cdc6
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  • Official Full Name
  • cell division cycle 6 homolog
  • Background
  • The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the;initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It;localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The;subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks.;Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional;control mechanism involving E2F proteins.
  • Synonyms
  • CDC6; cell division cycle 6 homolog (S. cerevisiae); CDC6 (cell division cycle 6, S. cerevisiae) homolog , CDC6 cell division cycle 6 homolog (S. cerevisiae) , CDC18L; cell division control protein 6 homolog; p62(cdc6); CDC6-related protein; cdc18-relate
Cat.#:CDC6-022HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC6 Protein, His-tagged
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Cat.#:CDC6-11018HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC6, GST-tagged
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Cat.#:CDC6-93HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human cell division cycle 6 homolog (S. cerevisiae)
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Cat.#:CDC6-96HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CDC6, GST-tagged
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Cat.#:CDC6-3152MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDC6 Protein
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Cat.#:CDC6-6781ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDC6
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Cat.#:CDC6-7647HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CDC6 293 Cell Lysate
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Involved Pathway

CDC6 involved in several pathways and played different roles in them. We selected most pathways CDC6 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
SPC25; CEP57; ORC3; HIST4H4; ANAPC11; NEK2; E2F5; DIDO1; ANKLE2; CDC14AA

Protein Function

CDC6 has several biochemical functions, for example, ATP binding, kinase binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC6 itself. We selected most functions CDC6 had, and list some proteins which have the same functions with CDC6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NEK4; PI4K2A; OASL1; CAMKK2; MAP3K10; UBE2Z; ITGB1BP3; TTK; CDK9; CSK
Function kinase binding
Related Protein WWC1; JAKMIP1; HPCA; SIT1; JAKMIP2; MIDN; TENC1; DGKQ; RASGRP3; PER3
Function nucleotide binding
Related Protein CHD8; PABPC4; RBM24B; TINAG; ATP2A1L; ERBB3B; NCL; UBE2QL1; HPRT1; CLCN4-2
Function protein binding
Related Protein GRIN3A; DOK4; GAK; SEC61G; Arid4b; OFD1; JMJD6; HER5; VEGFAA; CBLL1

Interacting Protein

CDC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC6.
CDKN1A; CDT1; ORC5; CDK4; MCM3; CDKN2A; MCM2; CDK6; ORC1; ORC2; MCM10; ORC3; ORC6; Cdc6; EBNA1; UBB; MCM7

CDC6 Related Articles

Di Paola, D; Rampakakis, E; et al. Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformation. NUCLEIC ACIDS RESEARCH 38:2314-2331(2010).
Buechler, S; et al. Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer. BMC CANCER 9:-(2009).