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CCNC

Official Full Name

cyclin C
Overview

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

CCNC; cyclin C; cyclin-C; CycC; CCNC_HUMAN; hSRB11; OTTHUMP00000016897; SRB11 homolog;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Sf9 Insect Cell
Wheat Germ

Tag

GST
GST|His
His
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CDK8/CCNC-256H	Active Recombinant Human CDK8/CCNC, GST&His-tagged	Sf9 Insect Cell	GST/His		Inquiry
Human	CCNC-823H	Recombinant Human CCNC Protein, GST-His-tagged	E.coli	GST/His		Inquiry
Human	CCNC-0657H	Recombinant Human CCNC Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CCNC-07H	Recombinant Human Cyclin C	E.coli	N/A		Inquiry
Human	CCNC-08H	Recombinant Human CCNC, His tagged	E.coli	His		Inquiry
Human	CCNC-27518TH	Recombinant Human CCNC, His-tagged	E.coli	His		$786 / 100µg
Human	CCNC-10859H	Recombinant Human CCNC, His-tagged	E.coli	His	1-283a.a.	$319 / 25ug
Human	CCNC-7714HCL	Recombinant Human CCNC 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CCNC-7715HCL	Recombinant Human CCNC 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CCNC-2965HF	Recombinant Full Length Human CCNC Protein, GST-tagged	In Vitro Cell Free System	GST	283 amino acids	Inquiry
Zebrafish	CCNC-10317Z	Recombinant Zebrafish CCNC	Mammalian Cell	His		Inquiry
Chicken	CCNC-4033C	Recombinant Chicken CCNC	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CCNC involved in several pathways and played different roles in them. We selected most pathways CCNC participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	CDK8;JAG1;HEY2;HEYL;HDAC6;HDAC5;CCNC;ADAM10;HEY1
Constitutive Signaling by NOTCH1 PEST Domain Mutants	HDAC5;HDAC6;MIB1;JAG1;CCNC;CDK8;JAG2;HEY1;HEYL
Developmental Biology	KBTBD7;CLTA;TCF3B;KALRNB;DUSP10;TCF12;MED15;ANK2B;MED6
Disease	NUPL2;DERL2;AP1M2;OPN1SW;NMT2;SUPT4H1;VPS37A;MTRR;TIRAP
Diseases of signal transduction	FGFR1OP2;CTBP1;FGFR1OP;KREMEN1;HEYL;MYO18A;TRIM24;RBP1;KREMEN2
Fatty acid, triacylglycerol, and ketone body metabolism	STIL;AGPAT2;CPT1B;MED20;SLC25A20;MED15;ACOT13;SREBF2;MED31
Gene Expression	RRN3;ZNF223;TRMT6;CCNT2A;RRP8;ZFP36L1A;PAIP1;C2orf49;ESR2B
Generic Transcription Pathway	ZFP28;TUBB3;ZNF620;ZNF625;FAM36A;ZNF613;MED6;ZNF483;KRBOX4

CCNC has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase regulator activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNC itself. We selected most functions CCNC had, and list some proteins which have the same functions with CCNC. You can find most of the proteins on our site.

Function	Related Protein
cyclin-dependent protein serine/threonine kinase regulator activity	CCNL1B;CCNL1;CCNT1;CCNL2;CCNT2A;CCND1;CDK4;CKS2;CCNE1
protein binding	PPM1A;CTAG2;DNAJA2;KRTAP9-2;ATP6V1E1;NSMCE1;SEC63;RUFY3;MARCKSL1
ubiquitin protein ligase activity	MDM2;UBE2NB;TRIP12;LTN1;ANAPC11;STUB1;SIAH2L;RNF220;PDZD4

CCNC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNC here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNC.

CDK8