CD59 Protein, CD59 molecule, complement regulatory protein

CD59

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CD59

Official Full Name CD59 molecule, complement regulatory protein
Background This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Synonyms CD59; CD59 molecule, complement regulatory protein; 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20; CD59 glycoprotein; protectin; 1F5 antigen; MEM43 antigen; Ly-6-like protein; T cell-activating protein; human leukocyte antigen MIC11; lymphocytic antigen CD59/MEM43; 20 kDa homologous restriction factor; membrane inhibitor of reactive lysis; membrane attack complex inhibition factor; membrane attack complex (MAC) inhibition factor; surface anitgen recognized by monoclonal antibody 16.3A5; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344);
    • Species :
    • Cynomolgus Monkey
    • Human
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • S
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD59-0836H Recombinant Human CD59 Protein, GST-Tagged Wheat Germ GST
    Human CD59-15902H Recombinant Human CD59, His-tagged E.coli His
    Human CD59-1600H Recombinant Human CD59, His-tagged NS0 His
    Human CD59-1968HCL Recombinant Human CD59 cell lysate Human Cell N/A
    Human CD59-3116H Recombinant Human CD59 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CD59-3977H Recombinant Human CD59, His tagged Human Cell His
    Human CD59-76H Recombinant Human CD59 protein, T7/His-tagged E.coli T7/His
    Rat CD59-1260R Recombinant Rat CD59 Protein Mammalian Cell His
    Rat CD59-1365RCL Recombinant Rat CD59 cell lysate Human Cell N/A
    Rat Cd59-6831R Recombinant Rat Cd59 protein, His & S-tagged E.coli His/S
    Rat Cd59-8764R Recombinant Rat Cd59, Fc tagged Human Cell Fc
    Rat Cd59-8765R Recombinant Rat Cd59, His tagged Human Cell His
    Cynomolgus Monkey CD59-1019CCL Recombinant Cynomolgus CD59 cell lysate Human Cell N/A
    Cynomolgus Monkey CD59-392C Recombinant Cynomolgus CD59 Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey CD59-97C Recombinant Cynomolgus CD59, His tagged Human Cell Fc/His
    Rhesus monkey CD59-6833R Recombinant Rhesus monkey CD59 protein, His & S-tagged E.coli His/S
    Rhesus Macaque CD59-746R Recombinant Rhesus monkey CD59 Protein, His-tagged Mammalian Cell His
    Rabbit CD59-6832R Recombinant Rabbit CD59 protein, His & S-tagged E.coli His/S
    Pig CD59-6830P Recombinant Pig CD59 protein, His & T7-tagged E.coli His/T7

    CD59 involved in several pathways and played different roles in them. We selected most pathways CD59 participated on our site, such as Complement and coagulation cascades, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD59 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades MASP1; C1QC; C9; C7; CR1; MASP2; C3AR1; C2; F12; F13A1
    Hematopoietic cell lineage IL1R2; CD33; CSF3R; CD4; ITGA3; FCGR1; CD14; IL6R; CD2; MS4A1

    CD59 has several biochemical functions, for example, complement binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD59 itself. We selected most functions CD59 had, and list some proteins which have the same functions with CD59. You can find most of the proteins on our site.

    Function Related Protein
    complement binding C8A; CR2; CFB; CD59; C8G; CD46
    protein binding HOXB7; THAP3; ARIH2; SLC14A2; RAB4B; ZNF550; ISOC1; C1QBP; TEAD2; SOCS5

    CD59 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD59 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD59.

    TMED10; TMED2; C; EGFR; ganglioside_gm1; SMAD4; q7cgd4_yerpe; b3xyc5_sollc; ATP6AP2; CFTR

    Shi, H; Williams, J; et al. Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. APOPTOSIS 20:433-443(2015).
    Ahmed, S; Kemp, MW; et al. Comparison of Complement Activity in Adult and Preterm Sheep Serum. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 73:232-241(2015).

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