Recombinant Human CDK12 Protein, GST-tagged

• Cat.No.: CDK12-11H
• Product Overview: Recombinant human CDK12 (658-end) /Cyclin K complex was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins.

Specification

• Description: CDK12 forms a protein complex with cyclin K and this complex acts at the level of RNA polymerase II (RNAPII) to regulate expression of long complex genes, several of which play a role in DNA maintenance and repair. CDK12 is highly expressed in adult liver, kidney, testis, ovary, spinal cord and within specific adult brain regions with the highest expression being detected in cerebellum and caudate nucleus. CYCK-CDK12 and CYCK-CDK13 complexes show unique function with the CYCK-CDK12 playing a role in maintenance of genomic stability.
• Source: Insect cells
• Species: Human
• Tag: GST
• Molecular Mass: CDK12 ~135kDa and CyclinK ~67kDa
• Purity: > 80%
• Applications: WB
• Stability: One year at -70 centigrade from data of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: >0.1 μg/μL

Gene Information

• Gene Name: CDK12 cyclin dependent kinase 12 [ Homo sapiens (human) ]
• Official Symbol: CDK12
• Synonyms: CDK12; cyclin dependent kinase 12; CRK7; CRKR; CRKRS; cyclin-dependent kinase 12; CDC2-related protein kinase 7; Cdc2-related kinase, arginine/serine-rich; cell division cycle 2-related protein kinase 7; cell division protein kinase 12; EC 2.7.11.22; EC 2.7.11.23
• Gene ID: 51755
• mRNA Refseq: NM_016507
• Protein Refseq: NP_057591
• MIM: 615514
• UniProt ID: Q9NYV4

Reviews

07/08/2019

The CDK12 Protein's superior stability and functional performance render it an indispensable tool for a wide range of scientific investigations.

06/02/2019

They have proven to be a timely and reliable resource, readily addressing any concerns or challenges that arise during my research.

07/11/2018

Their expertise and assistance have been invaluable in troubleshooting and providing insightful solutions, greatly enhancing the progress of my experiments.

Q&As

How is CDK12 protein expression related to cancer progression and prognosis?

Higher expression of CDK12 has been associated with more aggressive cancer phenotypes and poorer prognosis.

What are the potential biomarker implications of CDK12 expression in cancer patients?

CDK12 expression may serve as a prognostic and predictive biomarker for cancer patients, influencing treatment decisions.

How does CDK12 dysregulation impact the sensitivity of cancer cells to chemotherapy and targeted therapies?

CDK12 dysregulation can impact the sensitivity of cancer cells to chemotherapy and targeted therapies, affecting treatment response.

Are there any implications of CDK12 mutations in cancer susceptibility and therapy response?

CDK12 mutations may impact cancer susceptibility and therapy response, influencing the clinical management of patients.

In which cancer types has CDK12 dysregulation been implicated?

CDK12 dysregulation has been implicated in prostate cancer, ovarian cancer, breast cancer, and other solid tumors.