cdk9
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  • Official Full Name
  • cyclin-dependent kinase 9
  • Background
  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CDK9; cyclin-dependent kinase 9; TAK; C-2k; CTK1; CDC2L4; PITALRE; CDC2-related kinase; cell division protein kinase 9; serine/threonine protein kinase PITALRE; cell division cycle 2-like protein kinase 4; tat-associated kinase complex catalytic subunit;
Cat.#:CDK9-1040HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDK9 Protein, GST-Tagged
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Cat.#:CDK9-1042HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CDK9 Protein, His-Tagged
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Cat.#:CDK9-2705HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK9 protein, His & T7-tagged
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Cat.#:CDK9-27909THTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human CDK9 Unactive protein, GST-tagged
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Cat.#:CDK9-280HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Cyclin-Dependent Kinase 9, GST-tagged, Active
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Cat.#:CDK9-1309RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDK9 Protein
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Cat.#:CDK9-791RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDK9 Protein, His-tagged
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Cat.#:CDK9-1350CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDK9
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Cat.#:CDK9-11870ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDK9
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Cat.#:CDK9-178HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDK9 lysate
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Involved Pathway

CDK9 involved in several pathways and played different roles in them. We selected most pathways CDK9 participated on our site, such as Disease, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK9 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Disease
PPIA; TNKS2; GYG2; IPO5; AP1B1; GPC5; RBP4; PACS1; NUP50; FMOD
Formation of HIV elongation complex in the absence of HIV Tat
ELL; PSTPIP2; CTDP1; TH1L; SUPT5H; WHSC2; TCEB3; RDBP; CDK9; COBRA1
Formation of HIV-1 elongation complex containing HIV-1 Tat
RDBP; SUPT5H; TCEB3; SUPT4H1; ELL; COBRA1; SSRP1; CTDP1; WHSC2; TH1L
Formation of RNA Pol II elongation complex
SSRP1A; SUPT5H; SUPT4H1; COBRA1; CTDP1; CDK9; WHSC2; CCNT2B; PSTPIP2; SUPT16H
Gene Expression
ZNF624; ZNF41; ZNF302; NR1D2B; DDX6; ZNF224; SUZ12B; ZNF221; ZNF100; NR5A1
Generic Transcription Pathway
NR4A2B; ZNF500; ZNF670; GPR19; NR1D2B; ZNF664; COX18; NR6A1A; ZNF550; ZNF43
HIV Infection
NPM1; PSTPIP2; RCC1; DOCK2; APOBEC3G; TAF1L; CHMP4B; AP1S1; NMT2; CDK9
HIV Life Cycle
CHMP4B; NMT2; NMT1; RCC1; SSRP1; PSIP1; PDCD6IP; VPS37A; CDK9; ELL

Protein Function

CDK9 has several biochemical functions, for example, ATP binding, DNA binding, RNA polymerase II carboxy-terminal domain kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK9 itself. We selected most functions CDK9 had, and list some proteins which have the same functions with CDK9. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein HSC70; CARS; MAP4K3; PHKG1A; CLP1; MERTK; THRAP3; PAK1; EPHA1; EGFR
Function DNA binding
Related Protein ZNF83; ZNF580; KIF4A; IMPDH2; HOXA3A; IRX5B; ZHX3; EBF3A; SPRTN; JUN
Function RNA polymerase II carboxy-terminal domain kinase activity
Related Protein CDK1; CDK13; CDK7; CCNK; CDK9; MAPK1; CDK8; CDK12
Function chromatin binding
Related Protein NR5A1; OST4; PCGF2; CEBPB; CENPA; KLF6A; ORC1L; BAZ1B; SIRT7; HHEX
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein PFTK1; CDK20; CDK8; ICK; CDK17; CCNK; CDK4; CDKL2; CDK11A; CDK10
Function protein binding
Related Protein ILK; SEC22A; MAP3K4; SCYL1; RUNX1T1; FBXO32; MT1A; SRMS; TLX1; TEAD1
Function protein kinase activity
Related Protein RPS6KAL; CAMK2B1; HIPK3B; FGFR1A; CCL8; RPS6KA3B; MAP3K14; CDKL3; STK35L; EIF2AK2
Function snRNA binding
Related Protein SNRNP35; CCNT1; NCBP2; HEXIM2; CDK9; HEXIM1; RBPMS
Function transcription factor binding
Related Protein RB1; NFATC2; HES6; PDX1; CDK9; NEUROD1; AHR; KDM1A; PBX2; HMGA2
Function transcription regulatory region DNA binding
Related Protein ASH2L; DDIT3; TBL1XR1; SERPINB1A; MTERF3; MSX2; CDK5RAP2; BCL11B; NKX2-5; FOXA1

Interacting Protein

CDK9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK9.
CCNT1; AFF1

CDK9 Related Articles

Holcakova, J; Muller, P; et al. Inhibition of Post-Transcriptional RNA Processing by CDK Inhibitors and Its Implication in Anti-Viral Therapy. PLOS ONE 9:-(2014).
Mbonye, UR; Gokulrangan, G; et al. Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4(+) T Lymphocytes. PLOS PATHOGENS 9:-(2013).