CDK12 Protein, cyclin-dependent kinase 12

CDK12

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CDK12

Official Full Name cyclin-dependent kinase 12
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Synonyms CRK7; CRKR; CRKRS; hCDK12; KIAA0904; cyclin-dependent kinase 12; OTTHUMP00000164282; CDC2-related protein kinase 7; cell division protein kinase 12; Cdc2-related kinase, arginine/serine-rich; cell division cycle 2-related protein kinase 7
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDK12-11H Recombinant Human CDK2 Protein, GST-tagged Insect Cell GST
    Human CDK12-16H Recombinant Human CDK12 protein, GST-tagged Insect Cell GST
    Human CDK12-1888H Recombinant Human CDK12 Protein, GST-tagged Wheat Germ GST
    Mouse CDK12-3192M Recombinant Mouse CDK12 Protein Mammalian Cell His
    Rat CDK12-1301R Recombinant Rat CDK12 Protein Mammalian Cell His
    Rhesus Macaque CDK12-780R Recombinant Rhesus monkey CDK12 Protein, His-tagged Mammalian Cell His

    CDK12 involved in several pathways and played different roles in them. We selected most pathways CDK12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    CDK12 has several biochemical functions, for example, ATP binding, RNA polymerase II carboxy-terminal domain kinase activity, cyclin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK12 itself. We selected most functions CDK12 had, and list some proteins which have the same functions with CDK12. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PRKACA; EPHB1; MLH3; CCT3; PFKL; NLRP4; ACTR2; ORC1L; RHOBTB3; ACVR2AA
    RNA polymerase II carboxy-terminal domain kinase activity CDK9; MAPK1; CDK12; CDK13; CDK8; CCNK; CDK7; CDK1
    cyclin binding CDK2; CDK14; INCA1; CDKN1A; CDK12; PFTK1; HDAC3; PTCH1; MDFIC; CDK5RAP3
    cyclin-dependent protein serine/threonine kinase activity CDK20; MOK; CDK18; CDK6; STK30; CDK11B; CDK5R1; CDK7; CDK3; CCNK
    kinase activity GM4922; CDK5R1B; PKLR; PKM2; PIP5K1AA; ADKB; PHKG1B; PLK1; NLK1; CCL3
    nucleotide binding ARL4CA; NXF1; ATP9B; HHATL; MAP2K2A; EPHA4B; MYEF2; RAC3B; NT5C1BA; MXA
    protein kinase activity PHKG1B; MAP4K5; MAP4K6; MMD; CSNK1DB; CAMK1DB; CDK1; NPRL2; NEK4; SLKA
    protein serine/threonine kinase activity MAPK12; RPS6KA1; MAP2K3; STK38; IRAK1; MAP3K9; SYK; RPS6KAL; BMPR1A; PRKCBA
    transferase activity PRKCBP1L; PLAUA; ST3GAL3A; UGGT1; SMOK2B; TRIO; CMPK; GGT1A; CEPT1B; ZDHHC21

    CDK12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK12.

    Ywhae

    Rudrabhatla, P; Utreras, E; et al. Regulation of Sox6 by Cyclin Dependent Kinase 5 in Brain. PLOS ONE 9:-(2014).
    Hattori, T; Uchida, C; et al. Distinct and Site-Specific Phosphorylation of the Retinoblastoma Protein at Serine 612 in Differentiated Cells. PLOS ONE 9:-(2014).

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