Recombinant Human CDC6, GST-tagged CDC6-96H

Recombinant Human CDC6, GST-tagged

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Cat.No. : CDC6-96H Optional Service: Optional requirements on this protein
Product Overview : Recombinant human CDC6 encoding human CDC6 partial ORF (434a.a. - 533 a.a.) produced in in vitro wheat germ expression system, was fuseda GST-tag at N-terminal.
Description : The protein encoded by this gene is highlysimilar to Saccharomyces cerevisiae Cdc6, a protein essential for theinitiation of DNA replication. This protein functions as a regulator at theearly steps of DNA replication. It localizes in cell nucleus during cell cyleG1, but translocates to the cytoplasm at the start of S phase. Thesubcellular translocation of this protein during cell cyle is regulatedthrough its phosphorylation by Cdks. Transcription of this protein wasreported to be regulated in response to mitogenic signals throughtranscriptional control mechanism involving E2F proteins.
Source : wheat germ
Sequence : ISQVISEVDG NRMTLSQEGA QDSFPLQQKI LVCSLMLLIR QLKIKEVTLG KLYEAYSKVC RKQQVAAVDQ SECLSLSGLL EARGILGLKR NKETRLTKVF
Purification : GlutathioneSepharose 4 Fast Flow
Molecular Weight : 36.74 kDa
Applications : ELISA;WB
StorageBuffer : 50 mM Tris-HCI, 10mM reduced Glutathione, pH8.0 in the elution buffer.
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
CrystalStructure of CDC6p from P. aerophilum. :

Gene Name : CDC6cell division cycle 6 homolog (S. cerevisiae) [ Homo sapiens ]
Official Symbol : CDC6
Synonyms : CDC6; cell division cycle 6 homolog (S. cerevisiae);CDC18L; HsCDC6; HsCDC18; CDC6 (cell division cycle 6, S. cerevisiae) homolog;CDC6 cell division cycle 6 homolog (S. cerevisiae); Cell division controlprotein 6 homolog; p62(cdc6); CDC18 (cell division cycle 18, S.pombe,homolog)-like; homolog; CDC6 cell division cycle 6 homo; CDC6-relatedprotein; cell division cycle 6 homolog (S. cerevisiae); cell division cycle 6protein
Gene ID : 990
mRNA Refseq : NM_001254
Protein Refseq : NP_001245
MIM : 602627
UniProt ID : Q99741
Chromosome Location : 17q21.3
Pathway : Activation of ATRin response to replication stress; Cell Cycle, Mitotic; DNA Replication
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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