CCR8
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Official Full Name
chemokine (C-C motif) receptor 8
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Overview
CCR8 (C-C chemokine receptor 8, CKR-L1, cy6) is a member of the beta-chemokine receptor family that is preferentially expressed in the thymus. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites -
Synonyms
CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor;
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- Cynomolgus
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- Cynomolgus Monkey
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- Rhesus macaque
- E.coli
- E.coli expression system
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- Wheat Germ
- GST
- hFc tag
- His
- His (Fc)
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- SUMO
- mFc tag
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CCR8 Related Articles
- CCR8 Related Gene Family
- CCR8 Related Research Area
CCR8 involved in several pathways and played different roles in them. We selected most pathways CCR8 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Chemokine receptors bind chemokines | ACKR4;CCBP2;CXCL13;CCL19A.2;CCR6;CCRL2;CXCR7B;CCL35.2;CX3CR1 |
Chemokine signaling pathway | PARD3;PRKACG;CCL6;CCR6;GNAI3;PPBP;RHOA;CCR8;PIK3CG |
Class A/1 (Rhodopsin-like receptors) | CCL35.2;OPN4A;GAL;CNR2;PROKR1A;CCR6;FPR-RS3;KISS1;ADORA1 |
Cytokine-cytokine receptor interaction | GM2002;BMP2;NGFRB;IL11RA;GM2506;IL6;TNFRSF18;IFNA12;CCR1L1 |
G alpha (i) signalling events | TAS2R16;ADORA1;APLNR;CCL27;PENKA;ANXA1;RGS21;RLN3A;AGT |
GPCR downstream signaling | ARHGEF9;RGS11;KALRNB;RGS14;APPB;GPR68;SSTR5;NPS;LPAR2A |
GPCR ligand binding | PTH2;ADCYAP1;OPN5;GCGB;PNOCB;OPN1LW2;GCGA;CHRM5;CD97 |
GPCRs, Class A Rhodopsin-like | SSTR1;CHRM4;CCR3;CMKLR1;LTB4R;HRH3;DRD4;OPN1SW;ACKR4 |
CCR8 has several biochemical functions, for example, C-C chemokine receptor activity, chemokine receptor activity, coreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR8 itself. We selected most functions CCR8 had, and list some proteins which have the same functions with CCR8. You can find most of the proteins on our site.
Function | Related Protein |
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C-C chemokine receptor activity | CCR1;CCR6A;CCR9;CCR10;CCR7;CCBP2;CCR6;CCR3;CCR5 |
chemokine receptor activity | XCR1;CXCR4A;GPR17;CXCR1;RGRB;CCR9;ACKR3B;CCR5;CCR1 |
coreceptor activity | PVRL2;ACVR2A;CCR5;RAMP1;RGMB;LRP5;CD4;LY96;CXCR4 |
CCR8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR8.
- Q&As
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Q&As (7)
Ask a questionC-C chemokine receptor type 8 (CCR8) primarily functions in the immune system, playing a role in immune responses and cell migration.
CCR8 plays a role in influencing the balance between immune tolerance and inflammation through its impact on T cell function.
Dysregulation or abnormal expression of CCR8 is associated with conditions like allergic diseases, autoimmune disorders, and certain cancers.
CCR8 is predominantly expressed in certain immune cells, including regulatory T cells (Tregs) and certain subsets of T lymphocytes.
CCR8 contributes to the regulation of immune responses and cell migration by responding to specific chemokines in the microenvironment.
Specific chemokines, such as CCL1, bind to CCR8, influencing immune modulation and cell trafficking.
There are potential therapeutic implications related to CCR8 in immune-related disorders, making it a target of interest for drug development.
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