cdk9
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  • Official Full Name
  • cyclin-dependent kinase 9
  • Background
  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CDK9; cyclin-dependent kinase 9; TAK; C-2k; CTK1; CDC2L4; PITALRE; CDC2-related kinase; cell division protein kinase 9; serine/threonine protein kinase PITALRE; cell division cycle 2-like protein kinase 4; tat-associated kinase complex catalytic subunit;
Cat.#:CDK9-1040HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDK9 Protein, GST-Tagged
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Cat.#:CDK9-1042HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CDK9 Protein, His-Tagged
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Cat.#:CDK9-2705HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK9 protein, His & T7-tagged
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Cat.#:CDK9-27909THTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human CDK9 Unactive protein, GST-tagged
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Cat.#:CDK9-280HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Cyclin-Dependent Kinase 9, GST-tagged, Active
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Cat.#:CDK9-1309RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDK9 Protein
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Cat.#:CDK9-791RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDK9 Protein, His-tagged
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Cat.#:CDK9-1350CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDK9
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Cat.#:CDK9-11870ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDK9
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Cat.#:CDK9-178HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDK9 lysate
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Involved Pathway

CDK9 involved in several pathways and played different roles in them. We selected most pathways CDK9 participated on our site, such as Disease, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK9 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Disease
SFTPB; gag; NMT1; PPIA; OPN1LW; PRELP; AP1G1; AP2B1; CCDC167; NMT2
Formation of HIV elongation complex in the absence of HIV Tat
SUPT5H; WHSC2; TCEA1; SSRP1; CTDP1; PSTPIP2; ELL; SUPT4H1; RDBP; TCEB3
Formation of HIV-1 elongation complex containing HIV-1 Tat
RDBP; CDK9; WHSC2; ELL; SUPT4H1; COBRA1; TCEB3; TH1L; TCEA1; SSRP1
Formation of RNA Pol II elongation complex
RDBP; TCEA1; GM3258; SUPT4H1; TCEB3; SUPT5H; CCNT2A; COBRA1; SSRP1A; CCNT2B
Gene Expression
UBTF; WDR4; FAM36A; ZNF398; GM3258; ZNF74; RXRBB; ZNF212; IGF2BP2; ALKBH8
Generic Transcription Pathway
RARAA; ZNF484; ZNF92; YAP1; NR5A1A; ZNF180; ESRRGA; ZNF3; ZNF691; ZNF213
HIV Infection
APOBEC3G; NMT1; AP1S1; SSRP1; PPIAL4A; TAF1L; PACS1; CHMP4C; RCC1; PDCD6IP
HIV Life Cycle
TCEB3; VPS37A; CHMP4C; CHMP4B; NMT2; TAF1L; ELL; NMT1; PSIP1; RCC1

Protein Function

CDK9 has several biochemical functions, for example, ATP binding, DNA binding, RNA polymerase II carboxy-terminal domain kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK9 itself. We selected most functions CDK9 had, and list some proteins which have the same functions with CDK9. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CDC6; TYK2; CDK4; PASK; OXSR1A; ATP2A1L; HSPE1; STK31; DDX47; BBS10
Function DNA binding
Related Protein PHC1; ZNF784; ZNF705B; PAX7A; HIST1H4B; RAD54L; ZFP287; CTCFL; MXD4; POU6F2
Function RNA polymerase II carboxy-terminal domain kinase activity
Related Protein CDK12; CDK13; CDK1; CDK9; CDK7; MAPK1; CDK8; CCNK
Function chromatin binding
Related Protein GLI3; SMARCE1; NR5A1B; PBRM1; NFIA; PARP1; SLC30A9; HMGB2B; PRMT6; MORF4L1
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein CDK12; CDK5; CDK11B; MOK; CDK15; MAK; CDK1; PFTK1; CCNK; CDK9
Function protein binding
Related Protein DRAM1; ABCF3; KRT18; BCL2L2; ENPP1; FOXC2; DHX58; RAD9B; NFASC; ERG
Function protein kinase activity
Related Protein ERBB4A; NEK4; ADRBK2; LMTK2; MAP3K11; PTK2AA; PRKCG; STK24B; IRAK4; SGK2A
Function snRNA binding
Related Protein HEXIM2; RBPMS; NCBP2; SNRNP35; HEXIM1; CDK9; CCNT1
Function transcription factor binding
Related Protein NFIA; TFDP1B; MYC; RBPJ; TNFRSF10A; HES2; CDKN2A; HDAC9; NFKB1; SMAD3
Function transcription regulatory region DNA binding
Related Protein HNF1A; ATF4; GATA4; RBBP5; BCL11AA; TAF2; REST; GABPA; NKX3-1; NKX2-1

Interacting Protein

CDK9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK9.
CCNT1; AFF1

CDK9 Related Articles

Holcakova, J; Muller, P; et al. Inhibition of Post-Transcriptional RNA Processing by CDK Inhibitors and Its Implication in Anti-Viral Therapy. PLOS ONE 9:-(2014).
Mbonye, UR; Gokulrangan, G; et al. Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4(+) T Lymphocytes. PLOS PATHOGENS 9:-(2013).