• Official Full Name
  • CD59 molecule, complement regulatory protein
  • Background
  • This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CD59; CD59 molecule, complement regulatory protein; 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20; CD59 glycoprotein; protectin; 1F5 antigen; MEM43 antigen; Ly-6-like protein; T cell-activating protein; human leukocyte antigen MIC11; lymphocytic antigen CD59/MEM43; 20 kDa homologous restriction factor; membrane inhibitor of reactive lysis; membrane attack complex inhibition factor; membrane attack complex (MAC) inhibition factor; surface anitgen recognized by monoclonal antibody 16.3A5; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344);
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD59 Protein, GST-Tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD59 Protein, MYC/DDK-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD59, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human CD59, His-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD59, His tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD59 protein, T7/His-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CD59 Protein
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cd59 protein, His & S-tagged
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd59, Fc tagged
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd59, His tagged
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD59 Protein, His-tagged
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD59, His tagged
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey CD59 protein, His & S-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CD59 Protein, His-tagged
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit CD59 protein, His & S-tagged
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CD59 protein, His & T7-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD59 cell lysate
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CD59 cell lysate
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD59 cell lysate

Involved Pathway

CD59 involved in several pathways and played different roles in them. We selected most pathways CD59 participated on our site, such as Complement and coagulation cascades, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD59 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
CFD; CD59; C9; PLAUR; Hc; C8G; F3; A2M; CFH; FGA
Hematopoietic cell lineage

Protein Function

CD59 has several biochemical functions, for example, complement binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD59 itself. We selected most functions CD59 had, and list some proteins which have the same functions with CD59. You can find most of the proteins on our site.
Related Protein
Function complement binding
Related Protein CD46; C8G; CR2; C8A; CFB; CD59
Function protein binding
Related Protein ASAP3; NFU1; UBE2L3; PAK3; FBXO28; PLAA; OLFM3; TRAM2; OLFM1; CA4

Interacting Protein

CD59 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD59 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD59.
TMED10; TMED2; C; EGFR; ganglioside_gm1; SMAD4; q7cgd4_yerpe; b3xyc5_sollc; ATP6AP2; CFTR

CD59 Related Articles

Shi, H; Williams, J; et al. Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. APOPTOSIS 20:433-443(2015).
Ahmed, S; Kemp, MW; et al. Comparison of Complement Activity in Adult and Preterm Sheep Serum. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 73:232-241(2015).