CDKN1A Protein, cyclin-dependent kinase inhibitor 1A (p21, Cip1)


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Official Full Name cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Background This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]
Synonyms CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; cyclin-dependent kinase inhibitor 1; DNA synthesis inhibitor; CDK-interacting protein 1; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Mouse
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cdkn1a-869M Recombinant Mouse Cdkn1a Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CAB-2544MH Mouse Anti-Human p21/WAF1 Monoclonal Antibody Mouse N/A
    Human CDKN1A-1053H Recombinant Human CDKN1A Protein, GST-Tagged Wheat Germ GST
    Human CDKN1A-116H Recombinant Human CDKN1A Protein, His-tagged E.coli His
    Human CDKN1A-169H Recombinant Human Cyclin-dependent Kinase Inhibitor 1A (p21, Cip1) E.coli N/A
    Human CDKN1A-30053TH Recombinant Human CDKN1A E.coli N/A
    Human CDKN1A-311H Recombinant Human CDKN1A protein, His/MBP-tagged E.coli His/MBP
    Human CDKN1A-312H Recombinant Human CDKN1A protein, His/MBP-tagged E.coli His/MBP
    Human CDKN1A-4837H Recombinant Human Cyclin-Dependent Kinase Inhibitor 1A, GST-tagged E.coli GST
    Human CDKN1A-7157H Recombinant Human Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1), His-tagged E.coli His
    Human CDKN1A-7158H Recombinant Human CDKN1A, His-tagged E.coli His
    Human CDKN1A-7618HCL Recombinant Human CDKN1A 293 Cell Lysate HEK293 N/A
    Mouse Cdkn1a-1774M Recombinant Mouse Cdkn1a protein, His-tagged E.coli His
    Mouse CDKN1A-3220M Recombinant Mouse CDKN1A Protein Mammalian Cell His
    Rat Cdkn1a-1251R Recombinant Rat Cdkn1a protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque CDKN1A-793R Recombinant Rhesus monkey CDKN1A Protein, His-tagged Mammalian Cell His
    Chicken CDKN1A-5966C Recombinant Chicken CDKN1A Mammalian Cell His
    Zebrafish CDKN1A-6910Z Recombinant Zebrafish CDKN1A Mammalian Cell His

    CDKN1A involved in several pathways and played different roles in them. We selected most pathways CDKN1A participated on our site, such as AKT phosphorylates targets in the cytosol, AMPK signaling, Adaptive Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AKT phosphorylates targets in the cytosol CHUK; CDKN1A; CDKN1B; AKT3
    Adaptive Immune System LILRB1; PDPK1A; FRS2B; CLEC2B; CTSO; CD200R1; KIF3C; KIF2B; EGF; AP1S1
    Adipogenesis HMGA1-RS1; CELF1; PIANP; AHR; NAMPT; FOXC2; BMP1; NR2F1A; BSCL2; SMAD3B
    AhR pathway CYP1A2; JUND; NQO1; CDKN1A; EGFR; FLG; CYP1A1; AIP; CYP1B1; PTGES3
    Alpha6-Beta4 Integrin Signaling Pathway EIF4EB; CD151; CD151L; EGFR; SMAD3B; NTN1A; EIF4EBP1; CDKN1A; DST; EIF4E
    Androgen receptor signaling pathway TGFB1I1; EGFR; DAXX; SVILA; HTATIP; NR2C2; SMARCE1; MYST2; JUN; ETV5A
    Angiopoietin receptor Tie2-mediated signaling CRK; BMX; ELF2; AGTR1; DOK2; GRB14; GRB7; CDKN1A; ELF1

    CDKN1A has several biochemical functions, for example, cyclin binding, cyclin-dependent protein kinase activating kinase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN1A itself. We selected most functions CDKN1A had, and list some proteins which have the same functions with CDKN1A. You can find most of the proteins on our site.

    Function Related Protein
    cyclin binding INCA1; PFTK1; FBXW7; CDK14; CDK2; CDK5RAP3; CDK4; CDKN1A; HDAC3; USP2
    cyclin-dependent protein kinase activating kinase activity ALPK2; CDKN1A
    cyclin-dependent protein serine/threonine kinase inhibitor activity HEXIM2; CDKN1C; HEXIM1; CDKN1A; Casp3; CDKN2D; CDKN2C; CDKN1BA; KAT2B; CDKN1BB
    metal ion binding ZNF317; TRPM6; KDM5D; ZNF333; MCEE; CNOT7; NR2F6B; ZIC5; PARN; PRKCE
    protein binding PPP2R5C; NME7; CDC73; STX10; ACTR3; ACTR8; DPH2; PIDD1; ZSCAN12; PNKD
    protein complex binding MYC; SIX2; PTCH1; ABI1; EP300; PAFAH1B1; TAB1; MLKL; CRIPT; HADHA
    ubiquitin protein ligase binding RB1; TRIM37; UBE2H; TPI1; TRAF2; YWHAE; USP25; UBE2N; CUL2; AXIN1

    CDKN1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN1A.

    CDK2; PCNA

    Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
    Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).

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