ccnh
Share
  • Official Full Name
  • cyclin H
  • Background
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.
  • Synonyms
  • CCNH; cyclin H; cyclin-H; CAK complex subunit; CDK activating kinase complex subunit; cyclin dependent kinase activating kinase complex subunit; MO15 associated protein; p34; p37; MO15-associated protein; CDK-activating kinase complex subunit; cyclin-depe
Cat.#:CCNH-0672HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCNH Protein, GST-Tagged
+Inquiry
Cat.#:CCNH-10868HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCNH, GST-tagged
+Inquiry
Cat.#:CCNH-128HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CCNH, His-tagged
+Inquiry
Cat.#:CCNH-27015THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCNH, His-tagged
+Inquiry
Cat.#:CCNH-28153THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCNH
+Inquiry
Cat.#:CCNH-31758THTag:His
Source (Host):Species:Human
Product nameRecombinant Human CDK7, His-tagged
+Inquiry
Cat.#:CCNH-2997MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCNH Protein
+Inquiry
Cat.#:CCNH-1225RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCNH Protein
+Inquiry
Cat.#:CCNH-376CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CCNH Protein, His-tagged
+Inquiry
Cat.#:CCNH-701RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCNH Protein, His-tagged
+Inquiry
Cat.#:CCNH-2143ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CCNH
+Inquiry
Cat.#:CCNH-627HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cyclin H, His-tagged
+Inquiry
Cat.#:CCNH-7705HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCNH 293 Cell Lysate
+Inquiry
Cat.#:CDK7 & CCNH & MNAT1-539HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDK7 & CCNH & MNAT1 cell lysate
+Inquiry

Involved Pathway

CCNH involved in several pathways and played different roles in them. We selected most pathways CCNH participated on our site, such as Basal transcription factors, Nucleotide excision repair, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNH were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Basal transcription factors
TBP; GTF2H3; GTF2F1; GTF2A2; GTF2IRD1; GTF2A1; TAF5L; GTF2F2B; GTF2F2A; GTF2H4
Nucleotide excision repair
RAD23A; ERCC3; GTF2H2C_2; COPS4; YY1; GTF2H2; GTF2H4; COPS8; INO80; COPS7B
Cell cycle
TGFB2; PDS5A; MCM9; MCM7; BARD1; KIF20A; CSNK2B; CCP110; CDC6; FZR1A

Protein Function

CCNH has several biochemical functions, for example, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNH itself. We selected most functions CCNH had, and list some proteins which have the same functions with CCNH. You can find most of the proteins on our site.
Function
Related Protein
Function serine-type endopeptidase inhibitor activity
Related Protein SERPINF2B; TFPI2; WFDC6B; PCSK1N; SERPINB3C; AMBP; SERPINC1; SERPINI1; ITIH6; SPINT2

Interacting Protein

CCNH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNH here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNH.
GOLGA2; CDK2; CDK7; SSSCA1; PSMA1

CCNH Related Articles

Du, X; Li, YM; et al. Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cells. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:1559-1564(2014).
Park, KS; Bayles, I; et al. Transcription Elongation Factor ELL2 Drives Ig Secretory-Specific mRNA Production and the Unfolded Protein Response. JOURNAL OF IMMUNOLOGY 193:4663-4674(2014).