cdk6
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  • Official Full Name
  • cyclin-dependent kinase 6
  • Background
  • The cyclin-dependent kinases form complexes with their cyclin partners and with CDK inhibitors. CDK6 and CDK4 associate with the D-type cyclins and target the retinoblastoma protein, allowing passage through the G1/S phase restriction point (1). CDK6/cycl
  • Synonyms
  • CDK6; cyclin-dependent kinase 6; PLSTIRE; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE; MGC59692
Cat.#:CDK6/CCND1-277HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK6/CCND1, His-tagged, GST-tagged, Active
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Cat.#:CDK6/CCND3-278HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK6/CCND3, His-tagged, Active
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Cat.#:CDK6-1028HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDK6 Protein, GST-Tagged
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Cat.#:CDK6-1032HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CDK6 Protein, GST-Tagged
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Cat.#:CDK6-27908THTag:His
Source (Host):Species:Human
Product nameRecombinant Human CDK6, His-tagged
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Cat.#:CDK6-788RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDK6 Protein, His-tagged
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Cat.#:CDK6-1791CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDK6
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Cat.#:CDK6-7274ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDK6
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Cat.#:CDK6-1002HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Cyclin-Dependent Kinase 6, His-tagged
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Cat.#:CDK6-1537HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK6, Unactive, His-tagged
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Cat.#:CDK6-7622HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CDK6 293 Cell Lysate
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Involved Pathway

CDK6 involved in several pathways and played different roles in them. We selected most pathways CDK6 participated on our site, such as B Cell Receptor Signaling Pathway, C-MYB transcription factor network, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
B Cell Receptor Signaling Pathway
HRAS; CD22; CR2; LILRB3; VAV2; ACTR2; BCL2L11; PILRB; IKBKG; IGHM
C-MYB transcription factor network
SKI; SLC25A3; PPID; ADA; CDK6; PRTN3; CLTA; TOM1; CBX4; PIAS3
Cell Cycle
FZR1; CLSPN; PHF8; RAD9A; CDK2; PDS5B; ARPP19A; GORASP1; EP300; CDC45
Cell Cycle, Mitotic
CLIP1; TMEM188; AURKB; MCPH1; DNA2; ARPP19A; SETB; ODF2; OFD1; LIN52
Cellular Senescence
BMI1A; KDM6B; MAPKAPK2B; RAD50; IGFBP7; CBX8B; CDKN2C; EED; RNF2; RBB4L
Cellular responses to stress
TINF2; AGO1; HIST4H4; SUZ12A; EPAS1B; MINK1; HMGA1B; LAMTOR2; PRDX3; HIST1H1C
Chronic myeloid leukemia
MAP2K2; PIK3CD; ARAF; PIK3CB; PIK3R5; SMAD4; MECOM; RB1; STAT5A; PTPN11

Protein Function

CDK6 has several biochemical functions, for example, ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK6 itself. We selected most functions CDK6 had, and list some proteins which have the same functions with CDK6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein HK3; ATP2A2B; RIPK1; EPHB2; GATC; BLM; ATP1A1A.2; cka1; LIMK1; FIGN
Function cyclin binding
Related Protein CDK2; CUL3; CDK14; CDK12; INCA1; CDK4; CDKN1A; CDK13; PTCH1; CDK5RAP3
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein CDK19; MAK; CDK9; CDKL3; MOK; CDKL5; CDK8; CDK1; CDKL1; CDKL2
Function protein binding
Related Protein SYNPO2L; HMBOX1; MCC; SPG21; PTPN13; MEGF6; CECR2; EIF3C; EEF2; AHNAK

Interacting Protein

CDK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK6.
CDKN2A; CCND3

CDK6 Related Articles

Caro-Astorga, J; Fajardo, I; et al. Nascent histamine induces alpha-synuclein and caspase-3 on human cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 451:580-586(2014).
Xu, F; Liu, J; et al. LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses. CANCER RESEARCH 74:3418-3428(2014).