human CASP7-7832HCL Recombinant Human CASP7 293 Cell Lysate HEK293 N/A
    Human CASP7-7833HCL Recombinant Human CASP7 293 Cell Lysate HEK293 N/A
    Mouse CASP7-2755M Recombinant Mouse CASP7 Protein Mammalian Cell His
    Mouse Casp7-682M Recombinant Mouse Casp7 Protein, GST-tagged E.coli GST
    Mouse Casp7-683M Recombinant Mouse Casp7 Protein, His-tagged E.coli His
    Rat Casp7-684R Recombinant Rat Casp7 Protein, His-tagged E.coli His
    Zebrafish CASP7-2786Z Recombinant Zebrafish CASP7 Mammalian Cell His

    CASP7 involved in several pathways and played different roles in them. We selected most pathways CASP7 participated on our site, such as Apoptosis, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis IKBKG; CASP12; PRKAR2B; PPP3R1; TICAM1; CASP10; IRF1B; BID; PPP3CCB; CASP6
    TNF signaling pathway MMP14; ICAM1; CCL20; PIK3R5; MAP3K5; MAPK8; CASP7; CCL5; MAP2K1; LTA
    Non-alcoholic fatty liver disease (NAFLD) NDUFC1; UQCRC1; NDUFA2; COX7B; GSK3B; IL1B; FASLG; RAC1; COX7A1; NDUFS3
    Alzheimers disease ATP5J; NDUFS5; NDUFAB1; NDUFA13; ATP5G1; MME; UQCR10; PSEN1; UQCRC1; FADD
    Pertussis MAPK13; CFL2; IL-8; Casp3; NLRP3; MAPK3; IRF8; TRAF6; C2; C4BP
    Legionellosis CR1; HSPA6; SAR1B; HSPA8; TLR4; CASP7; PYCARD; C3; HBS1L; NAIP1

    CASP7 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP7 itself. We selected most functions CASP7 had, and list some proteins which have the same functions with CASP7. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase activity CASP9; CTSH; USP33; UCHL1; SFRP1; USP22; CTSZ; CTSLA; USP17L5; CTSL1B
    cysteine-type endopeptidase activity involved in execution phase of apoptosis CASP6L1; CASP3B; CASP3A; CASP6L2; Casp3; CASP6; CASP7
    cysteine-type peptidase activity DESI1; CLCA3; USP43; OTUD7B; CASP6L1; CASPBL; Ctsl; USP9; SOLH; CASP8L1
    protein binding FCER2; TOPORS; PRUNE; CD37; STX4; TCEB2; C10orf28; ESR2; PTPRG; RHPN1

    CASP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP7.

    XIAP; PAK2; SAT; SMPD1; BIRC2

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