casp7
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  • Official Full Name
  • caspase 7, apoptosis-related cysteine peptidase
  • Background
  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.
  • Synonyms
  • CASP7; Apoptotic protease Mch3; CASP 7; Caspase 7 subunit p11; Caspase 7 subunit p20; CMH1; ICE LAP3; ICE like apoptotic protease 3; OTTHUMP00000020510; OTTHUMP00000020511; OTTHUMP00000020512; OTTHUMP00000020513; OTTHUMP00000020514; Lice2 alpha/beta/gamma; caspase 7 isoform delta; caspase 7, apoptosis-related cysteine protease; caspase 7, apoptosis-related cysteine peptidase; MCH3; CMH-1; ICE-LAP3; EC 3.4.22.60; EC 3.4.22
Cat.#:CASP7-0429HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP7 Protein
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Cat.#:CASP7-0430HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CASP7 Protein, GST-Tagged
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Cat.#:CASP7-680HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP7 Protein, His-tagged
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Cat.#:CASP7-681HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP7 Protein, His-tagged
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Cat.#:CASP7-7269HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP7, His tagged
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Cat.#:CASP7-2755MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CASP7 Protein
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Cat.#:Casp7-682MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp7 Protein, GST-tagged
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Cat.#:Casp7-683MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp7 Protein, His-tagged
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Cat.#:Casp7-684RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Casp7 Protein, His-tagged
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Cat.#:CASP7-2786ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CASP7
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Cat.#:CASP7-602HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Caspase 7, Apoptosis-related Cysteine Peptidase
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Cat.#:CASP7-7832HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP7 293 Cell Lysate
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Cat.#:CASP7-7833HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP7 293 Cell Lysate
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Involved Pathway

CASP7 involved in several pathways and played different roles in them. We selected most pathways CASP7 participated on our site, such as Apoptosis, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
NMT1; PIK3R3B; BCL2; CAPN2L; DCC; BIRC5A; PRKAR2AA; PANK1A; RNF8; PIK3CD
TNF signaling pathway
MAP2K3; IL1B; CREB3L2; FOS; IL6; PIK3R2; CREB5; MAP2K6; MAPK11; CREB3L1
Non-alcoholic fatty liver disease (NAFLD)
COX7A2; IL1B; BAX; PIK3CG; SDHA; NDUFA2; IL1A; PPARA; ADIPOQ; INS2
Alzheimers disease
APOE; NDUFA11; NDUFB9; NDUFS6; ATP5F1; PPP3R2; COX6A2; COX6B1; COX4I2; FADD
Pertussis
Il23a; CALM4; NOS2; IL6; C1RA; IL12B; RELA; C4BPA; CFL2; CALM3
Legionellosis
BCL2L13; CD14; ITGAM; CASP1; ITGB2; BNIP3; HSPA6; NFKB2; TNF; CLK1

Protein Function

CASP7 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP7 itself. We selected most functions CASP7 had, and list some proteins which have the same functions with CASP7. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activity
Related Protein CFLARA; FMNL3; USP5; USP47; ESPL1; USP22; USP17L2; USP40; USP13; CASP3A
Function cysteine-type endopeptidase activity involved in execution phase of apoptosis
Related Protein CASP6L2; CASP6; CASP3A; CASP3B; Casp3; CASP6L1; CASP7
Function cysteine-type peptidase activity
Related Protein USP43; CLCA3; CASP3B; CTSC; CTSSA; CTLA2B; CAPN2; CASPC; ZRANB1B; OTUD7B
Function protein binding
Related Protein ITPR3; SRPK3; CYCS; DDRGK1; MUSK; NR1D1; PRKD3; FAM134C; CRADD; CLTB

Interacting Protein

CASP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP7.
XIAP; PAK2; SAT; SMPD1; BIRC2