CDKN1C Protein, cyclin-dependent kinase inhibitor 1C (p57, Kip2)


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Official Full Name cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Background This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
Synonyms CDKN1C; cyclin-dependent kinase inhibitor 1C (p57, Kip2); BWS; WBS; p57; BWCR; KIP2; cyclin-dependent kinase inhibitor 1C; p57Kip2; cyclin-dependent kinase inhibitor p57; P57; OTTHUMP- 00000011736; OTTHUMP00000011738; Beckwith- Wiedemann syndrome; OTTHUMP00000229152
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDKN1C-1059H Recombinant Human CDKN1C Protein, GST-Tagged Wheat Germ GST
    Human CDKN1C-11061H Recombinant Human CDKN1C, His-tagged E.coli His
    Human CDKN1C-30575TH Recombinant Human CDKN1C Wheat Germ N/A
    Mouse CDKN1C-3222M Recombinant Mouse CDKN1C Protein Mammalian Cell His
    Zebrafish CDKN1C-275Z Recombinant Zebrafish CDKN1C Mammalian Cell His

    CDKN1C involved in several pathways and played different roles in them. We selected most pathways CDKN1C participated on our site, such as Cell cycle, Endochondral Ossification, G1 to S cell cycle control, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle UIMC1; GORASP1; TERF2; TUBB4A; MIS18BP1; CDC25C; HDAC1; SPDL1; RNF168; MCM3L
    Endochondral Ossification COL10A1A; PTH; ADAMTS1; SOX6; SOX5; KIF3A; RUNX2A; FRZB; PTHLH; ADAMTS5
    G1 to S cell cycle control MYT1; ATF6B; TFDP1B; E2F6; CDKN1C

    CDKN1C has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN1C itself. We selected most functions CDKN1C had, and list some proteins which have the same functions with CDKN1C. You can find most of the proteins on our site.

    Function Related Protein
    cyclin-dependent protein serine/threonine kinase inhibitor activity CDKN1B; INCA1; Casp3; CDKN1A; CDKN2A; CDKN1BB; KAT2B; CDKN1C; CDKN2C; HEXIM1
    protein binding ERP44; ADAR; FDXR; NFKBIA; GCNT1; PHF8; MX2; CKS1B; KLRC4-KLRK1; PLSCR1

    CDKN1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN1C here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN1C.

    CDK2; MCM7; FBXL12; Cdk1; CDK4; PCNA; CCNE2

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