CDH6
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Official Full Name
cadherin 6, type 2, K-cadherin (fetal kidney) -
Overview
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. -
Synonyms
CDH6;cadherin 6, type 2, K-cadherin (fetal kidney);cadherin-6;K Cadherin;CAD6;KCAD;FLJ14176;DKFZp564N1116
Recombinant Proteins
- Human
- Mouse
- Cynomolgus/Rhesus macaque
- Rat
- Chicken
- Zebrafish
- Cynomolgus
- Mus musculus
- HEK293
- E.coli
- Mammalian Cells
- Wheat Germ
- Human Cells
- In Vitro Cell Free System
- His
- GST
- Fc
- T7
- Non
- Avi
Involved Pathway
CDH6 involved in several pathways and played different roles in them. We selected most pathways CDH6 participated on our site, such as Adherens junctions interactions,Cell junction organization,Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell junction organization | CADM2B,RSU1,CDH12,LIMS1,CTNND1,PLEC,PLECA,CLDN3,F11R.2,CLDN20 |
| Cell-Cell communication | DSCAMA,CDH7,DSCAML1,INADL,JUP,CD151,CDH18,CDH10A,CDH12,PVRL1A |
| Cell-cell junction organization | CDH8,CDH24,CLDN23,CDH9,CDH18A,CLDN7,CDH10A,CDH12,CLDN16,ANG |
| Adherens junctions interactions | CDH12,PVRL1A,CDH18A,CTNNB2,CDH3,CTNNB1,CDH24,CDH11,JUP,CDH10 |
| Neural Crest Differentiation | TCF4,ZIC1,OLIG3,CDH7,GBX2,PMP22,DMBX1,ASCL1,SOX5,LHX2 |
Protein Function
CDH6 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH6 itself. We selected most functions CDH6 had, and list some proteins which have the same functions with CDH6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | FKBP9,DLL4,PCDH2AB1,EHD3,PCDHB2,S100A1,FBLN2,LTBP4,CIB4,RASGRP4 |
Interacting Protein
CDH6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH6.
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References
- Butler, MG; Rafi, SK; et al. Whole Exome Sequencing in Females with Autism Implicates Novel and Candidate Genes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16:1312-1335(2015).
- Clay, MR; Halloran, MC; et al. Cadherin 6 promotes neural crest cell detachment via F-actin regulation and influences active Rho distribution during epithelial-to-mesenchymal transition. DEVELOPMENT 141:2506-2515(2014).
