CDC6

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CDC6

Official Full Name cell division cycle 6 homolog
Background The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the;initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It;localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The;subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks.;Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional;control mechanism involving E2F proteins.
Synonyms CDC6; cell division cycle 6 homolog (S. cerevisiae); CDC6 (cell division cycle 6, S. cerevisiae) homolog , CDC6 cell division cycle 6 homolog (S. cerevisiae) , CDC18L; cell division control protein 6 homolog; p62(cdc6); CDC6-related protein; cdc18-relate
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDC6-022H Recombinant Human CDC6 Protein, His-tagged E.coli His
    Human CDC6-11018H Recombinant Human CDC6, GST-tagged E.coli GST
    Human CDC6-7647HCL Recombinant Human CDC6 293 Cell Lysate HEK293 N/A
    Human CDC6-93H Recombinant Human cell division cycle 6 homolog (S. cerevisiae) E.coli N/A
    Human CDC6-96H Recombinant Human CDC6, GST-tagged Wheat Germ GST
    Mouse CDC6-3152M Recombinant Mouse CDC6 Protein Mammalian Cell His
    Zebrafish CDC6-6781Z Recombinant Zebrafish CDC6 Mammalian Cell His

    CDC6 involved in several pathways and played different roles in them. We selected most pathways CDC6 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle CCND2A; YWHAE; CDKN2B; MIS12; PCM1; ORC1; BUB1B; CDK1; YWHAE1; NDEL1B

    CDC6 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC6 itself. We selected most functions CDC6 had, and list some proteins which have the same functions with CDC6. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PMS1; NLRC4; RIPK3; ULK3; TWF2; DAPK2; SWAP70; MAPK14; UBA2; PIK3CG
    kinase binding SP100; SNAI1; EMP2; RB1; CEBPB; SIT1; CHIA; BARD1; WWC3; MOBKL1A
    nucleotide binding MATR3L; PKN1B; EK1; NXF3; PRKACBB; HPRT1; EIF4A1B; GNA15.4; GNA11B; RAC1B
    protein binding HNRNPH1; SPSB4; PDIA2; POU2F3; YES1; RAD52; C3orf62; THG1L; SSR1; MEPE

    CDC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC6.

    CDKN1A; CDT1; ORC5; CDK4; MCM3; CDKN2A; MCM2; CDK6; ORC1; ORC2; MCM10; ORC3; ORC6; Cdc6; EBNA1; UBB; MCM7

    Di Paola, D; Rampakakis, E; et al. Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformation. NUCLEIC ACIDS RESEARCH 38:2314-2331(2010).
    Buechler, S; et al. Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer. BMC CANCER 9:-(2009).

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